Category: 100-54-9

Today I want to share an article with you. The article is 《Transition-Metal-Free Regioselective Direct C2, C4 Difunctionalization and C2, C4, C6 Trifunctionalization of Pyridines》,you can find this article in 《Advanced Synthesis & Catalysis》. The following contents are mentioned:

This study reports the invention of di- or trifunctionalization of readily available pyridines (including all the pyridine substrates utilized in this paper, such as 3-cyanopyridine and 3-chloropyridine) through dearomative functionalization-oxidative rearomatization under transition-metal- and reductant-free conditions. Although a two-step operation is required, the crude product of the first step could be used in the next step directly. Typically, 3-π-EWG pyridines underwent difunctionalization, whereas 3-σ-EWG pyridines participate in trifunctionalization, affording multisubstituted piperidines. Computational studies provide detailed insights for their distinct reactivity in the title reaction. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 3-Cyanopyridine《High-throughput screening of a nicotinate dehydrogenase producing Pseudomonas putida mutant for efficient biosynthesis of 6-hydroxynicotinic acid》 was published in 2021. The authors were Shang, Yu-Ting;Qin, Jiufu;Gong, Jin-Song;Wang, Zi-Kai;Li, Heng;Li, Hui;Shi, Jin-Song;Xu, Zheng-Hong, and the article was included in《Molecular Catalysis》. The author mentioned the following in the article:

A nicotinate dehydrogenase producing strain was isolated and identified to be Pseudomonas putida, which could bio-transform nicotinic acid into 6-hydroxynicotinic acid. The activity of nicotinate dehydrogenase towards nicotinic acid could reach up to 1.11 U/mL and the yield of 6-hydroxynicotinic acid accumulated to 176 g/L within 30 h with a space time yield of 1.36 g/(g·h). In order to further improve its catalytic potential, a mutant library was constructed through atm. and room temperature plasma (ARTP) and rapidly screened by a high-throughput screening strategy, which obtained a mutant strain mut-5 with activity of 2.68 U/mL. Via developing a nitrilase-nicotinate dehydrogenase enzymic cascade system, 54.5 g/L 6-hydroxynicotinic acid could be obtained within 585 min with 3-cyanopyridine as the substrate, which would further reduce the production costs. The results indicated that the nicotinate dehydrogenase (sep. or combining with nitrilase) could serve as a superior catalyst for 6-hydroxynicotinic acid production To our knowledge, the nicotinate dehydrogenase activity reported in this study was the highest level in literature to date. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Safety of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 100-54-9《A pharmaceutical-related molecules dataset for reversed-phase chromatography retention time prediction built on combining pH and gradient time conditions》 was published in 2022. The authors were Van Laethem, Thomas;Kumari, Priyanka;Hubert, Philippe;Fillet, Marianne;Sacre, Pierre-Yves;Hubert, Cedric, and the article was included in《Data in Brief》. The author mentioned the following in the article:

There is a rising interest in the modeling and predicting of chromatog. retention. The progress towards more complex and comprehensive models emphasized the need for broad reliable datasets. The present dataset comprises small pharmaceutical compounds selected to cover a wide range in terms of physicochem. properties that are known to impact the retention in reversed-phase liquid chromatog. Moreover, this dataset was analyzed at five pH with two gradient slopes. It provides a reliable dataset with a diversity of conditions and compounds to support the building of new models. To enhance the robustness of the dataset, the compounds were injected individually, and each sequence of injections included a quality control sample. This unambiguous detection of each compound as well as a systematic anal. of a quality control sample ensured the quality of the reported retention times. Moreover, three different liquid chromatog. systems were used to increase the robustness of the dataset. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Product Details of 100-54-9 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 3-Cyanopyridine《Palladium-catalyzed synthesis of nitriles from N-phthaloyl hydrazones》 was published in 2022. The authors were Ano, Yusuke;Higashino, Masaya;Yamada, Yuki;Chatani, Naoto, and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:

The Pd-catalyzed transformation of N-phthaloyl hydrazones into nitriles RC≡N [R = 3-pyridyl, 4-MeC₆H₄, 2-naphthyl, etc.] and R(Me)C=CHC≡N involving the cleavage of an N-N bond was reported. The use of N-heterocyclic carbene as a ligand was essential for the success of the reaction. N-Phthaloyl hydrazones prepared from aromatic aldehydes or cyclobutanones were applicable to this transformation, which gaves aryl nitriles RC≡N or alkenyl nitriles R(Me)C=CHC≡N, resp.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Safety of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Feng, Xiaoxia;Li, Dong;Liang, Wenqing;Ruan, Ting;Jiang, Guibin published 《Recognition and prioritization of chemical mixtures and transformation products in Chinese estuarine waters by suspect screening analysis》 in 2021. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Recommanded Product: 3-Cyanopyridine The article mentions the following:

Chem. mixtures in surface waters could have significant impacts on exposure risks to human beings and pollution stress to aquatic system. By suspect screening anal. of high-resolution mass spectrometry data, occurrence, and compositions of ToxCast chems. were investigated in grab estuarine water samples from a combination of 20 rivers that represents approx. 70% of the total river flow discharge along the east coast of China. In total, 59 ToxCast chems. in seven use categories were identified, in which pesticides, intermediates, and pharmaceuticals were the abundant analogs. Significant differences in pollutant composition profiles were noticed, which possibly reflected singular release pattern and geog.-relevant usage preference (especially for herbicides and fungicides in the pesticide category). With the aid of tentative quant./semiquant. measurement, essential contributors to the cumulative pollutant mass discharges and aquatic acute toxicity potentials were focused onto few particular chems. Existence of transformation products was further explored, which indicated that the fates of the selected parent ToxCast chems. could be influenced by dominating transformation reactions (e.g., N-dealkylation and hydroxylation) and possible environmental factors (i.e., microbial activity). The results emphasize the necessity of suspect screening anal. for assessing the influence of terrestrial emissions of pollutants to the surrounding environment. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Recommanded Product: 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Hyeongsu;Xuan, Zi;Hyun Kim, Ju published 《Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles》 in 2021. The article was appeared in 《Chemistry – An Asian Journal》. They have made some progress in their research.Formula: C6H4N2 The article mentions the following:

An efficient tandem route to obtain tetrasubstituted NH pyrroles I (R = Me, Et, Bn; Ar = Ph, 2-naphthyl, pyridin-3-yl, etc.) in a one-pot manner has been developed, staring from simple nitriles ArCN, Et bromoacetates BrCH₂CO₂R, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles I in yields up to 91%. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gogoi, Monsumi;Das, Birinchi Kumar published 《Tetraaquabis(pyridine-3-carbonitrile-κN¹)nickel(II) benzene-1,4-dicarboxylate tetrahydrate》. The research results were published in《Acta Crystallographica, Section E: Crystallographic Communications》 in 2021.Synthetic Route of C6H4N2 The article conveys some information:

A nickel(II) terephthalate complex, viz. [Ni(C₆H₄N₂)₂(H₂O)₄](O₂CC₆H₄CO₂)·4H₂O, has been synthesized and studied by single-crystal X-ray diffraction. It crystallizes in the triclinic space group P [inline formula omitted] . The crystal structure shows an approx. octahedral coordination environment of the complex with the [Ni(H₂O)₄(3-NCpy)₂]²⁺ (3-NCpy is pyridine-3-carbonitrile) cation associated with four free water mols. and hydrogen bonded to a terephthalate dianion [graph set R22(8)]. The supramol. structure of the compound is stabilized by a three-dimensional array of O-H···O and O-H···N hydrogen bonds, along with π-π stacked pyridine-3-carbonitrile rings and C-H···O interactions. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H4N2In 2021, Kiani, Pirouz;Dodsworth, Elaine S.;Lever, A. B. P.;Pietro, William J. published 《Modeling ligand electrochemical parameters by repulsion-corrected eigenvalues》. 《Journal of Computational Chemistry》published the findings. The article contains the following contents:

Ligand electrochem. parameters, E_L, more commonly known as Lever parameters, have played a major research role in understanding redox processes involved in inorganic electrochem., enzymic reactions, catalysis, solar cells, biochem., and materials science. Despite their broad usefulness, Lever parameters are not well understood at a 1st-principles level. Using d. functional theory, the authors demonstrate in this contribution that a ligand′s Lever parameter is fundamentally related to the ligand′s ability to alter the eigenvalue of the electroactive spin-orbital in an octahedral transition metal complex. The authors′ anal. furthers a 1st-principles understanding of the nature of Lever parameters. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Synthetic Route of C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jia, Cong-Cong;Chen, Wang;Feng, Zi-Li;Liu, Zhao-Peng published 《Recent developments of RET protein kinase inhibitors with diverse scaffolds as hinge binders》. The research results were published in《Future Medicinal Chemistry》 in 2021.COA of Formula: C6H4N2 The article conveys some information:

A review. RET is a proto-oncogene encoding a receptor tyrosine kinase. RET regulates key aspects of cellular proliferation, differentiation and survival. The activation of RET via gene fusions or point mutations is closely related to lung, thyroid and other cancers. This review summarizes the developments of a diversity of small mol. RET protein kinase inhibitors in the past 10 years. These RET inhibitors are classified according to their hinge binder chemotypes as: pyrimidines, including the pyrazolopyrimidines, pyrimidine oxazines, quinazolines, 4-aminopyrimidines and 4-aminopyridines; indolinones; 5-aminopyrazole-4-carboxamides; 3-trifluoromethylanilines; imidazopyridines, imidazopyridazines and pyrazopyridines; nicotinonitriles; pyridones and 1,2,4-triazoles. In each section, the biol. activities of the inhibitors, their structure-activity relationships and possible binding modes with the RET kinase are introduced. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xia, Yu-Yan;Lv, Qing-Yang;Yuan, Hua;Wang, Jia-Yi published 《Selective oxidation of alcohols to nitriles with high-efficient Co-[Bmim]Br/C catalyst system》. The research results were published in《Chemical Papers》 in 2021.Category: pyridine-derivatives The article conveys some information:

An efficient method for catalyzing the ammoxidation of aromatic alcs. to aromatic nitriles was developed, in which a new heterogeneous catalyst based on transition metal elements was employed, the new catalyst was named Co-[Bmim]Br/C-700 and then characterized by X-ray photo-electronic spectroscopy, transmission electron microscope and X-ray diffraction. The reaction was carried out by two consecutive dehydrogenations under the catalysis of Co-[Bmim]Br/C-700, which catalytically oxidized the alc. to the aldehyde, and then the aldehyde was subjected to ammoxidation to the nitrile. The catalyst system was suitable for a wide range of substrates and nitriles obtained in high yields, especially, the conversion rate of benzyl alc., 4-methoxybenzyl alc., 4-chlorobenzyl alc. and 4-nitrobenzyl alc. reached 100%. The substitution of ammonia and oxygen for toxic cyanide to participate in the reaction accords with the theory of green chem. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem