Category: 1000340-35-1

Li, Jian-Yuan’s team published research in Bioconjugate Chemistry in 2019 | CAS: 1000340-35-1

4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

《Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis》 was written by Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde And the article was included in Bioconjugate Chemistry on August 21 ,2019. The article conveys some information:

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets. After reading the article, we found that the author used 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)

4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 1000340-35-1

With the rapid development of chemical substances, we look forward to future research findings about 1000340-35-1.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1000340-35-1, name is 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde, molecular formula is C8H5BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1000340-35-1

Sodium borohydride (0.098 g, 0.0026 mole) was added in portions to a stirred suspension of 4-bromo-lH-pyrrolo [2, 3-b] pyridine-3-carboxaldehyde (0.4 g, 0.0017 mol) in methanol (15 inL) to obtain a clear solution. After completion of reaction, the reaction mixture was concentrated to obtain a residual mass that was diluted with water (25 mL) and extracted with ethyl acetate (25 mL x 3). The organic extracts were combined, dried over anhydrous Na2SC>4 and concentrated under vacuum to obtain the title compound. Yield: 0.35 g; – NMR (DMSO- , 400 MHz) delta ppm: 4.76 – 4.77 (d, J = 4.82 Hz, 2H), 4.86 -(bs, 1H), 7.28 – 7.29 (d, J = 5.04 Hz, 1H), 7.46 – 7.48 (d, J = 8 Hz, 1H), 8.02 – 8.03 (d, J = 5 Hz, 1H), 11.82 (s, 1H); Mass (m/z): 227.0 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 1000340-35-1.

Reference:
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; BADANGE, Rajesh Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; JASTI, Venkateswarlu; (172 pag.)WO2018/42362; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem