Category: 101012-32-2

Adding a certain compound to certain chemical reactions, such as: 101012-32-2, (2-Chloropyridin-3-yl)acetonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Chloropyridin-3-yl)acetonitrile, blongs to pyridine-derivatives compound. name: (2-Chloropyridin-3-yl)acetonitrile

To a solution of 2-(2-methylpyridin-3-yl)acetoni- trile (1.0 g, 6.6 mmol) and methyl acrylate (1.8 mE, 19.9 mmol) in THF (10 mE) at 0 C. was added potassiumtert-butoxide (8.6 mE, 8.6 mmol, 1 M in THF) and the resulting reaction mixture stirred at 25 C. for 3 h. The mixture was partitioned between H20 (100 mE) and EtOAc (80 mE), the aqueous layer further extracted with EtOAc (2×80 mE), combined organics dried (Na2SO4) and the solvent removed in vacuo. The residue was purified by colunm chromatography (normal silica, mesh size: 60-120, 0% to 0.5% MeOH in DCM) to give methyl 5-(2-chloro- pyridin-3-yl)-5-cyano-2-oxocyclohexane- 1 -carboxylate (1.2 g, 63%) as a yellow liquid.ECMS (Method F): mlz 293 (M+H) (ESj, at 1.97 mm UV active.

The synthetic route of 101012-32-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Heptares Therapeutics Limited; Brown, Giles Albert; Congreve, Miles Stuart; Pickworth, Mark; Tehan, Benjamin Gerald; (107 pag.)US2018/105491; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101012-32-2, name is (2-Chloropyridin-3-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H5ClN2

INTERMEDIATE 14 2-[(2-Fluoro-4-iodophenyl)amino1thieno[2,3-?]pyridme-3-carbonitrileTo a solution of (2-chloropyridin-3-yl)acetonitrile {Intermediate 2; 700 mg, 4.59 mmol) and Intermediate 4 (1.28 g, 4.60 mmol) in dry DMSO (15 mL) was added sodium hydride (202 mg, 60% in mineral oil, 5.06 mmol). The mixture was stirred at room temperature for 15 minutes before heating to 9O0C for four hours. The reaction mixture was poured into water (80 mL) and the solid precipitate filtered and washed with water/ ethanol (2:1 mixture, 50 mL) followed by diethyl ether/hexane (1:1 mixture, 20 mL). The solid was dried in a vacuum oven and recrystallised from ethanol/water to give the title compound as a pale brown solid (800 mg, 45%). ?H (DMSOd6) 10.40 (IH, s), 8.37 (IH, dd, J 1.3, 4.6 Hz), 7.83-7.81 (2H, m), 7.64 (IH, d, J 8.3 Hz), 7.44 (IH, dd, J 4.7, 8.0 Hz), 7.33 (IH, dd, J 8.3, 8.3 Hz). LCMS RT 3.08 minutes, (ES”) 394 (M-H)”, (ES+) 396 (M+H)+.

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Reference:
Patent; UCB PHARMA S.A.; WO2009/13462; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem