Category: 101083-92-5

Adding a certain compound to certain chemical reactions, such as: 101083-92-5, 5-Nitro-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine, blongs to pyridine-derivatives compound. name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine

5-nitro-1 H-pyrrolo[2,3-b]pyridine (960 mg; 5.89 mmol) and K2C03 (1 .22 g; 8.83 mmol) are dissolved in DMF (20 mL) and stirred for 30 min at rt. lodomethane (SM-5b) (554 muL; 8.83 mmol) is added dropwise and stirring is continued at rt for 18 h. The reaction mixture is poured onto ice water, the resulting precipitate is collected by filtration and dried in vacuo to give 1 -methyl-5-nitro-1 H-pyrrolo[2,3-b]pyridine (HPLC-MS: tRet. = 0.98 min; MS (M+H)+ = 178; method 1 ).

The synthetic route of 101083-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STEURER, Steffen; DAHMANN, Georg; KERRES, Nina; KOEGL, Manfred; (210 pag.)WO2018/108704; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 101083-92-5 ,Some common heterocyclic compound, 101083-92-5, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 43; [0221] This example illustrates a preparation of 6-methoxy-2-(l-methyl-lH-pyrrolo[2,3- delta]pyridin-5-yl)isoindolin-l-one in an embodiment of the invention.; Step A: Synthesis of l-methyl-5-nitro-7-azaindole,; [0222] A solution of 5-nitro-7-azaindole (0.195 g, 1.2 mmol) in DMF (10 mL) was treated with NaH (60%, 0.057 g, 1.44 mmol), followed by iodomethane (0.204 g, 1.44 mmol). The reaction mixture was stirred at room temperature for 4.5 h, then poured into water (200 mL) and extracted with dichloromethane (3 chi100 mL). The combined organic layer was washed with brine (100 mL), dried over sodium sulfate, and concentrated. The crude product was purified by chromatography (silica, 50:50 ethyl acetate/hexanes) to yield l-methyl-5-nitro-7-azaindole (0.152 g, 72%) as a yellow solid: 1H NMR (500 MHz, CDCl3) delta 9.23 (d, J= 2.4 Hz, IH), 8.76 (d, J= 2.4 Hz, IH), 7.36 (d, J= 3.6 Hz, IH), 6.66 (d, J= 3.5 Hz, IH), 3.96 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 101083-92-5, 5-Nitro-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The United States of America, as represented by the Secretary, Department of Health and Human Services; Science Applications International Corporation (SAIC); Albany Molecular Research, Inc.; WO2009/42907; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 101083-92-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101083-92-5, name is 5-Nitro-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below.

2.675 g 5-Nitro-lH-pyrrolo[2,3-b]pyridine in 200 ml THF were hydrogenated over 1.0 g Platinum on carbon at atmospheric pressure for 3 hrs at RT (with thin layer chromatography (TLC) control). The catalyst was removed by filtration, the filtrate was evaporated and the residue purified by chromatography on silica in ethyl acetate /heptane mixtures. Yield 1.84 g

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101083-92-5, 5-Nitro-1H-pyrrolo[2,3-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/28617; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem