Category: 1008304-85-5

Reference of 1008304-85-5 , The common heterocyclic compound, 1008304-85-5, name is 2-Chloro-6-methoxypyridin-4-amine, molecular formula is C6H7ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Chloro-6-methoxy-pyridin-4-amine (2 g, 12.61 mmol), 3-pyridylboronic acid(1.55 g, 0.01 mol), Pd(amphos)C12 (0.73 g, 0.63 mmol) and K2003 (3.49 g,0.03 mol) were dissolved in MeCN (6 ml) and water (2 ml) and the mixturewas heated in the microwave reactor at 130 00 for 30 mm. The mixture was filtered and the organic layer was evaporated. The resulting residue was dissolved in EtOAc, washed with water, brine, dried over Mg504 and concentrated to give the product as a solid (1 .2 g 47%). MS ES+ m/z 202 [M+H].

The synthetic route of 1008304-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SPRINT BIOSCIENCE AB; LINDSTROeM, Johan; FORSBLOM, Rickard; RAHM, Fredrik; VIKLUND, Jenny; (103 pag.)WO2019/38384; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1008304-85-5, 2-Chloro-6-methoxypyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1008304-85-5, blongs to pyridine-derivatives compound. Computed Properties of C6H7ClN2O

To a solution of 2-chloro-6-methoxypyridin-4-amine (790 mg, 5.00 mmol) in CH3CN (5 mL)was added water (5 mL) and conc. HCI (5 mL). Then a solution of NaNO2 (690 mg, 10.0mmol) in water (5 mL) was added dropwise at 0 C. After stirred at 0 C for 10 mm a solution of KI (1.66 g, 10.0 mmol) in water (5 mL) was added dropwise at 0C. The mixture was stirred at 0 C for 20 mm. Then, the reaction was quenched with sat. Na2S2O3 solution (50 mL). EtOAc (20 mL x 3) was added to extract desired compound. The combined organiclayers were washed with brine (20 mL), dried over Na2SO4 and concentrated. The residue was purified by column chromatography (PE)to give the title compound (1.1 g, yield 82%) as white solid.D490 1H NMR (300 MHz, CDCI3): O 7.26 (s, 1H), 7.07 (s, 1H), 3.91 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1008304-85-5, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; DING, Xiao; JIN, Yun; LIU, Qian; REN, Feng; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; WANG, Hailong; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (573 pag.)WO2017/12576; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem