Category: 10201-73-7

Adding a certain compound to certain chemical reactions, such as: 10201-73-7, 2-Amino-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H8N2O, blongs to pyridine-derivatives compound. COA of Formula: C6H8N2O

General procedure: To the solution of Acid SM-IX (70 mg, 0.20 mmol, 100 mol-%) in dry DMF (2 ml) under nitrogen atmosphere was added i-hydroxybenzotriazole hydrate (HOBt) (60 mg, 0.45 mmol, 220 mol-%), i-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (EDCI) (86 mg, 0.45 mmol, 220 mol-%) and 3- amino-6-methoxypyridazine (51 mg, 0.41 mmol, 200 mol-%). The reaction mix-ture was stirred at + 50 C for 3.5 hours. Water (3 ml) was added to the reaction mixture. The solid precipitate was filtered and washed several times with water and finally with heptane to yield 56 mg of crude product. Purification was done by flash chromatography. Amount of product compound 3 was 36 mg.1H-NMR (200 MHz, DMSO-d6): 0.98 (5, 3H), 1.20-2.47 (m, 16H),2.60-2.97 (m, 2H), 3.98 (5, 3H), 6.89-7.06 (m, 1H), 7.08-7.21 (m, 2H), 7.25 (d,1H), 8.26 (d, 1H), 10.94 (brs, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10201-73-7, 2-Amino-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; FORENDO PHARMA LTD; HIRVELAe, Leena; HAKOLA, Marjo; LINNANEN, Tero; KOSKIMIES, Pasi; STJERNSCHANTZ, Camilla; (182 pag.)WO2018/224736; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 10201-73-7, 2-Amino-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H8N2O, blongs to pyridine-derivatives compound. COA of Formula: C6H8N2O

General procedure: To the solution of Acid SM-IX (70 mg, 0.20 mmol, 100 mol-%) in dry DMF (2 ml) under nitrogen atmosphere was added i-hydroxybenzotriazole hydrate (HOBt) (60 mg, 0.45 mmol, 220 mol-%), i-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (EDCI) (86 mg, 0.45 mmol, 220 mol-%) and 3- amino-6-methoxypyridazine (51 mg, 0.41 mmol, 200 mol-%). The reaction mix-ture was stirred at + 50 C for 3.5 hours. Water (3 ml) was added to the reaction mixture. The solid precipitate was filtered and washed several times with water and finally with heptane to yield 56 mg of crude product. Purification was done by flash chromatography. Amount of product compound 3 was 36 mg.1H-NMR (200 MHz, DMSO-d6): 0.98 (5, 3H), 1.20-2.47 (m, 16H),2.60-2.97 (m, 2H), 3.98 (5, 3H), 6.89-7.06 (m, 1H), 7.08-7.21 (m, 2H), 7.25 (d,1H), 8.26 (d, 1H), 10.94 (brs, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10201-73-7, 2-Amino-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; FORENDO PHARMA LTD; HIRVELAe, Leena; HAKOLA, Marjo; LINNANEN, Tero; KOSKIMIES, Pasi; STJERNSCHANTZ, Camilla; (182 pag.)WO2018/224736; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 10201-73-7 ,Some common heterocyclic compound, 10201-73-7, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of 2-aminopyridine (0.5 mmol, 1 equiv), p-TSA (0.4 mmol,0.8 equiv), 1-butylpyridinium bromide (1.5 mmol, 3 equiv) in a 50 mL Schlenk tube were added 1,2-dimethoxyethane (2 mL) under air. Then H2O2 (1.2 mmol, 2.4 equiv) was added. The mixture was stirred at 80C for 24 h. And then the mixture was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10201-73-7, 2-Amino-4-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Xu, Tong; Zhou, Wen; Wang, Jing; Li, Xue; Guo, Jun-Wen; Wang, Bin; Tetrahedron Letters; vol. 55; 36; (2014); p. 5058 – 5061;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 10201-73-7, Adding some certain compound to certain chemical reactions, such as: 10201-73-7, name is 2-Amino-4-methoxypyridine,molecular formula is C6H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10201-73-7.

Add in the reaction tube 0.2 mmol of 4-methoxy-2-aminopyridine, 0.2 mmol of beta-nitrostyrene, 10mol% (0.02 mmol) Ce (OTf) 3, 1.5 ml toluene, After the reaction was stirred at 120 C for 10 minutes, the heating and stirring were stopped, the mixture was cooled to room temperature, and the crude product was evaporated under reduced pressure and purified by column chromatography to give the desired product. A mixture of esters (V: V = 5:1), yield 76%. The hydrogen spectrum of the product obtained in this example is shown in Figure 1.The carbon spectrum of the obtained product is shown in Fig. 2.

According to the analysis of related databases, 10201-73-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gannan Normal University; Chen Zhengwang; Ye Min; Zhou Zhonggao; (17 pag.)CN108395399; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 10201-73-7, 2-Amino-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-methoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-methoxypyridine

(41c). A mixture of 2-amino-4-methoxypyridine (2.4 g, 19 mol)and N-bromosuccinimide (3.1 g, 17 mmol) was dissolved in aceticacid (6 mL) and stirred at room temperature for 1 h. The reactionmixture was concentrated under vacuum, basified with saturatedaqueous K2CO3 and extracted with EtOAc. The combined organicswere dried, concentrated under vacuum, and purified by silicagel column chromatography, eluting with 50:1 CH2Cl2:MeOH, togive 41c (1.85 g, 47%). LCMS 203 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10201-73-7, 2-Amino-4-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Article; Cloudsdale, Ian S.; Dickson, John K.; Barta, Thomas E.; Grella, Brian S.; Smith, Emilie D.; Kulp, John L.; Guarnieri, Frank; Kulp, John L.; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 3947 – 3963;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10201-73-7, name is 2-Amino-4-methoxypyridine, the common compound, a new synthetic route is introduced below. name: 2-Amino-4-methoxypyridine

2-Amino-4-methoxypyridine (1.24 g, 10 mmol) was dissolved in 100 mL of acetic acid, After cooling to 0 degrees, A solution of bromine (1.92 g, 12 mmol) in acetic acid (30 mL) was added dropwise. Dropping is completed, The solution is reacted at 30 degrees. 4h, TLC monitoring raw material has been completely reacted, To the reaction solution was added 40 mL of saturated aqueous sodium sulfite solution, 25 degrees stirring reaction 0.5h, Concentrated under reduced pressure, The residue was extracted with ethyl acetate (150 mL ¡Á 3) Dried over anhydrous sodium sulfate, filter, The filtrate was concentrated under reduced pressure, Column chromatography (V (methylene chloride) / V (methanol) = 20/1), Obtained as a light yellow solid (1.45 g, 73%).

The synthetic route of 10201-73-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; Zhen, Changchun; Liu, Bing; Zhang, Weihong; Zhang, Yingjun; Long, Bohua; (59 pag.)CN104513257; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

10201-73-7 , The common heterocyclic compound, 10201-73-7, name is 2-Amino-4-methoxypyridine, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add (1.0 mmol, 0.188 g) to a 50 mL pear-shaped flask3-acetylcoumarin, (1.4 mmol, 0.174 g) of 2-amino-4-methoxypyridine, and (1.0 mmol, 0.254 g) of iodine as a catalyst. The mixture in the pear shaped bottle is at 110 CAfter stirring for 4 h, it was cooled to 70 C and stirred overnight. Then add 5mL of distilled water and 0.6mL of mass fraction of 45%Sodium hydroxide solution (adjust the pH of the solution to 12), the mixture is stirred at 100 C for 1 h, cooled to room temperature, and addedNeutralize with 0.3 mL of 10% by mass of dilute hydrochloric acid until a neutral solution is obtained. Extracted 3 times with dichloromethane (each time25 mL), combined with extract phase, dried over anhydrous sodium sulfate, concentrated to remove solvent, then column chromatography (eluent: V acetic acid)Ethyl ester/V petroleum ether = 1:2) isolated to give a brownish-yellow product 3-(7-methoxy-2-imidazo[1,2a]pyridine)-coumarinCalled HP2) (0.152g, yield 52.2%)

The synthetic route of 10201-73-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Li Yujin; Zhou Zichun; Gao Jianrong; Han Liang; Ye Qing; (18 pag.)CN109943092; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem