Category: 101990-70-9

Adding a certain compound to certain chemical reactions, such as: 101990-70-9, 5-(Chloromethyl)-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 101990-70-9, blongs to pyridine-derivatives compound. Product Details of 101990-70-9

To a stirred solution of compound 2 (400 mg, 1.79 mmol) in DMF (4 mL) at 0 C, was added NaH (90 mg of a 60% dispersion in mineral oil, 2.25 mmol). The mixture was warmed to RT and stirred for 20 mm. The mixture was cooled to 0 C, and a solution of 5-(chloromethyl)-2- methoxypyridine (310 mg, 1.97 mmol) in DMF (1 mL) was added. The mixture was allowed to warm to RT and stirred for a further 16 h. The mixture was partitioned between water (50 mL)and EtOAc (30 mL). The organic layer was separated and the aq. layer re-extracted with additional EtOAc (30 mL). The combined organic layers were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure. The residue was purified (silica gel; eluting with 0-100% EtOAc in hexanes), to afford compound 3 (580 mg, 85%) as a colorless oil. LCMS Mass: 345.0 (M+1).

The synthetic route of 101990-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin, W.; HUTCHINSON, John, Howard; (185 pag.)WO2017/3862; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 101990-70-9, name is 5-(Chloromethyl)-2-methoxypyridine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H8ClNO

A mixture of N-((1S,2S)-2-hydroxycyclohexyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide (Intermediate 13), (120 mg), 5-(chloromethyl)-2-methoxypyridine (69 mg) and cesium carbonate (329 mg) in DMF (3.9 mL) was stirred at rt overnight. A further 20 mg 5-(chloromethyl)-2-methoxypyridine was added and stirred for 2days. A further 100 mg 5-(chloromethyl)-2-methoxypyridine was added and stirred for 24 h. Water (20 mL) was added and the reaction mixture was extracted with EtOAc (3*20 mL). The combined organic layers were washed with brine (20 mL) and dried over MgSO4, filtered and evaporated in vacuo. The residue was purified by column chromatography to give the desired compound (131 mg). LCMS: m/z 395.49 [M+H]+. 1H NMR (400 MHz, CDCl3) ppm 1.15-1.52 ppm (m, 4H) 1.71 (d, J=9.9 Hz, 2H) 2.05 (t, J=9.0 Hz, 2H) 2.50 (s, 3H) 3.16 (br. s., 1H) 3.49 (td, J=9.7, 4.3 Hz, 1H) 3.71-3.84 (m, 1H) 3.83 (s, 3H) 5.43 (s, 2H) 6.62 (d, J=8.6 Hz, 1H) 6.84 (d, J=4.8 Hz, 1H) 7.10 (dd, J=8.6, 2.1 Hz, 1H) 7.79 (d, J=1.8 Hz, 1H) 7.95 (s, 1H) 8.25 (d, J=4.6 Hz, 1H) 9.24 (d, J=7.0 Hz, 1H)

The synthetic route of 101990-70-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Payne, Andrew; Castro Pineiro, Jose Luis; Birch, Louise Michelle; Khan, Afzal; Braunton, Alan James; Kitulagoda, James Edward; Soejima, Motohiro; US2015/94328; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101990-70-9, name is 5-(Chloromethyl)-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H8ClNO

3,7-Dimethyl-1H-purine-2,6(3H,7H)-dione (300 mg, 1.67 mmol) was dissolved in N,N-dimethylformamide (10 mL), and 5-(chloromethyl)-2-methoxypyridine (263 mg, 1.67 mmol), potassium iodide (332 mg, 2.00 mmol) and potassium carbonate (461 mg, 3.34 mmol) were added. The reaction solution was heated to 120C, stirred for 3 hours and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (1:1 petroleum ether / ethyl acetate, Rf = 0.2) to give 1-((6-methoxypyridin-3-yl)methyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione (20.0 mg) with a yield of 4%. 1H NMR: (400 MHz, CDCl3) delta 8.28(s, 1H), 7.78(d, J = 8.0 Hz, 1H), 7.51(s, 1H), 6.67(d, J = 8.0 Hz, 1H), 5.12(s, 2H), 3.99(s, 3H), 3.91(s, 3H), 3.57(s, 3H). MS-ESI calcd. [M + H]+ 302, found 302.

With the rapid development of chemical substances, we look forward to future research findings about 101990-70-9.

Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Lingyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (160 pag.)EP3299371; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 101990-70-9, Adding some certain compound to certain chemical reactions, such as: 101990-70-9, name is 5-(Chloromethyl)-2-methoxypyridine,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101990-70-9.

tert-Butyl (5S)-2-[(6-methoxypyridin-3-yl)methyl]-3-oxo-2,3,5,6,7,8-hexahydro[1,2,4]triazolo[4,3-a]pyridine-5-carboxylate tert-Butyl (5S)-3-oxo-2,3,5,6,7,8-hexahydro[1,2,4]triazolo[4,3-a]pyridine-5-carboxylate (1.33 g, 5.55 mmol) was initially charged in acetonitrile (30 ml). Caesium carbonate (4.52 g, 13.9 mmol), 5-(chloromethyl)-2-methoxypyridine (963 mg, 6.11 mmol) and sodium iodide (5.00 mg, 0.03 mmol) were subsequently added. After stirring for 4 days, the reaction mixture was admixed at room temperature with water and ethyl acetate. The organic phase was removed and the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and filtered, and the filtrate was concentrated. The residue was purified via column chromatography (silica gel, eluent: cyclohexane/ethyl acetate gradient). The product-containing fractions were concentrated under reduced pressure, and 751 mg (37% of theory) of the title compound were obtained. LC-MS (Method 3): Rt=1.56 min; MS (ESIpos): m/z=361 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.385 (16.00), 2.048 (0.54), 2.058 (0.48), 2.525 (0.41), 3.825 (6.81), 4.424 (0.60), 4.791 (2.68), 6.785 (0.78), 6.807 (0.84), 7.574 (0.51), 7.580 (0.52), 7.595 (0.49), 7.602 (0.50), 8.074 (0.67), 8.080 (0.65).

According to the analysis of related databases, 101990-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; BIBER, Nicole; BROCKSCHNIEDER, Damian; GERICKE, Kersten Matthias; KOeLLING, Florian; LUSTIG, Klemens; MEDING, Joerg; MEIER, Heinrich; NEUBAUER, Thomas; SCHAeFER, Martina; TIMMERMANN, Andreas; ZUBOV, Dmitry; TERJUNG, Carsten; LINDNER, Niels; BADOCK, Volker; MOOSMAYER, Dieter; MIYATAKE ONDOZABAL, Hideki; MOORE, Steven; SCHULZ, Alexander; (458 pag.)US2019/160048; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem