Category: 100397-96-4

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100397-96-4, name is 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, molecular formula is C13H10BrNO, molecular weight is 276.13, as common compound, the synthetic route is as follows.Computed Properties of C13H10BrNO

1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (4 g, 14.5 mmol) was heated at reflux in DMF-DMA (13 ml) for 1 hour and concentrated. The residue was dissolved in MeOH, and to this, methylhydrazine in water (40%) (3 ml) was added. Then the reaction mixture was heated at 65 C. for 1 hour. When LC/MS indicated the reaction was completed. The mixture was concentrated and purified by column chromatography over silica gel using (PE:EA=10:1-1:1) to give 3 g of crude product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100397-96-4, 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; SU ZHOU JING HONG BIOTECH CO., LTD.; CAI, Zhen-Wei; ZHOU, Ding; LIN, Yougang; CHEN, Ping; US2013/158031; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100397-96-4, name is 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, molecular formula is C13H10BrNO, molecular weight is 276.13, as common compound, the synthetic route is as follows.Computed Properties of C13H10BrNO

1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (4 g, 14.5 mmol) was heated at reflux in DMF-DMA (13 ml) for 1 hour and concentrated. The residue was dissolved in MeOH, and to this, methylhydrazine in water (40%) (3 ml) was added. Then the reaction mixture was heated at 65 C. for 1 hour. When LC/MS indicated the reaction was completed. The mixture was concentrated and purified by column chromatography over silica gel using (PE:EA=10:1-1:1) to give 3 g of crude product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100397-96-4, 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; SU ZHOU JING HONG BIOTECH CO., LTD.; CAI, Zhen-Wei; ZHOU, Ding; LIN, Yougang; CHEN, Ping; US2013/158031; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100397-96-4, name is 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, molecular formula is C13H10BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone

Step B 1-(4-Bromophenyl)-2-(4-pyridyl)-ethan-1,2-dione A mixture of 200 mg (0.725 mmol) of l-(4-bromophenyl)-2-(4-pyridyl)-ethanone (from Step A) and 81 mg (0.725 mmol) of selenium(IV) oxide, and 5.5 mL of glacial acetic acid was heated to 135 C. for 2 h. After being cooled to room temperature, the reaction mixture was partitioned between saturated aqueous potassium carbonate and ethyl acetate. The aqueous layer was extracted twice more more with ethyl acetate. The organic layers were combined and washed with water and brine and dried over anhydrous sodium sulfate. Volatiles were removed under reduced pressure and the residue was flash chromatographed over silica gel (gradient elution 2-4% MeOH in DCM) to yield 100 mg of the titled compound, homogeous by TLC; mass spectrum (CI) m/e 290, 292 (M+1)+.

With the rapid development of chemical substances, we look forward to future research findings about 100397-96-4.

Reference:
Patent; Merck & Co., Inc.; US5955480; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100397-96-4, name is 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, molecular formula is C13H10BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone

Step B 1-(4-Bromophenyl)-2-(4-pyridyl)-ethan-1,2-dione A mixture of 200 mg (0.725 mmol) of l-(4-bromophenyl)-2-(4-pyridyl)-ethanone (from Step A) and 81 mg (0.725 mmol) of selenium(IV) oxide, and 5.5 mL of glacial acetic acid was heated to 135 C. for 2 h. After being cooled to room temperature, the reaction mixture was partitioned between saturated aqueous potassium carbonate and ethyl acetate. The aqueous layer was extracted twice more more with ethyl acetate. The organic layers were combined and washed with water and brine and dried over anhydrous sodium sulfate. Volatiles were removed under reduced pressure and the residue was flash chromatographed over silica gel (gradient elution 2-4% MeOH in DCM) to yield 100 mg of the titled compound, homogeous by TLC; mass spectrum (CI) m/e 290, 292 (M+1)+.

With the rapid development of chemical substances, we look forward to future research findings about 100397-96-4.

Reference:
Patent; Merck & Co., Inc.; US5955480; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 100397-96-4 ,Some common heterocyclic compound, 100397-96-4, molecular formula is C13H10BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2) (E)-1-(4-bromophenyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one A mixture of 1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (500 mg, 1.811 mmol) and 1,1-dimethoxy-N,N-dimethylmethanamine (1 g, 8.39 mmol) in DMF (9 ml) was heated to 100 C. for about 6 h. Removal of the solvent under reduced pressure provided (E)-1-(4-bromophenyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one (640 mg, 1.546 mmol, 85% yield) as a red oil which was used in the next step without further purification. LC-MS (Method B): m/z 331 (M+H), RT: 1.37 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100397-96-4, its application will become more common.

Reference:
Patent; GENESTE, Herve; TURNER, Sean Colm; OCHSE, Michael; DRESCHER, Karla; BLACK, Lawrence A.; JANTOS, Katja; US2014/148461; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem