Category: 100-54-9

Xue, Gaijun;Xie, Fukai;Liang, Hongliang;Chen, Guoliang;Dai, Wen published 《Copper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles》. The research results were published in《Organic Letters》 in 2022.Safety of 3-Cyanopyridine The article conveys some information:

The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, authors report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Safety of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H4N2In 2021, Rahman, Taskia;Borah, Geetika;Gogoi, Pradip K. published 《Activated Mont K10-Carbon supported Fe₂O₃: A versatile catalyst for hydration of nitriles to amides and reduction of nitro compounds to amines in aqueous media》. 《Journal of Chemical Sciences (Berlin, Germany)》published the findings. The article contains the following contents:

The iron oxide was successfully supported on activated clay/carbon through an exptl. viable protocol for both hydration of nitriles RCN (R = Ph, pyridin-4-yl, 4-bromophenyl, etc.) to RC(O)NH₂ to amides and reduction of nitro compounds R¹NO₂ (R¹ = Ph, 3-nitrophenyl, 2-trifluoromethyl-4-nitrophenyl, etc.) to amines R¹NH₂. The as-prepared catalyst has been extensively characterized by XPS, SEM-EDX, TEM, TGA, BET surface area measurements and powd. X-ray diffraction (PXRD). A wide variety of substrates could be converted to the desired products with good to excellent yields by using water as a green solvent for both the reactions. The catalyst was recyclable and reusable up to six consecutive cycles without compromising its catalytic proficiency. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morgan, Angela L.;Torpy, Fraser R.;Irga, Peter J.;Fleck, Robert;Gill, Raissa L.;Pettit, Thomas published 《The botanical biofiltration of volatile organic compounds and particulate matter derived from cigarette smoke》. The research results were published in《Chemosphere》 in 2022.COA of Formula: C6H4N2 The article conveys some information:

Despite the growing use of control measures, environmental tobacco smoke (ETS) remains a significant pollutant source in indoor air in many areas of the world. Current control methods for reducing ETS exposure are inadequate to protect public health in environments where cigarettes are smoked. An alternative solution is botanical biofiltration which has previously been shown to lower concentrations of volatile organic compounds (VOCs) and particulate matter (PM) from a range of polluted air streams. This study is the first to assess the potential of a botanical biofilter with the species Spathiphyllum wallisii (Peace Lily) for the removal of cigarette-derived VOCs and all size fractions of PM. Single pass removal efficiencies of 43.26% for total VOCs and 34.37% for total suspended particles were achieved. The botanical biofilter reduced the concentrations of a range of harmful ETS chems. including nicotine, limonene, and toluene. Evaluation of the re-emission of ETS constituents filtered by the botanical biofilter revealed no particle resuspension or off gassing. The results demonstrate the potential of botanical biofilters to reduce public ETS exposure, although further research is needed to improve upon and ensure the efficiency of these systems for practical applications. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.COA of Formula: C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4N2In 2022, Hethcox, J. Caleb;Sifri, Renee J. published 《Air-Tolerant Nickel-Catalyzed Cyanation of (Hetero)aryl Halides Enabled by Polymethylhydrosiloxane, a Green Reductant》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

An air-tolerant nickel-catalyzed cyanation of aryl bromides ArBr (Ar = 3,5-difluorophenyl, 2-naphthyl, pyridin-3-yl, etc.) is reported. The reaction uses a NiCl₂/Xantphos catalyst in combination with substoichiometric quantities of zinc cyanide and polymethylhydrosiloxane. This silane is a green, homogeneous alternative to the traditional, insoluble solid reductant zinc and renders the reaction tolerant to air. The reaction can be performed under an air atm., obviating the need for degassing, a glovebox, or Schlenk techniques. The reaction scope is broad, proceeding in good yields with a variety of (hetero)arenes. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.COA of Formula: C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nishida, Yoshihide;Sato, Katsutoshi;Chaudhari, Chandan;Yamada, Hiroshi;Toriyama, Takaaki;Yamamoto, Tomokazu;Matsumura, Syo;Aspera, Susan Menez;Nakanishi, Hiroshi;Haneda, Masaaki;Nagaoka, Katsutoshi published 《Nitrile hydrogenation to secondary amines under ambient conditions over palladium-platinum random alloy nanoparticles》 in 2022. The article was appeared in 《Catalysis Science & Technology》. They have made some progress in their research.Safety of 3-Cyanopyridine The article mentions the following:

Bimetalization between palladium (Pd) and platinum (Pt) nanoparticles, which resulted in a catalyst that showed high yield of secondary amines. Although Pd and Pt were thermodynamically immiscible, successfully alloyed the two metals by means of rapid chem. reduction assisted by microwave heating. X-ray absorption spectroscopy suggested the formation of heteroat. Pd^δ+Pt^δ- sites via charge transfer between neighboring Pd and Pt atoms in the alloy structure. Moreover, Fourier transform IR spectroscopy and scanning transmission electron microscopy-energy-dispersive X-ray spectroscopy indicated that decreasing the size of the PdPt (50 : 50) nanoparticles improved the degree of alloying and facilitated the formation of electron-enriched Pt^δ- species. On the basis of kinetics studies and d. functional theory calculations, that cyano group activation, which was the rate-determining step over monometallic Pd and Pt catalysts, was accelerated over the heteroat. Pd^δ+Pt^δ- sites because of strong back-donation from electron-enriched Pt^δ- species to the carbon atom of the cyano groups. The PdPt random alloy nanoparticles catalyzed the reactions of various aromatic and heterocyclic nitriles, and the corresponding secondary amines were selectively obtained in just a few hours. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Safety of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Verevkin, Sergey P.;Zherikova, Kseniya V.;Martynenko, Evgeniya A. published 《Molecular versus ionic liquids: Development of a thermodynamic framework for predicting vaporization thermodynamics》. The research results were published in《Journal of Molecular Liquids》 in 2022.Synthetic Route of C6H4N2 The article conveys some information:

Ionic liquids based on the pyridinium and quinolinium cations show good result in desulfurization of fuels. The knowledge of their vaporisation thermodn. is of practical importance. The standard molar enthalpies of vaporization of pyridinium based ionic liquids were derived from the vapor pressure temperature dependences measured by the quartz-crystal microbalance method. We have collected available primary exptl. results on vapor pressures, and enthalpies of phase transitions (solid-solid, crystal-gas, and liquid-gas) of analogus mol. species – substituted pyridines and quinolines. These data were evaluated using the structure-property correlations. The consistent sets of evaluated thermodn. data on the mol. and ionic liquids were used to develop the ′′centerpiece′′ based group-additivity method for predicting enthalpies of vaporization of mol. and ionic compounds The general transferability of the contributions to the enthalpy of vaporization from the mol. liquids to the ionic liquid has been established. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frejat, Firas Obaid Arhema;Cao, Yaquan;Zhai, Hongjin;Abdel-Aziz, Salah A.;Gomaa, Hesham A. M.;Youssif, Bahaa G. M.;Wu, Chunli published 《Novel 1,2,4-oxadiazole/pyrrolidine hybrids as DNA gyrase and topoisomerase IV inhibitors with potential antibacterial activity》. The research results were published in《Arabian Journal of Chemistry》 in 2022.Product Details of 100-54-9 The article conveys some information:

DNA gyrase is a promising target for antibacterial agents. Several classes of small-mol. inhibitors have been discovered in recent decades, but none of these have reached the market. We have designed a small library of 1,2,4-oxadiazole/pyrrolidine hybrids with mid nanomolar inhibitory and potent antibacterial activities against DNA gyrase and topoisomerase IV. Compounds 9, 15, 16, 19, and 21 inhibited Escherichia coli DNA gyrase to a similar extent as the reference compound, novobiocin, with inhibitory values ranging from 120 nM to 270 nM. Compound 16 was one of the most potent compounds in the series, with an IC50 value of 120 nM against E. coli gyrase, which is lower than the IC50 value of novobiocin (170 nM). Compound 16 had the highest inhibitory activity, with min. inhibitory concentrations (MIC) of 24 and 62 ng/mL against Staphylococcus aureus and E. coli, resp., which compared favorably with ciprofloxacin (30 and 60 ng/mL, resp.). Compounds 9, 15, 19, and 21 were similar to novobiocin in terms of their activity against E. coli and S. aureus topoisomerase IV, while compound 16 was more potent than novobiocin. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Product Details of 100-54-9 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Lihua;Tang, Juan;Sun, Rui;Li, Wenjing;Zheng, Xueli;Yuan, Maoling;Li, Ruixiang;Chen, Hua;Fu, Haiyan published 《Direct C-H Sulfonylimination of Pyridinium Salts》 in 2022. The article was appeared in 《Organic Letters》. They have made some progress in their research.Name: 3-Cyanopyridine The article mentions the following:

A direct pyridinium C-H sulfonylimination has been developed for the synthesis of sulfonyl iminopyridine derivatives I (R = H, CN, Ph, thiophen-2-yl, etc.; R¹ = H, OMe, Ph, thiophen-3-yl, etc.; R² = H, cyclopropyl, Ph, 4-bromophenyl, etc.; R¹R² = -CH=CH-CH=CH-; R³ = Me, Et, i-Pr, etc.; R⁴ = Et, Ph, pyridin-3-yl, etc.) with high efficiency. This transformation features the direct and efficient formation of a C=N bond with a high functional group tolerance under metal-free conditions. The spectroscopic properties potentially enable these sulfonyl iminopyridine compounds I to be useful new emitting materials. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Name: 3-Cyanopyridine This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Lifan;Song, Xuyan;Qi, Mei-Fang;Sun, Bing published 《Weak Bronsted base-promoted photoredox catalysis for C-H alkylation of heteroarenes mediated by triplet excited diaryl ketone》. The research results were published in《Tetrahedron Letters》 in 2022.Application of 100-54-9 The article conveys some information:

A weak Bronsted base-promoted photoredox catalysis had been developed for the direct C-H α-alkylation of heteroarenes with cyclic and acyclic ethers. The high efficiency of this strategy was demonstrated by the mild reaction conditions, broad substrate scope, economical reagents and high regioselectivity. With air as the sole oxidant, a set of alkylated heteroarenes were accessed smoothly. This strategy was also applied for late-stage functionalization of valuable vitamin E nicotinate and loratadine.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Application of 100-54-9 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 3-CyanopyridineIn 2021, Wang, Chang-Sheng;Sun, Qiao;Garcia, Felipe;Wang, Chen;Yoshikai, Naohiko published 《Cobalt-catalyzed intermolecular [2 + 2 + 2] cycloaddition of nitriles and alkynes: facile synthesis of polyarylpyridines and their mechanochemical cyclodehydrogenation to nitrogen-containing polyaromatics》. 《Angewandte Chemie, International Edition》published the findings. The article contains the following contents:

The transition-metal-catalyzed [2+2+2] cycloaddition of nitriles and alkynes is an established synthetic approach to pyridines; however, these cycloadditions often rely on the use of tethered diynes or cyanoalkynes as one of the reactants. Thus, examples of efficient, fully intermol. catalytic [2+2+2] pyridine synthesis, especially those employing unactivated nitriles and internal alkynes leading to pentasubstituted pyridines, remain scarce. Herein, we report on simple and inexpensive catalytic systems based on cobalt(II) iodide, 1,3-bis(diphenylphosphino)propane, and Zn that promote [2+2+2] cycloaddition of various nitriles and diarylacetylenes for the synthesis of a broad range of polyarylated pyridines. DFT studies support a reaction pathway involving oxidative coupling of two alkynes, insertion of the nitrile into a cobaltacyclopentadiene, and C-N reductive elimination. The resulting tetra- and pentaarylpyridines serve as precursors to hitherto unprecedented nitrogen-containing polycyclic aromatic hydrocarbons via mechanochem. assisted multifold reductive cyclodehydrogenation. Transition metal-catalyzed [2 + 2 + 2] cycloaddition of nitriles and alkynes has been extensively developed as a straightforward and atom-economical synthetic approach to pyridines over the last several decades using various transition metal catalysts, both precious and non-precious. Despite this long history, cycloadditions of this type have often relied on the use of tethered diyne or cyanoalkyne as one of the reactants. Thus, examples of efficient, fully intermol. catalytic [2 + 2 + 2] pyridine synthesis, especially those employing unactivated nitriles and internal alkynes leading to pentasubstituted pyridines, remain scarce. Herein, we report on simple and inexpensive catalytic systems based on cobalt(II) iodide, 1,3-bis(diphenylphosphino)propane, and Zn that promote [2 + 2 + 2] cycloaddition of various nitriles and diarylacetylenes without using a large excess of the nitrile. The present systems allow for the synthesis of broad range of polyarylated pyridines, many of which have not been previously accessed by the [2 + 2 + 2] manifold. Computational studies have supported a reaction pathway involving oxidative coupling of two alkynes, insertion of the nitrile into cobaltacyclopentadiene, and C-N reductive elimination, while shedding light on stepwise nature of the oxidative coupling and insertion processes. We also demonstrate that tetra- and pentaarylpyridines can serve as precursors to hitherto unprecedented nitrogen-containing polycyclic aromatic hydrocarbons via mechanochem. assisted multifold reductive cyclodehydrogenation. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem