Category: 100-54-9

Guo, Leilei;Yang, Wenlong;Cheng, Xi;Fan, Zhixia;Chen, Ximeng;Ge, Feng;Dai, Yijun published 《Degradation of neonicotinoid insecticide acetamiprid by two different nitrile hydratases of Pseudaminobacter salicylatoxidans CGMCC 1.17248》. The research results were published in《International Biodeterioration & Biodegradation》 in 2021.Quality Control of 3-Cyanopyridine The article conveys some information:

Acetamiprid is a neonicotinoid insecticide used worldwide that has caused environmental pollution and adverse effects on ecosystems. Here, a novel bacterium, Pseudaminobacter salicylatoxidans CGMCC 1.17248, was isolated to rapidly degrade acetamiprid to IM-1-2 via hydration. Gene cloning and overexpression demonstrated that two nitrile hydratases, AnhA and AnhB, converted acetamiprid to IM-1-2. Escherichia coli overexpressing AnhA and AnhB degraded 98.1% and 94.0% of acetamiprid (1.0 mmol L^-1) in 5 min and 8 h, resp. The pure AnhA and AnhB had a V_max value of 14.12 and 1.20 μmol mg^-1 min^-1, resp., and a Km value of 1.02 mmol L^-1 and 2.95 mmol L^-1, resp. Compared with AnhA, AnhB had broad pH stability, as well as metal ions and organic solvents tolerance. Expression of AnhA and AnhB was induced by decreasing the nutrient concentration of culture broth and addition of urea and therefore significantly enhanced acetamiprid degradation of CGMCC 1.17248. qPCR indicated that the expression of AnhA and AnhB under the cultured conditions of 1/15 lysogeny broth or 0.5% urea addition was improved by from 2.2 to 5.3 times. The results presented herein will facilitate development of bioremediation agents for acetamiprid pollution and understanding of the functional role of bacterial nitrile hydratase.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Quality Control of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rao, P. Purnachandra;Nowshuddin, Shaik;Jha, Anjali;Rao, B. Leela Maheswara;Divi, Murali K.;Rao, M. N. A. published 《Bis-morpholinophosphorylchloride, a novel reagent for the conversion of primary amides into nitriles》. The research results were published in《Tetrahedron Letters》 in 2021.COA of Formula: C6H4N2 The article conveys some information:

Bis-morpholinophosphorylchloride(Bmpc),in the presence of a base,was an efficient dehydrating agent for both aromaticand aliphatic primary amides, and gives corresponding nitriles under mild conditions in good yields and purity. During the reaction the enantiomeric integrity remains intact. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.COA of Formula: C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100-54-9In 2021, Zhuo, Liang;Xie, Shihua;Wang, Hui;Zhu, Hongjun published 《Aerobic Visible-Light Induced Intermolecular S-N Bond Construction: Synthesis of 1,2,4-Thiadiazoles from Thioamides under Photosensitizer-Free Conditions》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:

Aerobic visible-light induced intermol. S-N bond construction has been achieved without the addition of photosensitizer, metal, or base. With this strategy, 1,2,4-thiadiazoles I (R = Ph, 4-methoxyphenyl, thiophen-3-yl, etc.; R¹ = 4-methoxyphenyl, 2,6-dimethylphenyl, thiophen-2-yl, etc.) can be obtained from thioamides R/R¹C(S)NH₂. Preliminary mechanistic investigation suggested that the excited state of thioamides undergoes a single-electron-transfer (SET) process to afford thioamidyl radicals, which can be further transformed into a 1,2,4-thiadiazole through desulfurization and oxidative cyclization. The reaction has good functional group tolerance and represents a green method for the construction of S-N bonds.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Application of 100-54-9 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qiu, Shanguang;Chen, Yuxue;Song, Xinming;Liu, Li;Liu, Xi;Wu, Luyong published 《Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles》. The research results were published in《Synlett》 in 2021.Electric Literature of C6H4N2 The article conveys some information:

Intermol. cycloaddition of tosylhydrazones with nitriles was investigated. T-BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H-1,2,3-triazoles I [R¹ = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.; R² = Ph, 3-BrC₆H₄, 2-thienyl, etc.] were prepared in good to excellent yields and with high purities. The process was azide-free and transition-metal-free.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Electric Literature of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xuan;Nottingham, Kyle G.;Patel, Chirag;Alegre-Requena, Juan V.;Levy, Jeffrey N.;Paton, Robert S.;McNally, Andrew published 《Phosphorus-mediated sp²-sp³ couplings for C-H fluoroalkylation of azines》. The research results were published in《Nature (London, United Kingdom)》 in 2021.Category: pyridine-derivatives The article conveys some information:

Fluoroalkyl groups profoundly affect the phys. properties of pharmaceuticals and influence almost all metrics associated with their pharmacokinetic and pharmacodynamic profile. Drug candidates increasingly contain trifluoromethyl (CF₃) and difluoromethyl (CF₂H) groups, and the same trend in agrochem. development shows that the effect of fluoroalkylation translates across human, insect and plant life. New fluoroalkylation reactions have undoubtedly stimulated this shift; however, methods that directly convert C-H bonds into C-CF₂X groups (where X is F or H) in complex drug-like mols. are rare. Pyridines are the most common aromatic heterocycles in pharmaceuticals, but only one approach – via fluoroalkyl radicals – is viable for achieving pyridyl C-H fluoroalkylation in the elaborate structures encountered during drug development. Here we develop a set of bench-stable fluoroalkylphosphines that directly convert the C-H bonds in pyridine building blocks, drug-like fragments and pharmaceuticals into fluoroalkyl derivatives No preinstalled functional groups or directing groups are required. The reaction tolerates a variety of sterically and electronically distinct pyridines, and is exclusively selective for the 4-position in most cases. The reaction proceeds through initial formation of phosphonium salts followed by sp²-sp³ coupling of phosphorus ligands – an underdeveloped manifold for forming C-C bonds. Thus, e.g., treatment of 2-phenylpyridine with (fluoroalkyl)phosphine I, Tf₂O and DBU afforded intermediate phosphonium salt (not isolated) which, upon treatment with TfOH, MeOH and water afforded II (89%). And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4N2《Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines》 was published in 2021. The authors were Chen, Yan;Shatskiy, Andrey;Liu, Jian-Quan;Karkas, Markus D.;Wang, Xiang-Shan, and the article was included in《Organic Letters》. The author mentioned the following in the article:

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates CNCH₂C(O)₂R (R = Me, Et) with pyridinium salts, e.g., 2-(2-oxo-2-phenylethyl)-isoquinolinium bromide is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds, e.g., I. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 100-54-9In 2021, Yuan, Feixiang;Xie, Shihua;Zhuo, Liang;Wang, Lei;Zhu, Hongjun published 《Metal-Free Synthesis of 2-Aryl Quinazolines via Tandem C-H/N-H Bond Functionalization》. 《ChemistrySelect》published the findings. The article contains the following contents:

The present work provides a facile and highly efficient strategy (ca. ∼92%) for the synthesis of quinazoline compounds e.g., I, which involves tandem C-H/N-H bond functionalization using metal-free conditions without the need for an external oxidant. Meanwhile, the reaction system exhibits good functional group tolerance and a wide substrate scope. Furthermore, corresponding isotope tracking experiments have shown that DMSO acts as a carbon source. Finally, this work affords a new strategy toward the further design and synthesis of heteroaromatic rings.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.SDS of cas: 100-54-9 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 3-Cyanopyridine《Recyclable and Reusable Pd(OAc)₂/XPhos-SO₃Na/PEG-400/H₂O System for Cyanation of Aryl Chlorides with Potassium Ferrocyanide》 was published in 2022. The authors were Cai, Mingzhong;Liu, Rong;Xu, Caifeng;Huang, Bin, and the article was included in《Catalysis Letters》. The author mentioned the following in the article:

Pd(OAc)₂/XPhos-SO₃Na in a mixture of poly(ethylene glycol) (PEG-400) and water is shown to be a highly efficient catalyst for the cyanation of aryl chlorides with potassium ferrocyanide. The reaction proceeded smoothly at 100 or 120°C with K₂CO₃ or KOAc as base, delivering a variety of aromatic nitriles in good to excellent yields. The isolation of the crude products is facilely performed by extraction with cyclohexane and more importantly, both expensive Pd(OAc)₂ and XPhos-SO₃Na in PEG-400/H₂O system could be easily recycled and reused at least six times without any apparent loss of catalytic efficiency. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Reference of 3-Cyanopyridine This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4N2《Blue LED induced solvent-free multicomponent reactions among aryl diazoacetates, pyridine derivatives and maleimides: direct eco-friendly synthesis of densely functionalized itaconimides》 was published in 2022. The authors were Maiti, Debajit;Das, Ranajit;Prabakar, Tejas;Sen, Subhabrata, and the article was included in《Green Chemistry》. The author mentioned the following in the article:

Herein a hitherto novel multicomponent reaction involving pyridine and its derivatives I (R¹ = H, 4-Me, 4-CN) aryl diazoesters ArC(=N₂)C(O)OR² (Ar = Ph, thiophen-3-yl, 4-bromophenyl, etc.; R² = Me, Et) and N-methyl/ethylmaleimide (2 equiv), using a blue LED under neat (solvent-free) conditions and in the absence of any metal catalysts or bases at r. t. to generate densely substituted itaconimides was reported. This environmentally sustainable strategy generated the desired products II (R³ = Me, Et) in excellent yields. The reaction involved the carbene formation of aryl diazoesters from a blue LED and a subsequent generation of pyridine ylides. The pyridine ylides underwent [3 + 2] cycloaddition with N-alkyl maleimides followed by oxidation, subsequent ring opening of the [3 + 2] adducts and finally reaction with another mol. of N-alkyl maleimides to afford the desired itaconimide derivatives The reaction has wide functional group tolerance at the aryl moiety of the diazoesters and also on pyridine. Control experiments and DFT studies were used to elucidate the reaction mechanism. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Yanggao;Zhu, Limeng;He, Kang;Yang, Ze;Ma, Sicai;Lei, Jiaheng published 《Synthesis of three imidazole derivatives and corrosion inhibition performance for copper》. The research results were published in《Journal of Molecular Liquids》 in 2022.Synthetic Route of C6H4N2 The article conveys some information:

Three imidazole derivatives I [X = 3-pyridyl, 2-pyrazinyl, 2-pyrimidinyl], were synthesized. The structure of these compounds was confirmed by LC-MS, ¹H NMR, ¹³C NMR and FTIR spectra. The inhibition performance in 3.5 wt% NaCl was investigated by electrochem. measurement and surface anal. Results showed that the corrosion efficiency of I [X = 3-pyridyl] (95.93%) was higher than I [X = 2-pyrazinyl] (69.61%) and I [X = 2-pyrimidinyl] (20.46%), which was consistent with the adsorption energy calculated by mol. dynamics simulation. The corrosion inhibition mechanism could be explained by the metal-organic polymer film formed on the copper surface: on the one hand, the π-system formed by aromatic rings is tightly adsorbed on the copper substrates; on the other hand, the nitrogen atoms in the imidazole ring are coordinated with the metal ions in solution to form metal-organic polymer which could improve the compactness of the hydrophobic film.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem