Category: 1010120-55-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1010120-55-4, name is 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine, the common compound, a new synthetic route is introduced below. Safety of 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine

4-[ 4-( 4,4,5,5-Tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-benzyl]-thiomorpholine-1, 1-dioxide(1.1eq.) was added to a solution of 5-bromo-[1,2,4]triazolo[1,5-a]pyrid in-2-ylamine (4:1). K2C03 (2eq.) and PdCbdppf (0.03 eq.) were added to the solution. The resulting mixture was then heated in anoil bath at 90C for 16h under N 2. Water was added and the solution was extracted with ethyl acetate.The organic layers were dried over anhydrous MgS04 and evaporated in vacuo. The final compoundwas obtained after purification by flash chromatography.[00162] 1H (400 MHz, CDCh) 8 7.94-7.92 (d, 2H), 7.52-7.48 (m, 3H), 7.37-7.34 (m, 1H), 7.02-7.00(m, 1H), 6.00 (d, 2H), 3.76 (d, 2H), 3.15-3.13 (m, 4H), 2.93-2.91 (m, 4H).[00163] m/z 358.2 (M+H+, 100%).

The synthetic route of 1010120-55-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS NV; VAN ‘T KLOOSTER, Gerben Albert Eleutherius; BRYS, Reginald Christophe Xavier; VAN ROMPAEY, Luc Juliaan Corina; NAMOUR, Florence Sylvie; WO2013/189771; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1010120-55-4, 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H5BrN4, blongs to pyridine-derivatives compound. COA of Formula: C6H5BrN4

3-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine (purchased from Mesh Mall) 30.00 g (0.14 mol) was added to a 1L three-necked bottle,4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzyl) is added thereto in this orderThiomorpholine 1,1-dioxide 58.50 g (0.15 mol), dioxane 400 ml, potassium carbonate 58.60 g (0.42 mol), water 100 ml, Pd(dppf)Cl2 5.78 g (0.007 mol).Under argon protection, the mixture was warmed to 90 C and the reaction was stirred for 16 h.After the reaction is completed, cool to room temperature, add 400 ml of dichloromethane, then wash twice with water, 800 ml each time, and concentrate the organic layer to dryness.The residue was purified by column chromatography (eluent: dichloromethane:methanol = 100:1) to give the title product as a pale yellow solid, 27.2 g, 54% yield, purity 96%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1010120-55-4, 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; China Pharmaceutical Research And Development Center Co., Ltd.; Yin Huijun; Yan Xu; Zong Libin; Dong Liuxin; Han Yachao; Xi Qingchuan; Dou Haoshuai; Mi Zhen; Yang Yan; (30 pag.)CN107880038; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1010120-55-4, Adding some certain compound to certain chemical reactions, such as: 1010120-55-4, name is 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine,molecular formula is C6H5BrN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1010120-55-4.

A mixture of 5-bromo-[l,2,4]triazolo[l,5-a]pyridin-2-ylamine (1 eq), Cs2CO3 (5eq), Pd(OAc)2 (0.1 eq), Xantphos (0.1 eq.), 4-Iodo-benzoic acid methyl ester (1.5 eq) and 1,4-dioxane was sonicated for 5 minutes under nitrogen. Afterwards, the reaction was left in a sealed tube at 1000C or in a flasked equipped with a cooling system for 5 hrs. The crude mixture was extracted with ethyl acetate and the extracts were combined, washed with water and dried over anhydrous magnesium sulfate. The organic solvent was removed under high vacuum to yield the crude product. The crude product was purified by flash chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1010120-55-4, 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; BLANC, Javier; JOUANNIGOT, Nolwenn; HODGES, Alastair James; VAN ROMPAEY, Luc Juliaan Corina; FLETCHER, Stephen Robert; WO2010/10188; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1010120-55-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1010120-55-4, name is 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

1.1.3 General Procedure for Mono-Acylation to Afford Intermediate (4) To a solution of the 2-amino-triazolopyridine (3) (7.10 g, 33.3 mmol) in dry CH3CN (150 mL) at 5 C. is added Et3N (11.6 mL, 83.3 mmol) followed by cyclopropanecarbonyl chloride (83.3 mmol). The reaction mixture is then allowed to warm to ambient temperature and stirred until all starting material (3) is consumed. If required, further Et3N (4.64 mL, 33.3 mmol) and cyclopropanecarbonyl chloride (33.3 mmol) is added to ensure complete reaction. Following solvent evaporation in vacuo the resultant residue is treated with 7 N methanolic ammonia solution (50 mL) and stirred at ambient temp. (for 1-16 h) to hydrolyse any bis-acylated product. Product isolation is made by removal of volatiles in vacuo followed by trituration with Et2O (50 mL). The solids are collected by filtration, washed with H2O (2*50 mL), acetone (50 mL) and Et2O (50 mL), then dried in vacuo to give the required bromo intermediate (4).

According to the analysis of related databases, 1010120-55-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MENET, Christel Jeanne Marie; SMITS, Koen Kurt; US2010/331319; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem