Electric Literature of 1014720-73-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1014720-73-0, name is 6-Chloro-2-(pyridin-2-yl)pyrimidin-4-amine, molecular formula is C9H7ClN4, molecular weight is 206.63, as common compound, the synthetic route is as follows.
N-Isopropyl-2-pyridin-2-yl-pyrimidine-4,6-diamine Isopropylamine (181 mul, 2.42 mmol) was added to a solution of 6-chloro-2-pyridin-2-yl-pyrimidin-4-ylamine (100 mg, 0.48 mmol) in n-BuOH (1 ml) in a microwave tube and the mixture was heated at 180 C. for 1 h in the microwave. Isopropylamine (181 mul, 2.42 mmol) was added and the mixture was heated at 180 C. for a further 7 h in the microwave. The reaction mixture was diluted with water (1 ml) and concentrated in vacuo. The residue was dissolved in EtOAc (2 ml) and washed with saturated aqueous NaHCO3 solution (2 ml) and water (2 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by trituration from Et2O to give the title compound (32 mg, 29%).
The chemical industry reduces the impact on the environment during synthesis 1014720-73-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; VIFOR (INTERNATIONAL) AG; US2012/202806; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem