Category: 1003043-40-0

Ye, Bihai; Yao, Jian; Wu, Changhui; Zhu, Huilong; Yao, Weijun; Jin, Lili; Dou, Xiaowei published an article on February 18 ,2022. The article was titled 《Rhodium-Catalyzed Asymmetric Conjugate Pyridylation with Pyridylboronic Acids》, and you may find the article in ACS Catalysis.HPLC of Formula: 1003043-40-0 The information in the text is summarized as follows:

In this study, the rhodium-catalyzed asym. conjugate pyridylation of α,β-unsaturated carbonyl compounds with pyridylboronic acids was reported. The bifunctional chiral amide-diene ligand, which dramatically accelerated the reaction via possible H-bonding activation, and alc. solvent, which significantly inhibited the competing protodeboronation of pyridylboronic acids under rhodium catalysis, worked in concert to promote the reaction, thus enabling production of the pyridylation products in high yields (up to 99%) with good enantioselectivities (up to >99% ee). The experimental process involved the reaction of (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0HPLC of Formula: 1003043-40-0)

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 1003043-40-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase》 were Vishwanath, Divakar; Girimanchanaika, Swamy S.; Dukanya, Dukanya; Rangappa, Shobith; Yang, Ji-Rui; Pandey, Vijay; Lobie, Peter E.; Basappa, Basappa. And the article was published in Molecules in 2022. Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid The author mentioned the following in the article:

Novel PARP inhibitors with selective mode-of-action have been approved for clin. use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells, wherein seven compounds were observed to possess significant IC50 values in the range of 1.4 to 25 μM. Furthermore, compound 5u, inhibited the viability of MCF-7 cells with an IC50 value of 1.4μM, when compared to Olaparib (IC50 = 3.2 μM). Compound 5s also decreased cell viability in MCF-7 and MDA-MB-231 cells with IC50 values of 15.3 and 19.2 μM, resp. Treatment of MCF-7 cells with compounds 5u and 5s produced PARP cleavage, H2AX phosphorylation and CASPASE-3 activation comparable to that observed with Olaparib. Compounds 5u and 5s also decreased foci-formation and 3D Matrigel growth of MCF-7 cells equivalent to or greater than that observed with Olaparib. Finally, in silico anal. demonstrated binding of compound 5s towardsthe catalytic site of PARP-1, indicating that these novel oxadiazoles synthesized herein may serve as exemplars for the development of new therapeutics in cancer. In the part of experimental materials, we found many familiar compounds, such as (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid)

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zurwerra, Didier; Quetglas, Vincent; Kloer, Daniel P.; Renold, Peter; Pitterna, Thomas published an article in Organic Letters. The title of the article was 《Synthesis and Stability of Boratriazaroles》.Synthetic Route of C6H7BClNO2 The author mentioned the following in the article:

We describe the synthesis and stability anal. of novel boratriazaroles that can be viewed as bioisosteres of imidazoles or pyrazoles. These heterocycles could conveniently be obtained by condensing a boronic acid and amidrazone 1 in various solvents. A detailed stability anal. of selected compounds at different pH values as a function of time led to the identification of steric hindrance around the boron atom as a key element for stabilization. In addition to this study using (6-Chloro-5-methylpyridin-3-yl)boronic acid, there are many other studies that have used (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Synthetic Route of C6H7BClNO2) was used in this study.

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C6H7BClNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: (6-Chloro-5-methylpyridin-3-yl)boronic acidOn March 27, 2014, Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain published an article in Journal of Medicinal Chemistry. The article was 《First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump》. The article mentions the following:

Overexpression of efflux pumps is an important mechanism of bacterial resistance that results in the extrusion of antimicrobial agents outside the bacterial cell. Inhibition of such pumps appears to be a promising strategy that could restore the potency of existing antibiotics. The NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrates, such as hydrophilic fluoroquinolones, leading to a multidrug-resistance phenotype. Here, 150 heterocyclic boronic species were evaluated for their activity against susceptible and resistant strains of S. aureus. Twenty-four hit compounds, although inactive when tested alone, were found to potentiate ciprofloxacin activity by a 4-fold increase at concentrations ranging from 0.5 to 8 μg/mL against S. aureus 1199B, which overexpresses NorA. Boron-free analogs showed no biol. activity, thus revealing that the boron atom is crucial for biol. activity. This work describes the first reported efflux pump inhibitory activity of boronic acid derivatives In the experiment, the researchers used (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid)

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hedou, Damien; Voisin-Chiret, Anne Sophie published an article in European Journal of Organic Chemistry. The title of the article was 《Br vs. TsO Chemoselective Suzuki-Miyaura Cross-Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2,3,5-Trisubstituted Pyridines》.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid The author mentioned the following in the article:

Br vs. TsO chemoselective pallado-catalyzed Suzuki-Miyaura reaction has been developed from the 5-bromo-2-tosyloxynicotinaldehyde for the preparation of polysubstituted pyridines. This methodol. has been applied for the preparation of a terpyridine aldehyde, as a versatile precursor of potential Mcl-1 (Induced myeloid leukemia cell differentiation protein) inhibitors. The synthesis of pyridoclax (I), our lead compound which demonstrated efficacy for the treatment of chemoresistant ovarian cancer, has also been achieved via the palladium-catalyzed cross-coupling reaction in 5 steps from 3,5-dibromo-2-hydroxypyridine with 50% overall yield.(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid) was used in this study.

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells》 was published in Journal of Asian Natural Products Research in 2018. These research results belong to Yang, Qian-Hao; Jiang, Cheng-Shi; Jin, Tao; Xu, Jin-Fang; Qu, Ting-Li; Guo, Yue-Wei; Zhao, Zheng-Bao. Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid The article mentions the following:

A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki -Miyaura reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma (NSCLC) A549 cells. Interestingly, most of derivatives showed similar cytotoxicity to Tet against NSCLC A549 cells, and particularly, compounds Y5, Y6, Y9 and Y11 showed the most significant cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM. The present study is expected to contribute to the future design of more effective anticancer agents in lung cancer chemotherapy. The results came from multiple reactions, including the reaction of (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid)

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem