10177-08-9 | Pyridine-derivatives

Monge, A.’s team published research in Arzneimittel-Forschung in 1995 | CAS: 10177-08-9

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidOn March 31, 1995, Monge, A.; Martinez-Merino, V.; Simon, M. A.; Sanmartin, C. published an article in Arzneimittel-Forschung. The article was 《New 5H-[1,3]thiazolo[3,2-a]pyrido[3,2-e]pyrimidin-5-one derivatives as diuretics》. The article mentions the following:

A series of new 5H-[1,3]thiazolo[3,2-a]pyrido[3.2-3]pyrimidin-5-ones 3-substituted and/or 8,9-hydrogenated was prepared and tested for their diuretic, natriuretic and kaliuretic activities on male Wistar rats at a dosage of 25 mg/kg or less. Diuretic and saliuretic activities were strongly influenced by substituents in 3-position. Quant. structure-activity relationships show that electron withdrawn substituents in 3-position enhance both diuretic and saliuretic activities at 25 mg/kg. Global anal. of the variations introduced on pyridine, pyrimidine and thiazole rings of this tricyclic system showed an increases of diuretic and natriuretic activities when the formal charge on N9a and C9b increases. Potassium ion excretion also increases, although not as drastically a in the earlier cases. Regression equations were calculated by partial least squares method (PLS) and validated by the cross-validation (leave-one-out) technique. The results came from multiple reactions, including the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martinez-Merino, Victor’s team published research in Heterocycles in 1994 | CAS: 10177-08-9

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 10177-08-9 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Martinez-Merino, Victor; Gil, Maria J.; Gonzalez, Alberto; Zabalza, Jose M.; Navarro, Javier; Manu, Maria A. published an article on February 1 ,1994. The article was titled 《New 5-substituted derivatives of ethyl 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridine-2-acetate》, and you may find the article in Heterocycles.Application of 10177-08-9 The information in the text is summarized as follows:

A new series of Et 5-substituted 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridine-2-acetate I (R = NH2, Me, Ph, H, NO2) was prepared either a) directly by reaction of 5-substituted 2-chlorothio-3-pyridinecarbonyl chlorides with Et glycine or b) by oxidation of the corresponding 2-mercapto-3-pyridinecarboxamides. Some reactions of the free acids of I as starting materials are described. The experimental process involved the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Application of 10177-08-9)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 10177-08-9 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Church, Robert’s team published research in Journal of Organic Chemistry in 1995 | CAS: 10177-08-9

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 10177-08-9 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Church, Robert; Trust, Ronald; Albright, J. Donald; Powell, Dennis published an article in Journal of Organic Chemistry. The title of the article was 《New Synthetic Routes to 3-, 5-, and 6-Aryl-2-chloropyridines》.Application of 10177-08-9 The author mentioned the following in the article:

The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines, e.g., I (R1 = H, 3-pyridinyl, SO2Ph, etc., R2 = H, 3-F3CC6H4, 2,4-Cl2C6H3, 4-Ph, etc., R3 = H, Ph, 3-pyridinyl, etc.), via the facile preparation of 5-(dimethyamino)aryl-substituted pentadienyl nitriles and cyclization with hydrochloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well as the yields of chloropyridines were observed that depended on the position and degree of substitution in the aryl substituent. The arylpentadienyl nitriles Me2NCH:CCHCH:CArCN (Ar = 3-pyridinyl, 3-F3CC6H4, 3-MeOC6H4, Ph) could also be converted directly into the corresponding 2-aminopyridines. In the experiment, the researchers used 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Application of 10177-08-9)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 10177-08-9 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oostveen, E. A.’s team published research in Recueil des Travaux Chimiques des Pays-Bas in 1974 | CAS: 10177-08-9

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

The author of 《Pyrimidines. XLIII. Ring transformations in reactions of heterocyclic compounds with nucleophiles. IX. Conversion of N-methylpyrimidinium salts to pyridines by carbanions》 were Oostveen, E. A.; Van der Plas, H. C.. And the article was published in Recueil des Travaux Chimiques des Pays-Bas in 1974. Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid The author mentioned the following in the article:

On treatment with active methylene compounds in basic media the quaternary pyrimidinium salts were converted into pyridine derivatives. Thus, I(R = R1 = H; R = Ph, R1 = H, R = H, R1 = Ph) and CH2(CO2Et) with NaOH gave II. In the experiment, the researchers used many compounds, for example, 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 10177-08-9

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10177-08-9, 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid.

Reference of 10177-08-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10177-08-9, name is 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-Oxo-5-phenyl-l,2-dihydro-pyridine-3-carboxylic acid (44 g, 0.20 mmol) in tetrahydrofuran (5 mL) were successively added aniline (20 muL, 0.23 mmol), hydroxybenzotriazole (30 mg, 0.23 mmol), dimethylaminopyridine (27 mg, 0.23 mmol) and EDC (43 mg, 0.23 mmol). The reaction mixture was stirred at room temperature for 16 hours. The solvent was removed in vacuo and the residue was purified by silica gel chromatography eluting with DCM containing 10percent of MeOH to afford the title compound as a white solid (20 mg, 34percent yield). MS (ES+) 291. deltaH (DMSOd6) 7.2 (3H, m), 7.9 (IH, t), 8.5 (IH, d), 8.6 (2H, m), 9.3 (IH, s).

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/65946; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 10177-08-9

With the rapid development of chemical substances, we look forward to future research findings about 10177-08-9.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10177-08-9, name is 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C12H9NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid

PREPARATION 52 2-Chloro-5-phenyl-3-pyridinecarboxylic acid To 191 g (0.98 mole) of phenyl phosphonic dichloride was added 66 g (0.31 mole) of 5-phenyl-2-pyridone-3-carboxylic acid and the reaction mixture heated to 135° C. for 2 hr. After cooling, the reaction mixture was poured into ~1.5 liter of water. To the mixture was added ~1 liter of tetrahydrofuran to partially solubilize the precipitate formed. The temperature was moderated with ice and 1 liter of water was added to complete the precipitation. The crude precipitate was collected and weighed 67 g (0.29 mole, 93percent). A sample was recrystallized from isopropyl alcohol to give white crystals, m.p. 239°-40° C. Analysis: Calculated for C12 H8 NO2 Cl: C, 61.69; H, 3.45; N, 6.00. Found: C, 61.68; H, 3.37; N, 5.97.

With the rapid development of chemical substances, we look forward to future research findings about 10177-08-9.

Reference:
Patent; A. H. Robins Company, Inc.; US4705853; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 10177-08-9

The synthetic route of 10177-08-9 has been constantly updated, and we look forward to future research findings.

Application of 10177-08-9 , The common heterocyclic compound, 10177-08-9, name is 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C12H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 22 5-Phenyl-2(1H)-pyridinone In the manner described in Example 20, a mixture of 12.4 g. of 1,2-dihydro-2-oxo-5-phenyl-3-pyridinecarboxylic acid (prepared as described in Example 15) and 50 ml. of quinoline yields 8.8 g. of the product of the Example as a gray solid, m.p. 173°-177° C.

The synthetic route of 10177-08-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Cyanamid Company; US4209626; (1980); A;; ; Patent; American Cyanamid Company; US4242515; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem