Category: 1000342-71-1

Related Products of 1000342-71-1, Adding some certain compound to certain chemical reactions, such as: 1000342-71-1, name is 6-Bromo-1H-pyrrolo[3,2-c]pyridine,molecular formula is C7H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1000342-71-1.

a) Preparation of intermediate 79A stirred solution of 6-bromo-5-azaindole (3.00 g, 15.2 mmol) in DMF (30 ml) at ambient temperature was treated with powdered potassium hydroxide (3.42 g, 60.9 mmol). After stirring for 15 minutes, iodine (4.25 g, 16.74 mmol) was added and the resulting mixture was stirred for 18 hours. The mixture was concentrated in vacuo and the residue triturated with water to afford the desired product as a cream solid (5.06 g, 100%).LCMS (Method C): Rt= 2.92 min, m/z [M+H]+= 322/324

According to the analysis of related databases, 1000342-71-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; CLARK, David, Edward; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; PANCHAL, Terry, Aaron; PRICE, Stephen, Colin; MONTANA, John, Gary; WO2015/44267; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1000342-71-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1000342-71-1, name is 6-Bromo-1H-pyrrolo[3,2-c]pyridine. A new synthetic method of this compound is introduced below.

General procedure: To a stirred solution of 5-bromo-1H-pyrrolo[2,3-c]pyridine (1.5 g, 7.61 mmol) in DMF (15 mL), KOH (1.27 g, 11.42 mmol) was added at RT. The resulting solution was stirred for 30 min. Then, fert-butyl 3- (bGammaomomethyl)piperidine-1-caoxylate (3.17 g, 22.84 mmol) was added at 0 C, and stirred at RT for 16h. The reaction mixture was diluted with water (70 mL) and extracted with EtOAc (2 x 70 mL), the combined organic layers were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash column chromatography and eluted with 30% EtOAc/ pet ether to obtain the title compound (1.6 g, 54%) as an off white solid. LC-MS (method 1): Rt =2.47 min; m/z = 394.24 (M+H+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1000342-71-1, 6-Bromo-1H-pyrrolo[3,2-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1000342-71-1, 6-Bromo-1H-pyrrolo[3,2-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1000342-71-1, blongs to pyridine-derivatives compound. Product Details of 1000342-71-1

To a stirred solution of 6-bromo-1H-pyrrolo[3,2-c]pyridine (2.0 g, 10.2 mmol) in DCM (40 mL), anhydrous AICI3 (2.713 g, 20.4 mmmol) was added at 0C. The resulting mixture was stirred for 15 minutes at RT and then butyryl chloride (2.162 g, 20.4 mmol) was added. The reaction mixture it was allowed to stir at RT for 16h. The mixture was diluted with MeOH and the solution was concentrated under reduced presure. The crude compound was basified to pH~8 using aq. saturated NaHC03 solution and extracted with EtOA. The combined organic phases were dried over anhydrous NaSOt, filtered and concentrated under reduced pressure. The crude compound was triturated with diethyl ether, filtered and dried under vacuum to afford the title compound (1.5 g, 55%) as an off-white solid. LC-MS (method 16): Rt = 1.92 min; m/z = 267.14 (M+H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1000342-71-1, 6-Bromo-1H-pyrrolo[3,2-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem