Category: 100-70-9

Related Products of 100-70-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: a. Ground phosphoruspentasulfide (115 g, 0.5 mol) was added to asolution of 4-cyanopyridine (52 g, 0.5 mol) in 250 mLof 20% ammonium in methanol under vigorous stirringmaintaining the reaction mixture temperature below35-40C. The reaction mixture was kept at roomtemperature for 12 h, After the reactionended, 150 mL of water was added and the mixturewas heated up to 70-75C by water bath till the gasevolution stopped. After cooling the precipitate wasfiltered off, washed with water, and dried. Yield 89%(61.8 g), Rf 0.45, mp 137 (136-137 [21]). Found,%: 52.09; H 4.31; N 20.30; S 23.30. C6H6N2S.Calculated, %: 52.15; H 4.38; N 20.27; S 23.20.

According to the analysis of related databases, 100-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Khromova, N. Yu.; Malekin; Kutkin; Kondrat’Ev; Russian Journal of General Chemistry; vol. 85; 10; (2015); p. 2295 – 2298; Zh. Obshch. Khim.; vol. 85; 10; (2015); p. 1663 – 1666,4;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.Recommanded Product: 100-70-9

Compound 18 was synthesized according to the procedures reported in the literature (J. Org. Chem. 1998, 63, 1740-1741) as shown in Scheme 38.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-70-9, Picolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; PURDUE PHARMA L.P.; NI, Chiyou; SHAO, Bin; TAFESSE, Laykea; YAO, Jiangchao; YU, Jianming; ZHOU, Xiaoming; WO2012/35421; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-70-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example A8; Under nitrogen atmosphere, a solution of anhydrous cerium chloride (5.0 g) in tetrahydrofuran (40 mL) was stirred at room temperature overnight. To the reaction mixture was added dropwise a solution of 1.04M methyl lithium in diethylether (19 mL) under cooling in a dry ice/acetone bath over a period of 20 minutes. The mixture was stirred at the same temperature for 30 minutes, and to the reaction mixture was added dropwise a solution of 2- cyanopyridine (685 mg) in tetrahydrofuran (1 mL) . After warming to room temperature over a period of 5 hours, to the reaction mixture was added an aqueous 28% ammonia solution (12.5 mL) under ice-cooling. The mixture was filtered through Celite to remove precipitates. The filtrate was dried over sodium sulfate and filtered. The filtrate was concentrated in vacuo to give 1-methyl-l- (2- pyridyl) ethylamine (863 mg) as a brown oil. MS(APCI)m/z; 137 [M+H]+

According to the analysis of related databases, 100-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; WO2008/4698; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem