Category: 1001413-01-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1001413-01-9, name is 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C13H9F2NO3

The carboxylic derivative 3 (300 mg, 1.13 mmcl) and the amine 2(168 mg, 1.13 mmcl) were combined through a condensation reaction in presence of thecondensing agent TBTU (363 mg, 1.13 mmol). The solvents were evaporated under reduced pressure and the crude product was purified by flash chromatography over silica gel, using 0 – 4% MeOH as a gradient in CHCI3, to obtain pure SST143 as a white solid (210 mg, 0.53 mmol, 47% yield). mp: 285-288 00 1H-NMR (400 MHz, DMSO-d6): 6 3.48 (5, 2H, CH2 indole); 5.28(5, 2H, CH2); 6.68 (dd, 1 H, J= 6.8, 7.2 Hz, Ar); 6.77 (d, 1 H, J= 8.4 Hz, Ar); 7.20-7.23 (m, 1H, Ar); 7.40-7.52 (m, 3H, Ar); 7.66 (5, 1H, Ar); 8.29 (dd, 1H, J= 2.2,6.8 Hz, Ar); 8.46 (dd, 1H, J= 2.2, 6.8 Hz, Ar); 10.33 (5, 1H, NH), 11.87 (5, 1H,NH) ppm. 13C-NMR (101 MHz, DMSO-d6): 6 176.23, 161.54, 160.73, 150.35,147.90, 143.78, 143.42, 139.86, 134.02, 132.32, 126.40, 124.90, 120.35,119.02, 117.74, 117.25, 116.90, 109.10, 107.22, 51.45, 36.02 ppm. 19F-NMR (376 MHz; DMSO-d6): 6-138.17 (d, iF, J= 24 Hz); -139.76 (d, iF, J= 24 Hz) ppm. Anal. Calcd for 021H15F2N303: 0, 63.80%; H, 3.82%; N 10.63%; Found: C, 63.72%; H, 3.55%; N, 10.50%

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Reference:
Patent; INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.; SESTITO, Simona; DANIELE, Simona; MARTINI, Claudia; RAPPOSELLI, Simona; PURICELLI, Guido; (63 pag.)WO2016/198597; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1001413-01-9, Adding some certain compound to certain chemical reactions, such as: 1001413-01-9, name is 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid,molecular formula is C13H9F2NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001413-01-9.

Compound 25.5 (0.168 grams, 0.749), l-(3,4-difluoro-benzyl)-2-oxo-l,2-dihydro- pyridine-3-carboxylic acid (0.200 grams, 0.749 mmol), N-(3-dimethylaminopropyl)-N’- ethylcarbodiimide hydrochloride (0.172 grams, 0.899 mmol) and 1-hydroxybenzotriazole monohydrate (0.138 grams, 0.899 mmol), and diisopropylethylamine (0.652 ml, 3.75 mmol) were dissolved in dimethylacetamide (4 ml) and stirred at ambient temperature for 17 hours. The reaction was diluted with EtOAc, washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered, and concentrated. The residue was purified by column chromatography on silica (3% MeOH/DCM) to yield Compound 25.6 (0.066grams, 0.140 mmol, 19%). ES (+) MS m/e = 472 (M+l). IH NMR (400 MHz, DMSO-d6) delta ppm 4.59 (m, 2 H) 5.20 (m, 2 H) 6.58 (m, 1 H) 7.14 (m, 2 H) 7.40 (m, 2 H) 8.00 (m, 1 H) 8.08 (m, 1 H) 8.22 (m, 1 H) 8.29 (m, 2 H) 8.39 (m, 2 H) 8.84 (m, 1 H) 10.11 (m, 1 H) 12.06 (m, 1 H).

According to the analysis of related databases, 1001413-01-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.; WO2008/5457; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1001413-01-9, 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1001413-01-9, blongs to pyridine-derivatives compound. SDS of cas: 1001413-01-9

Compound 53.3 (0.094 grams, 0.204 mmol) was dissolved in methanol (5 ml). A scoop of palladium on carbon (Degussa Type ElOl NEAV wet) was added followed by 4.0M HCl p-Dioxane (1 ml). This mixture was placed on a Parr shaker at 40 psi for 48 hours, filtered through Celite, and concentrated. This residue was mixed with Compound 20.2 (54 milligrams, 0.204 mmol), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (47 milligrams, 0.245 mmol) and 1-hydroxybenzotriazole monohydrate (38 milligrams, 0.245 mmol), dissolved in N,N-dimethylformamide (2 ml) and diisopropylethylamine (0.178 ml, 1.02 mmol) was added. The reaction was stirred at ambient temperature for 16 hours and then flooded with ethyl acetate, washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered and concentrated to yield Compound 53.4 (2.8 milligrams, 0.006 mmol). ES (+) MS m/e = 461 (M+H). IH NMR (400 MHz, MeOH-d4) delta ppm 4.60 (s, 2 H) 5.14 (s, 2 H) 6.49 (m, 1 H) 6.60 (m, 1 H) 7.11 (m, 2 H) 7.23 (m, 1 H) 7.37 (m, 1 H) 7.83 (m, 1 H) 7.96 (m, 1 H) 8.29 (m, 1 H) 8.40 (m, 1 H) 8.69 (d, J=8.31 Hz, 1 H).

The synthetic route of 1001413-01-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.; WO2008/5457; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1001413-01-9 ,Some common heterocyclic compound, 1001413-01-9, molecular formula is C13H9F2NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Thiophene-2-methanamine (0.562 g, 0.00496 mol; Acros) and l-(3,4-difluoro-benzyl)- 2-oxo-l,2-dihydro-pytauidine-3-carboxylic acid (1.32 g, 0.00496 mol) and N,N,N,N’-tetramethyl- O-(7-azabenzotriazol-l-yl)uronium hexafluorophosphate (2.08 g, 0.00546 mol; Applied Biosystems) was dissolved in N,N-dimethylformamide (15.0 mL, Acros). To this was added N,N-diisopropylethylamine (4.32 mL, 0.0248 mol; Acros) and the reaction was stirred overnight at room temperature. The reaction was evaporated to dryness, then partitioned between 5% citric acid, ethyl acetate. The organic layer was washed with saturated sodium chloride, dried with sodium sulfate, filtered and concentrated. The residue was purified on preparative HPLC. Appropriate fractions were combined and evaporated to give the product in 1.04 g yield. MS m/z= 361.06 M+H.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1001413-01-9, 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.; WO2008/5457; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1001413-01-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1001413-01-9, name is 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Compound 57.5 (0.1 grams, 0.277 mmol) was suspended in toluene (2 ml) and chilled to 0 0C. 1.0M diisobutylaluminium hydride (0.304 ml) was added drop-wise and the reaction stirred overnight, allowing it to warm to room temperature. The reaction was quenched with a saturated aqueous solution of Rochelle’s salt, filtered through Celite, the layers separated, the organic layer washed with brine, dried over sodium sulfate, filtered, and concentrated. This residue was mixed with l-(3,4-Difluoro-benzyl)-2-oxo-l,2-dihydro-pyridine-3-carboxylic acid (73 milligrams, 0.277 mmol), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (64 milligrams, 0.332 mmol), 1-hydroxybenzotriazole monohydrate (51 milligrams, 0.332 mmol), dissolved in N,N-dimethylformamide (2 ml) and diisopropylethylamine (0.241 ml, 1.39 mmol) was added. The reaction was stirred at ambient temperature for 16 hours and then flooded with ethyl acetate, washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered and concentrated to yield Compound 57.6 (90.7 milligrams, 0.148 mmol). ES (+) MS m/e = 613 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1001413-01-9, 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Patent; SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.; WO2008/5457; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem