Category: 10177-29-4

Related Products of 10177-29-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10177-29-4, name is 4-Chloronicotinic acid. A new synthetic method of this compound is introduced below.

A mixture of 4-chloronicotinatic acid (7.88 g, 50 mmol) in dichloromethane (100 ml) was added thionyl chloride (12.7 ml, 150 mmol) and DMF (3 drops), and the reaction was refluxed for 2 h. After the reaction was cooled to room temperature, the solvent and thionyl chloride was removed under reduced pressure. Then ethanol (80 ml) and Et3N (13.9 ml, 100 mmol) were added to the residue and the resulting mixture was stirred at room temperature overnight. The solution was diluted with water (80 ml), and extracted with dichloromethane (50 ml 2). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure. The residue was purified by flash column chromatography with petroleum ether/ethyl acetate (10:1) to provide 7.89 g (85%) of 6 as a colorless oil. 1H NMR (300 MHz, CDCl3) d 9.20(s, 1H), 8.82 (d,J 6.0 Hz, 1H), 8.08 (d, J 6.0 Hz, 1H), 4.48 (q, J 7.5 Hz, 2H),1.43 (t, J 7.5 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10177-29-4, its application will become more common.

Reference:
Article; Zou, Qingan; Duan, Hongliang; Ning, Mengmeng; Liu, Jia; Feng, Ying; Zhang, Liming; Zhu, Junjie; Leng, Ying; Shen, Jianhua; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 1 – 15;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10177-29-4, name is 4-Chloronicotinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H4ClNO2

Example 1; 4-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide, hydrochloride salt; A) 4-Chloro-N-(2,4-difluorophenyl)nicotinamide; To a mixture of 4-chloronicotinic acid (Lancaster Synthesis, 0.31 g, 2.0 mmol) and 2,4-difluoroaniline (Aldrich, 0.20 mL, 2.0 mmol) in anhydrous dichloromethane (5 mL) was added bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBroP, Novabiochem, 1.4 g, 3.0 mmol) followed by diisopropylethylamine (1.1 mL, 6.4 mmol). Anhydrous DMF (2 mL) was added to the mixture and the reaction stirred at ambient temperature. After 255 hours, the reaction mixture was partitioned between chloroform and 10% LiCl (aq). The organic layer was washed three times with 10% LiCl (aq), dried over anhydrous MgSO4, then concentrated in vacuo. Purification of the residue by flash column chromatography (SiO2, eluting with 1:1 hexane/EtOAc) afforded the desired compound (0.23 g, 42%). 1H NMR (DMSO-d6) delta 10.58 (s, 1H), 8.78 (s, 1H), 8.66 (d, 1H, J=5.4 Hz), 7.82-7.88 (m, 1H), 7.71 (d, 1H, J=5.4 Hz), 7.37-7.43 (m, 1H), 7.14-7.19 (m, 1H); MS(ESI+) m/z 269 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 10177-29-4.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/78140; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10177-29-4, name is 4-Chloronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 10177-29-4

Intermediate4-(2,5-Dichloro-phenoxy)-nicotinic acidTo a suspension of 10 g (63.47 mmol) 4-chloronicotinic acid (commercially available; CAS RN10177-29-4) and 11.38 g (69.81 mmol) 2,5-dichlorophenol (commercially available CAS RN 583-78-8) in 50 mL dry N,N-dimethylformamide were added 17.55 g (126.94 mmol) potassium carbonate, 1.21 g (6.35 mmol) copper(I) iodide and 1.21 g (19.04 mmol) copper nanopowder. The green suspension was stirred at 120 C. (oil bath temperature) for 3 hours and then cooled down to 80 C. At that temperature, 400 mL water were added, the suspension was stirred at 80 C. for 5 min., filtered over Dicalite speed plus (Acros) and the filter cake washed twice with 50 mL water. The resulting filtrate was extracted three times with ethyl acetate and then the pH was adjusted to 4-5 using 140 mL 1M aqueous hydrochloric acid. The resulting green, turbid solution was treated with ethyl acetate, stirred for 5 min. and filtered. The blue solid that had formed was filtered off and the layers of the filtrate were separated. The aqueous layer was saturated with solid sodium chloride and extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and evaporated. To the resulting solid 200 mL saturated aqueous potassium carbonate solution and 200 mL ethyl acetate were added. The aqueous layer was extracted twice with 200 mL ethyl acetate and the pH was adjusted to 4 using 25% aqueous hydrochloric acid. The resulting suspension was extracted three times with ethyl acetate. The combined organic layers were washed three times with water and once with brine, dried over magnesium sulfate, filtered and evaporated to give the desired compound as a light brown solid (7.29 g, 40%). MS (ESI): m/z=281.8 [M-H]-.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10177-29-4, 4-Chloronicotinic acid.

Reference:
Patent; Bissantz, Caterina; Dehmlow, Henrietta; Erickson, Shawn David; Kim, Kyungjin; Martin, Rainer E.; Sander, Ulrike Obst; Pietranico-Cole, Sherrie Lynn; Richter, Hans; Ulmer, Christoph; US2011/178089; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10177-29-4, name is 4-Chloronicotinic acid, molecular formula is C6H4ClNO2, molecular weight is 157.5545, as common compound, the synthetic route is as follows.Recommanded Product: 4-Chloronicotinic acid

A mixture of amine 4 (1eq.), carboxylic acid (1.2 eq.), diisopropylethylamine (DIEA) (1.5 eq.), and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimidehydrogen chloride (EDC·HCl) (1.2 eq.) in dichloromethane was stirred at room temperature for18 h. The reaction mixture was diluted with dichloromethane and washed withwater and brine. The organic layer was dried over MgSO4 andconcentrated. The crude product was purified by normal phase column chromatography(SP1, Biotage) to yield compound 5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10177-29-4, 4-Chloronicotinic acid, and friends who are interested can also refer to it.

Reference:
Article; Hwang, Jong Yeon; Smithson, David C.; Holbrook, Gloria; Zhu, Fangyi; Connelly, Michele C.; Kaiser, Marcel; Brun, Reto; Kiplin Guy; Bioorganic and Medicinal Chemistry Letters; vol. 23; 14; (2013); p. 4127 – 4131;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 10177-29-4, Name is 4-Chloronicotinic acid, formurla is C6H4ClNO2. In a document, author is Luna-Murillo, Beatriz, introducing its new discovery. Category: pyridine-derivatives.

Catalytic Fast Pyrolysis of Biomass: Catalyst Characterization Reveals the Feed-Dependent Deactivation of a Technical ZSM-5-Based Catalyst

Catalyst deactivation due to coking is a major challenge in the catalytic fast pyrolysis (CFP) of biomass. Here, a multitechnique investigation of a technical Al2O3-bound ZSM-5-based extrudate catalyst, used for the CFP of pine wood and cellulose (at a reactor temperature of 500 degrees C), provided insight into the effects of extrusion, the catalytic pyrolysis process, and catalyst regeneration on the catalyst structure. As a result of a reduction in acidity and surface area due to the coking catalyst, the activity dropped drastically with increasing time-on-stream (TOS), as evidenced by a decrease in aromatics yield. Strikingly, confocal fluorescence microscopy at the single-particle level revealed that vapor components derived from whole biomass or just the cellulose component coke differently. While pine-wood-derived species mainly blocked the external area of the catalyst particle, larger carbon deposits were formed inside the catalyst’s micropores with cellulose-derived species. Pyridine FT-IR and solid-state NMR spectroscopy demonstrated irreversible changes after regeneration, likely due to partial dealumination. Taken together with <30 g kg(-1) aromatics yield on a feed basis, the results show a mismatch between biomass pyrolysis vapors and the technical catalyst used due to a complex interplay of mass transfer limitations and CFP chemistry. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10177-29-4 help many people in the next few years. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

10177-29-4, Name is 4-Chloronicotinic acid, molecular formula is C6H4ClNO2, Category: pyridine-derivatives, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Palacios-Corella, Mario, once mentioned the new application about 10177-29-4.

Hexakis-adducts of [60]fullerene as molecular scaffolds of polynuclear spin-crossover molecules

A family of hexakis-substituted [60]fullerene adducts endowed with the well-known tridentate 2,6-bis(pyrazol-1-yl)pyridine (bpp) ligand for spin-crossover (SCO) systems has been designed and synthesized. It has been experimentally and theoretically demonstrated that these molecular scaffolds are able to form polynuclear SCO complexes in solution. UV-vis and fluorescence spectroscopy studies have allowed monitoring of the formation of up to six Fe(II)-bpp SCO complexes. In addition, DFT calculations have been performed to model the different complexation environments and simulate their electronic properties. The complexes retain SCO properties in the solid state exhibiting both thermal- and photoinduced spin transitions, as confirmed by temperature-dependent magnetic susceptibility and Raman spectroscopy measurements. The synthesis of these complexes demonstrates that [60]fullerene hexakis-adducts are excellent and versatile platforms to develop polynuclear SCO systems in which a fullerene core is surrounded by a SCO molecular shell.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10177-29-4 help many people in the next few years. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 10177-29-4, Name is 4-Chloronicotinic acid, SMILES is ClC1=CC=NC=C1C(=O)O, in an article , author is Chenab, Karim Khanmohammadi, once mentioned of 10177-29-4, Recommanded Product: 10177-29-4.

Cobalt complex dye as a novel sensitizer in dye sensitized solar cells

In this study, cobalt metal complex has been introduced as a novel class of sensitizer for more mechanistic consideration of the photovoltaic conversion efficiency (PCE) of dye sensitized solar cells. UV-vis spectroscopy of dye illustrates maximum absorption at wavelengths of dye in 498 and 650 nm. TiO2 was used as the photoanode of the cell whose x-ray diffraction spectrum indicates that its crystal phase is anatase (101). Surface morphology of photoanode was also investigated by scanning electron microscopy (SEM) and obviously showed similar to 25 nm TiO2 nanoparticles. The cyclic voltammetry (CV) investigation of Pt-coated fluorine doped tin oxide (FTO) as the counter electrode of the cell indicates redox process on this electrode. Photovoltaic measurements of cobalt complex sensitized solar cell show that the short-circuit current density (J(SC)), open-circuit voltage (V-OC), fill factor (FF%) and photovoltaic conversion efficiency (PCE%) are 48.80 mu A.cm(-2), 0.7 V, 44% and 0.09% at the air mass 1.5 (100 mW.cm(-2)) irradiation condition, respectively. The high light harvesting efficiency (LHE) (similar to 61%) and high molar absorption coefficient of the cobalt complex dye (12,500 M-1.cm(-1)) were other optical advantages of the cobalt complex sensitized solar cell. The results indicate the quantum yield of electron injection (phi(ing)) which depends on dye structure as a parameter influences the J(SC). The pyridine rings conformation in donor part of the cobalt complex dye plays a significant role in phi(ing) and subsequently PCE. These findings open a new insight about mechanistic aspects of dye sensitized solar cells efficiency.

Interested yet? Read on for other articles about 10177-29-4, you can contact me at any time and look forward to more communication. Recommanded Product: 10177-29-4.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 10177-29-4, 10177-29-4, Name is 4-Chloronicotinic acid, SMILES is ClC1=CC=NC=C1C(=O)O, belongs to pyridine-derivatives compound. In a document, author is Motloch, Petr, introduce the new discover.

Stimuli-Responsive Self-Sorting Hybrid Hydrogen-Bonded/Metal-Coordinated Cage

The self-assembly of a unique molecular container is reported: a hybrid hydrogen-bonded/metal-coordinated cage where both hydrogen-bonding and metal-coordination form the crucial part of the topology. The hybrid cage was prepared combining hydrogen-bonded rosette motif and palladium(II)/platinum(II) coordination to a pyridine ligand. It was also shown that the hybrid cage could be prepared by integrative self-sorting from simple components. For the first time the genuine dual character of the hybrid cage was manifested as both self-assembling parts responded selectively to different stimuli (such as phosphine and cyanurate), which resulted in the disassembly of the cage.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10177-29-4. Recommanded Product: 10177-29-4.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 10177-29-4, Name is 4-Chloronicotinic acid, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Kuthyala, Sharanya, Recommanded Product: 4-Chloronicotinic acid.

Crystal, Hirshfeld, ADMET, drug-like and anticancer study of some newly synthesized imidazopyridine containing pyrazoline derivatives

To steer the selection of a potent drug, computer models have been fostered as a valid alternative to reduce pharmacokinetics related failure. The present study mainly focuses on the relationship between molecular properties and anticancerous activity of some newly synthesized aza heterocycles. Twelve new imidazo[1,2-a]pyridine incorporated pyrazoline derivatives were synthesized and were well characterized by (HNMR)-H-1, (CNMR)-C-13, LC-MS analysis. X-ray study resolved the structure of 4g, 4i and 4j as monoclinic crystal system. To quantify the electrostatic potential distribution and percentage intermolecular contacts in crystal packing, Hirshfeld surface study was performed. Moreover, virtual screening focused on ADMET and drug-like attributes to identify a promising derivative among the series. The anticancerous activity of the compounds was evaluated against A549 cell line. The study was further validated by subjecting best active compounds to induced hemolysis, which finally confirmed 4j as a potent molecule both in computational and in vitro study. (C) 2019 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 10177-29-4, Recommanded Product: 4-Chloronicotinic acid.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of 4-Chloronicotinic acid, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10177-29-4, Name is 4-Chloronicotinic acid, molecular formula is C6H4ClNO2. In an article, author is Salhi, Lydia,once mentioned of 10177-29-4.

Synthesis of functionalized dihydroimidazo[1,2-A]pyridines and 4-thiazolidinone derivatives from maleimide, as new class of antimicrobial agents

New dihydroimidazo[1,2-a]pyridines and 4-thiazolidinone derivatives have been synthesized by condensation reaction of substituted maleimide with 2,3-diaminopyridine or thiosemicarbazone under neutral or acidic medium in low and good yields. Structures and purity of these new products were confirmed by HRMS, H-1, C-13 NMR, IR spectroscopy and crystal X-ray analysis. Optimization of reaction conditions for the preparation of dihydroimidazo[1,2-a]pyridine was studied by using a Keggin-type heteropolyacid catalyst. All the synthesized compounds were evaluated in vitro for their antibacterial and antifungal activities against six pathogenic bacteria and a strain of yeast. Compounds 4d, 7b, and 7d were more potent than the reference drug, against Candida albicans IPA (200). Compounds 4a, 4b, 7a, and 7b possessed the highest inhibitory effect or bactericidal activity against SARM.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem