Category: 100-55-0

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 100-55-0, Name is 3-Pyridinemethanol, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Tapdiqov, Shamo Zokhrab, Quality Control of 3-Pyridinemethanol.

Electrostatic and Hydrogen Bond Immobilization of Trypsine onto pH-Sensitive N-Vinylpyrrolidone and 4-Vinylpyridine Radical co-Grafted Chitosan Based on Hydrogel

The present investigation of new hydrogel based on chitosan was prepared by radical graft copolymerization of N-vinylpyrrolidone and 4-vinylpyridine with chitosan and cross-linking by N, N ‘-methylen-bis-acrylamide. The swelling behavior of the prepared hydrogel, with the optimal amount of gelator, was investigated. The hydrophilicity, and pH sensitivity of gel was suitable for trypsin carry. Trypsin was loaded onto the hydrogel enternal pores and surfaces by electrostatic interaction and hydrogen bond attachment. Several parameters, such as adsorbtion of pH value, loading time, and buffer solution concentration on trypsin loading amount, also enzyme activity were examined. According to the kinetic and FTIR, SEM spectroscopy analysis data trypsin was combination by the hydrogen bond and electrostatic interaction to the chitosan based structure. The hydrogen bonds were formed between -NH2, -CH2OH, >C=O, pyridine ring, -OH, and -NH- groups of carrier with -NH2, -COOH, -OH, >C=O, -NH-, disulfide bridge, ester groups of trypsine. In additional, at pH=5-8, the functional groups in the gel are partially ionized and take the form of -NH3+, -OH2+, >COH+. The protein is the same degree ionized in that medium, and the protein interacts electrostatically with the carrier.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 100-55-0, in my other articles. Quality Control of 3-Pyridinemethanol.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Radwan, Ahmed, once mentioned the application of 100-55-0, COA of Formula: C6H7NO, Name is 3-Pyridinemethanol, molecular formula is C6H7NO, molecular weight is 109.13, MDL number is MFCD00006407, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Anticancer and molecular docking studies of some new pyrazole-1-carbothioamide

Eight pyrazole-1-carbothioamide nucleosides were synthesized through conensation of 3-(4-aminophenyl)-pyrazole-1-carbothioamide derivative 2 with four aldoses (arabinose, mannose, glucose and galactose) and acetylation of the produced nucleosides 3a-d with acetic anhydride in pyridine at room temperature to give their corresponding acetyl derivatives 4a-d. Their chemical structures were confirmed by spectroscopic and elemental analysis. The antiproliferative activity was screened against various human cancer cell lines (MCF-7, HepG2 and HCT-116) in vitro; compound 4b showed a significant IC50 values (8.5 +/- 0.72 for MCF-7, 9.4 +/- 0.84 for HepG2 and 11.7 +/- 0.89 mu g/ml for HCT-116) which were close to the reference drug 5-fluorouracil (5-FU). Molecular docking study was utilized to illustrate the ability of the more active compounds 3b and 4b to inhibit thymidylate synthase and compare the results with an antimetabolite drug used in cancer chemotherapy Raltitrexed.

If you are interested in 100-55-0, you can contact me at any time and look forward to more communication. COA of Formula: C6H7NO.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

100-55-0, Adding a certain compound to certain chemical reactions, such as: 100-55-0, 3-Pyridinemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-55-0, blongs to pyridine-derivatives compound.

General procedure: In a 10 ml screw-capped vial was placed 2 mol% of manganese (I) catalyst, 1 equivalent of thebase, 0.1 ml of toluene , 0.2 mmol of alcohol and 0.4 mmol of amine under argon atmosphere. The reaction mixture was heated at 140C for 24 h in an oil bath. The reaction mixture was then cooledat ambient temperature, quenched with water and the organic layer was extracted with ethylacetate. The combined organic layers were dried over sodium sulfate and concentrated. 1H NMR yields were determined using 1,3,5-trimethoxy benzene as an internal standard. The product waspurified by silica gel column chromatography using the mixture of ethyl acetate and hexane aseluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-55-0, its application will become more common.

Reference:
Article; Das, Kuhali; Kumar, Amol; Jana, Akash; Maji, Biplab; Inorganica Chimica Acta; vol. 502; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem