As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1001412-41-4, name is 5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H4Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 5,7-Dichloro-1H-pyrrolo[2,3-c]pyridine
Step B: 5,7-dichloro-1 -methyl-pyrrolo[2,3-clpyridine: A solution of 5,7-dichloro-1 H-pyrrolo[2,3-c]pyridine (2 g, 10.693 mmol) in dry N,N- dimethylformamide (50 mL) was treated with sodium hydride (0.77 g, 16.04 mmol) at ambient temperature and reaction stirred for 15 min at this temperature. The reaction mixture was cooled to 0C and iodomethane (1 mL, 16.04 mmol) was added, and the mixture allowed to stir 18 hours at ambient temperature. The reaction mixture was then quenched with NH4CI saturated solution, extracted with ethyl acetate (three times), and the combined organic layer was dried over Na2S04, filtered and evaporated under vacuum. Purification by Combi flash chromatography with a column of 24g and a gradient cyclohexane:0-100% ethyl acetate to give the title compound as a yellow solid (1.8 g, 84%).
With the rapid development of chemical substances, we look forward to future research findings about 1001412-41-4.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; BIGOT, Aurelien; HALL, Roger Graham; JEANGUENAT, Andre; LUKSCH, Torsten; RENDLER, Sebastian; WO2013/156431; (2013); A1;,
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