Category: 10235-65-1

Related Products of 10235-65-1 ,Some common heterocyclic compound, 10235-65-1, molecular formula is C9H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium Hydride (31 .8 mg, 0.796 mmol) was added to DMF (1 mL), followed by 3,4-dihydro-1 (2H)- isoquinolinone (107 mg, 0.730 mmol). The resulting suspension was stirred at r.t. for 5 min, then 4,6- dichloro-2-(2-pyridinyl)pyrimidine (150 mg, 0.664 mmol) was added and resulting mixture was stirred at r.t. for 45 min.The mixture was partitioned between EtOAc and water then the aqueous layer extracted with DCM three times. The organic layers were combined, filtered throught a phase separator and volatiles removed under reduced pressure to afford 212 mg of a white-brown powder.The crude material was purified by column chromatography, eluting with a 0 to 100% EtOAc in cyclohexane, to give the title compound, 121 mg (54%) as an off white powder.LCMS (Method A) Rt 1 .05 min, MH+=337.0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10235-65-1, 4,6-Dichloro-2-(pyridin-2-yl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David; WO2012/52390; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10235-65-1, name is 4,6-Dichloro-2-(pyridin-2-yl)pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C9H5Cl2N3

Intermediate 134: 4-chloro-2-(2-pyridi vdro-2-naphthalenyloxy)pyrimidine1 ,2,3,4-tetrahydro-2-naphthalenol (164.0 mg, 1 .1 1 mmol) was added to a cold (0C) solution of sodium hydride (48.7 mg, 1 .22 mmol) in A/,A/-dimethylformamide (10 ml_). After 30 min of stirring under nitrogen at 0 C, 4,6-dichloro-2-(2-pyridinyl)pyrimidine (250.0 mg, 1 .1 1 mmol) was added. After 16 hr of stirring at r.t., the reaction mixture was cooled at 0 C and sodium hydride (24.0 mg, 0.60 mmol) was added. After 2 hr of stirring under nitrogen at room temperature, water (50 ml_) was added to the reaction mixture, followed by EtOAc (50 ml_). The aqueous layer was further extracted with EtOAc (50 ml_). The combined organic layers was dried through a hydrophobic frit and concentrated to dryness to give a brown oil. The crude was purified by column chromatography eluting with a gradient from 0-50% of EtOAc-cyclohexane to give the impure product (278.0 mg). 168 mg of the impure product was dissolved in 1 :1 MeOH:DMSO (2 mL) and purified by MDAP (Method E). The solvent was evaporated in vacuo to give the title compound as a yellow oil, 64.2 mg (17%).LCMS (Method A): Rt = 1 .25 min, MH+ 338.1 .

The synthetic route of 10235-65-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David; WO2012/52390; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10235-65-1, name is 4,6-Dichloro-2-(pyridin-2-yl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H5Cl2N3

6-Chloro-2-pyridin-2-yl-pyrimidin-4-ylamine NH4OH (35% solution in water, 2.0 ml, 18.58 mmol) was added to a solution of 4,6-dichloro-2-pyridin-2-yl-pyrimidine (210 mg, 0.93 mmol) in EtOH (2 ml) in a microwave tube and the mixture was heated at 100 C. for 30 min in the microwave. The reaction mixture was concentrated in vacuo and the resulting residue was purified by trituration from iso-propyl alcohol to give the title compound (135 mg, 70%).

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Reference:
Patent; VIFOR (INTERNATIONAL) AG; US2012/202806; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem