10128-72-0 | Pyridine-derivatives

Sources of common compounds: 10128-72-0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10128-72-0, Methyl 3-hydroxyisonicotinate.

Synthetic Route of 10128-72-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10128-72-0, name is Methyl 3-hydroxyisonicotinate, molecular formula is C7H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of chloride (200mg, 1.0 mmol, 1.0 eq), and phenol (153 mg, 1.0 mmol, 1.0 eq) in DMF (15 mE) was added K2C03 (414 mg, 3.0 mmol, 3.0 eq) and the reaction mixture was heated at 80-90 C. for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/MeOR) to give the alkylation product. MS: exact mass calculated for C15R13N303, 283.10; mlz found, 284 [M+R].

Reference:
Patent; Global Blood Therapeutics, Inc.; The Regents of the University of Califorina; Cytokinetics, Inc.; Metcalf, Brian; Chuang, Chihyuan; Warrington, Jeffrey; Paulvannan, Kumar; Jacobson, Matthew P.; Hua, Lan; Morgan, Bradley; US2015/344483; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of Methyl 3-hydroxyisonicotinate

The chemical industry reduces the impact on the environment during synthesis 10128-72-0, I believe this compound will play a more active role in future production and life.

Application of 10128-72-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10128-72-0, name is Methyl 3-hydroxyisonicotinate, molecular formula is C7H7NO3, molecular weight is 153.14, as common compound, the synthetic route is as follows.

[0166] To a solution of chloride (200 mg, 1.0 mmol, 1.0 eq), and phenol (153 mg, 1.0 mmol, 1.0 eq) in DMF (15 mL) was added K2C03 (414 mg, 3.0 nimol, 3.0 eq) and the reaction mixture was heated at 8 0-90 C for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/ MeOH) to give the alkylation product. MS: exact mass calculated for C15H13N303, 283.10; m/z found, 284 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 10128-72-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley; WO2013/102145; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of Methyl 3-hydroxyisonicotinate

The chemical industry reduces the impact on the environment during synthesis 10128-72-0, I believe this compound will play a more active role in future production and life.

Brief introduction of 10128-72-0

The synthetic route of 10128-72-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 10128-72-0, Methyl 3-hydroxyisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H7NO3, blongs to pyridine-derivatives compound. Formula: C7H7NO3

The title compound was prepared from methyl 3-hydroxy-4-pyridinecarboxylate (495 mg; 3.232 mmol) and compound 30a (967 mg; 3.394 mmol) according to the General Procedure XXII. In order to increase yield 2 equivalents of triphenylphosphine (1.98 g; 6.788 mmol) and DIAD (1.34 mL; 6.788 mmol) were used. Purification on silica-gel column chromatography (petroleum ether/AcOEt system) afforded the title product as a white solid (1.0 g; 2.375 mmol; 73% yield). NMR (CDCb, 400 MHz) delta: 8.37 (d, J = 4.8 Hz, 1H), 8.34 (s, 1H), 7.66 (d, J = 4.6 Hz, 1H), 7.25 (AlphaAlpha’BetaBeta’, J = 6.7 Hz, 2H), 7.17 (AlphaAlpha’BetaBeta’, J = 6.8 Hz, 2H), 5.36 (d, J = 7.8 Hz, 1H), 4.21- 4.01 (m, 3H), 3.98 (s, 3H), 3.07-2.93 (m, 2H), 1.42 (s, 9H).

The synthetic route of 10128-72-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ONCOARENDI THERAPEUTICS SP. Z O.O.; MAZUR, Marzena; KORALEWSKI, Robert; BOREK, Bartlomiej; OLEJNICZAK, Sylwia; CZESTKOWSKI, Wojciech J.; PIOTROWICZ, Michal C.; OLCZAK, Jacek P.; GOLEBIOWSKI, Adam A.; BARTOSZEWICZ, Agnieszka; MAZIARZ, Elzbieta; KOWALSKI, Michal L.; (274 pag.)WO2017/37670; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 10128-72-0

According to the analysis of related databases, 10128-72-0, the application of this compound in the production field has become more and more popular.

Application of 10128-72-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10128-72-0, name is Methyl 3-hydroxyisonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 30: methyl 3-I(4-phenylbutyl)oxyl-4-pyridinecarboxylate To a solution of methyl 3-hydroxy-4-pyridinecarboxylate (100 mg, 0.65 mmol) in DMF (2 ml) wasadded cesium carbonate (426 mg, 1 .31 mmol) followed by (4-bromobutyl)benzene (139 mg, 0.65mmol). The mixture was allowed to stir at room temperature for 16 h then concentrated in vacuo. The crude product was dissolved in DMSO (1 ml) and purified by MDAP using a formic modifier (Method G). Fractions containing desired product were loaded directly onto a 5g SCX-ll SPE column that had been preconditioned with isopropylalcohol. The column was eluted with isopropylalcohol (3 x 50 ml)then with a 10% ammonia inwater/90% isopropylalcohol solution. Desired product eluted in ammonia based fractions which were combined then concentrated under reduced pressure to give the title compound as a pale brown gum (1 23mg, 66%).LCMS (Method B): Rt= 1.19 mins, MH+ = 286.1

According to the analysis of related databases, 10128-72-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; BARKER, Michael David; CAMPBELL, Matthew; DIALLO, Hawa; DOUAULT, Clement; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; THOMAS, Pamela Joan; WILSON, David Matthew; WO2013/143597; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The important role of 10128-72-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10128-72-0, Methyl 3-hydroxyisonicotinate, other downstream synthetic routes, hurry up and to see.

Reference of 10128-72-0, Adding some certain compound to certain chemical reactions, such as: 10128-72-0, name is Methyl 3-hydroxyisonicotinate,molecular formula is C7H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10128-72-0.

Example A; 3, N-Dihydroxy-isonicotinamide To a stirred suspension of methyl 3-hydroxy-isonicotinate (176 g; 1.15 mol) in water/ice (50/50,1700 mL), was added hydroxylamine hydrochloride (127.9 g; 1.84 mol). The temperature fell to-5 C and then aqueous NAOH solution (454 mL, 28% w/v) was added dropwise keeping the temperature below 5 C during the addition. Hereafter the reaction mixture was stirred at ambient temperature for 1.5 h followed by heating to 60 C. At this temperature the pH was adjusted to 5.4 by the addition of aqueous hydrochloric acid (10 M) at which point a heavy precipitate forms. The reaction mixture was then stirred at ambient temperature followed by cooling to 5 C. THE pH was then adjusted to 4.0 by the addition of aqueous hydrochloric acid (10 M), and then was stirred whilst cold for 1,5 h. The crystals were filtered off, rinsed with water (3 x 100 mL), dried on the filter and then dried further at reduced pressure and 40 C overnight to give 3, N-dihydroxy-isonicotinamide (169.3 g, 96%; HPLC purity 98%) as a white solid. NMR data : H-NMR (DMSO-d6,250 MHz) 8 = 7.55 (1H, d, J=6 Hz); 8.11 (1H, d, J=6 Hz); 8.32 (1H, s); 9.56 (1H, s, broad peak); 11.50 (1H, s, broad peak) ppm.

Reference:
Patent; H. LUNDBECK A/S; WO2005/23820; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 10128-72-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10128-72-0, its application will become more common.

Related Products of 10128-72-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 10128-72-0 as follows.

[0163] To a DMF (15 mL) solution of the chloride (300 mg, 1.5 mmol, 1.0 eq) and phenol (230 mg, 1.5 mmol, 1.0 eq) was added K2C03 (621 mg, 4.5 mmol, 3.0 eq) and the reaction mixture was heated at 80-90 C for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/ MeOH) to give the alkylation product. MS: exact mass calculated for C15H13N303, 283.10; mlz found, 284 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10128-72-0, its application will become more common.