Category: 1014631-89-0

Electric Literature of 1014631-89-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1014631-89-0, name is 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Stage 3: N-(Dimethylsulphamoyl)-1-(pyridin-3-yl)-1H-pyrazole-4-carboxamide 0.250 g (1.32 mmol) of 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid was initially charged in 5 ml of tetrahydrofuran, and 0.43 ml (1.98 mmol) of N,N’-carbonyldiimidazole was added. The mixture was heated under reflux for 1 h. 0.246 g (1.98 mmol) of N,N-dimethylsulphonamide was dissolved in 3 ml of tetrahydrofuran and added dropwise at room temperature to the first solution. The mixture was stirred at room temperature for 10 min. After addition of 0.30 ml (1.98 mmol) of 1,8-diazabicyclo(5.4.0)undec-7-ene, the mixture was stirred at room temperature for 12 h. The solvent was removed on a rotary evaporator and water was added to the residue. The aqueous phase was extracted with dichloromethane. The organic phase was discarded and the aqueous phase was acidified with concentrated HCl. The precipitate formed was filtered off with suction. Yield: 0.120 g (30% of theory), logP1) (HCOOH) 1.03 1H NMR ((CD3)2SO): 2.89 (s, 6H), 7.58-7.62 (m, 1H), 8.24-8.27 (m, 1H), 8.38 (s, 1H), 8.60-8.62 (m, 1H), 9.10-9.11 (m, 1H), 9.22 (s, 1H) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1014631-89-0, 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid.

Reference:
Patent; Bayer CropScience AG; US2012/95023; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1014631-89-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1014631-89-0, name is 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Stage 3: (Pyridin-3-yl)-1H-pyrazole-4-carbonyl chloride hydrochloride; 4.00 g (21.15 mmol) of 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid were initially charged in approx. 100 ml of dichloromethane, and admixed with 2 drops of dimethylformamide under argon. 7.783 g (61.32 mmol) of oxalyl chloride were added dropwise and, after the end of the addition, the mixture was stirred at room temperature for 1 hour. The solution was concentrated, and the residue was admixed with approx. 10 ml of toluene and concentrated. This gave a colourless solid which was converted further immediately.

According to the analysis of related databases, 1014631-89-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer CropScience AG; US2011/118290; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem