Synthetic Route of C6H6ClNO2SOn September 10, 2020 ,《Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists》 was published in Journal of Medicinal Chemistry. The article was written by Cooper, Martin; Llinas, Antonio; Hansen, Peter; Caffrey, Moya; Ray, Asim; Sjoedin, Stina; Shamovsky, Igor; Wada, Hiroki; Jellesmark Jensen, Tina; Sivars, Ulf; Hultin, Leif; Andersson, Ulf; Lundqvist, Sara; Gedda, Karin; Jinton, Lisa; Krutroek, Nina; Lewis, Richard; Jansson, Paul; Gardelli, Cristina. The article contains the following contents:
Muscle atrophy and cachexia are common comorbidities among patients suffering from cancer, chronic obstructive pulmonary disease, and several other chronic diseases. The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of growth hormone secretion and subsequent increase of insulin-like growth factor-1 levels, an important mediator of muscle growth and repair. Ghrelin also acts on inflammation, appetite, and adipogenesis and therefore has been considered a promising therapeutic target for catabolic conditions. We previously reported on the synthesis and properties of an indane based series of ghrelin receptor full agonists which led to a sustained increase of insulin-like growth factor-1 in a dog pharmacodynamic study. Herein we report on the identification of a series of pyrrolidine or piperidine based full agonists and attempted optimization to give compounds with profiles suitable for progression as clin. candidates. In the part of experimental materials, we found many familiar compounds, such as 2-Methylpyridine-4-sulfonyl chloride(cas: 1025509-77-6Synthetic Route of C6H6ClNO2S)
2-Methylpyridine-4-sulfonyl chloride(cas: 1025509-77-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C6H6ClNO2S