Category: 102625-64-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102625-64-9, name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 102625-64-9

At room temperature, 20.2 g of 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methylthio]-1H-benzimidazole are suspended in 100 ml of methyl isobutyl ketone together with 18.0 g of (+)-L-tartaric acid bis-(N,N-dimethylamide) and 13.4 g of zirconium(IV) isopropoxide/isopropanol. The mixture is heated at 40C for one hour, resulting in the formation of a solution which is almost clear. After cooling to room temperature, 4.1 ml of N-ethyldiisopropylamine are added. 11 ml of cumene hydroperoxide are then slowly metered in. Stirring is continued at room temperature until the oxidation has ended (5-10 hours, monitored by TLC). The clear solution is diluted with 100 ml of methyl isobutyl ketone and quenched with 1.8 g of sodium thiosulphate in 140 ml of water and stirred for a further 14 hours. After phase separation, 55 ml of saturated sodium bicarbonate solution and 55 ml of methyl isobutyl ketone are added to the aqueous phase, and the phases are separated. Another 55 ml of saturated sodium bicarbonate solution and 55 ml of methyl isobutyl ketone are added to the aqueous phase, and the phases are separated. The combined methyl isobutyl ketone phases are then washed twice with 55 ml of saturated sodium bicarbonate solution. 150 mi of water are added to the methyl isobutyl ketone phase, and the pH is adjusted to pH = 13 using a 40% by weight strength aqueous solution of sodium hydroxide. After phase separation, the methyl isobutyl ketone phase is extracted with another 50 ml of water at pH = 13. The aqueous phases are combined and, at 40C, subjected to incipient distillation under reduced pressure. At 40-45C, (-)-pantoprazole is precipitated by addition of 10% strength acetic acid to pH = 9.0. Stirring is continued for another 12 hours during which the pH is monitored. The beige crystals are filtered off and washed with 50 ml of water. The title compound is obtained in a yield of about 15 g (73% of theory) and an optical purity of >95%. To increase the purity, (-)-pantoprazole is dissolved in water/aqueous sodium hydroxide solution at pH = 13 and re-precipitated with acetic acid (10%) at pH = 9.0.

With the rapid development of chemical substances, we look forward to future research findings about 102625-64-9.

Reference:
Patent; ALTANA PHARMA AG; WO2004/52882; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Biot, Nicolas, once mentioned the new application about 102625-64-9, Application In Synthesis of 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Substituent-Controlled Tailoring of Chalcogen-Bonded Supramolecular Nanoribbons in the Solid State

In this work, we design and synthesize supramolecular 2,5-substituted chalcogenazolo[5,4-beta]pyridine (CGP) synthons arranging in supramolecular ribbons at the solid state. A careful choice of the combination of substituents at the 2- and 5-positions on the CGP scaffold is outlined to accomplish supramolecular materials by means of multiple hybrid interactions, comprising both chalcogen and hydrogen bonds. Depending on the steric and electronic properties of the substituents, different solid-state arrangements have been achieved. Among the different moieties on the 5-position, an oxazole unit has been incorporated on the Se- and Te-congeners by Pd-catalyzed cross-coupling reaction and a supramolecular ribbon-like organization was consistently obtained at the solid state.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 102625-64-9. The above is the message from the blog manager. Application In Synthesis of 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, belongs to pyridine-derivatives compound. In a document, author is Heinz, Benjamin, introduce the new discover, Name: 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Thiolation of Pyridine-2-sulfonamides using Magnesium Thiolates

The thiolation of pyridine-2-sulfonamides using magnesium thiolates is reported. The ortho -functionalizations of these sulfonamides using TMPMgCl center dot LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by electrophilic quenching produced a range of 3-functionalized pyridine-2-sulfonamides, which were subsequently converted into the corresponding thioethers. Finally, symmetric or asymmetric diorganodisulfides were employed as electrophiles in a one-pot ortho -functionalization-thiolation procedure, leading to pyridine 2,3-disubstituted dithioethers.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 102625-64-9. Name: 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Chaurasia, R., once mentioned the application of 102625-64-9, SDS of cas: 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, molecular weight is 367.37, MDL number is MFCD07368273, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Photophysical, electrochemical and TD-DFT studies of Ni(II) and Mn(II) complexes of N ‘-(2-methylfuran-3-carbonyl)hydrazine carbodithioic acid ethyl ester

Two new complexes [Ni(Hmfchce)(2)(PY)(2)] (1) and [Mn(limfchce)(2)(o-phen)] (2) with [N’-(2-methylfuran-3-carbonyl)hydrazine]-carbodithioic acid ethyl ester (H(2)mfchce) have been synthesized which contain o-phenanthroline (o-phen)/pyridine (py) as coligand. The ligand and its metal complexes have been characterized by elemental analyses. IR, magnetic susceptibility and single crystal X-ray diffraction data. Complexes 1 and 2 crystallize in orthorhombhic system with space group ‘Pbca’ and ‘Pbcn’, respectively. In complex 1, nickel centre is coordinated through one hydrazine nitrogen atom, one carbonyl oxygen of two units of ligand and two pyridine nitrogen atoms. The manganese center in complex 2 is coordinated in a N4O2 core by two uininegative bidentate ligands using hydrazine nitrogen (after loss of proton) and carbonyl oxygen and two nitrogen atoms of o-phen. In both complexes, the metal ion adopts a distorted octahedral geometry. Complexes 1 and 2 are fluorescent materials which exhibit an emission at 291 and 285 nm, respectively upon excitation at 263 and 251 nm. The course of the thermal degradations of complexes 1 and 2 have been investigated by TGA which indicate that metal oxide is formed as the final residue in both complexes. The metal complexes, [Ni(Hmfchce)(2)(Py)(2)] (1) and [Mn(Hmfchce)2(o-phen)] (2) were immobilized on glassy carbon electrodes using Nafion (R) (NO. The modified electrodes have been characterized by cyclic voltammetry in 0.1 M KOH. Complexes 1 and 2 have efficient activity towards electrochemical water oxidation in the 0.1 M KOH. The simulated spectra of the two complexes 1 and 2 are characterized by excited states with ligand-to-ligand charge-transfer (LLCT) and ligand-to-metal charge-transfer (LMCT) character. (C) 2019 Elsevier Ltd. All rights reserved.

If you are interested in 102625-64-9, you can contact me at any time and look forward to more communication. SDS of cas: 102625-64-9.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S. In an article, author is Tafesse, Tadesse Bekele,once mentioned of 102625-64-9, Recommanded Product: 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Synthesis and biological evaluation of 2-(2-methyl-1H-pyrrol-3-yl)-2-oxo-N-(pyridine-3-yl) acetamide derivatives: in vitro alpha-glucosidase inhibition, and kinetic and molecular docking study

One of the therapeutic approaches in the management of type 2 diabetes is delaying the glucose absorption through alpha-glucosidase enzyme inhibition, which can reduce the occurrence of postprandial hyperglycemia. Based on this thought, a series of novel chloro-substituted 2-(2-methyl-1-phenyl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl) acetamide derivatives 5a-i were synthesized and their alpha-glucosidase inhibitory activities were evaluated. All the synthesized compounds have shown moderate to excellent in vitro alpha-glucosidase inhibitory activity with IC50 values in the range of 111-673 mu M) as compared to acarbose, the standard drug (750 +/- 9 mu M). Compound 5e (111 +/- 12 mu M), among the series, was the most potent inhibitor of alpha-glucosidase in a competitive mode of action based on the kinetic study. The molecular docking study of compounds 5e and 5a revealed that they have a lower free binding energy (- 4.27 kcal/mol and – 3.17 kcal/mol, respectively) than acarbose (- 2.47 kcal/mol), which indicates that the target compound binds more easily to the enzyme than acarbose does. The outcomes from the molecular docking studies supported the results obtained from the in vitro assay. In conclusion, the overall results of our study reveal that the synthesized compounds could be a potential candidate in the search for novel alpha-glucosidase inhibitors to manage postprandial hyperglycemia incidence.

If you are hungry for even more, make sure to check my other article about 102625-64-9, Recommanded Product: 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, SMILES is COC1=C(OC)C(CSC2=NC3=CC(OC(F)F)=CC=C3N2)=NC=C1, belongs to pyridine-derivatives compound. In a document, author is Chen, Xiaohua, introduce the new discover, Quality Control of 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Evaluating visually a new apoptosis-induced reagent by a ratiometric two-photon fluorescent pH probe

The level of apoptosis is directly related to the occurrence of cancer and other diseases. Real-time continuous monitoring of apoptotic process of living cells has great potential for early diagnosis of related diseases, as well as evaluation of therapeutic effect and screening of apoptotic drugs. This work proposed a ratiometric two-photon fluorescent probe Lyso-PCE equipped with a dual-function pyridine, as a pH-sensitive and specific lysosome-targeted group. A clear linearity relationship between two-channel fluorescence intensity ratios of Lyso-PCE and pH values was established in both solutions and living cells. Thanks to its ability of quantitative detection of pH, probe Lyso-PCE can detect the dynamic pH changes of lysosomes treated by chloroquine, and also can be used to in situ monitor dexamethasone-induced apoptosis. More importantly, reagent potassium bisperoxo (1,10-phenanthroline) oxovanadate (bpV(phen)) was evaluated and testified as a new apoptotic drug by Lyso-PCE, and the real-time visualization of bpV(phen)-induced apoptosis was realized under two-photon excitation. Our results provide a new and promising strategy for evaluating and screening apoptosis-related drugs.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 102625-64-9 is helpful to your research. Quality Control of 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, SMILES is COC1=C(OC)C(CSC2=NC3=CC(OC(F)F)=CC=C3N2)=NC=C1, in an article , author is Farag, A. A. M., once mentioned of 102625-64-9, COA of Formula: C16H15F2N3O3S.

Synthesis and photoelectrical characterizations of ECPPQT for optoelectronic application

A new derivative of heteroannulated chromeno[2,3-b]pyridine identified as 5-ethyl-7H,9H-chromeno[3 ”,2 ”:5′,6′]pyrido[3′,2′:5,6]pyrano[3,2-c]quinoline-6(5H),7,9-trione (3) (ECPPQT) was easily and efficiently synthesized from DBU catalyzed condensation reaction of 2-aminochromone-3-carboxaldehyde (1) with 6-ethyl-4-hydroxy-2H-pyrano[3,2-c]quinoline-2,5 (6H)-dione (2). Structure of ECPPQT was deduced based on its correct elemental analysis and spectral data (IR, 1H NMR, and mass spectra). The X-ray diffraction patterns of TCVA in powder form show that there are several peaks with different intensities, indicating that the material has a polycrystalline nature. Optical absorption properties of ECPPQT thin films in near ultraviolet, visible and near infrared spectral regions showed characteristic absorption peaks. Optical absorptions were used to determine the characteristic band transitions in the range of 200-1100 nm. Two direct band gaps were calculated and found to be 1.85 and 3.30 eV for the optical and transport energy gaps, respectively. The ECPPQT/p-Si diode performs low photovoltaic characteristics with open circuit voltage of 330 mV, short-circuit current of 37 mu A and fill factor of 33%. The phototransient measurements of the device indicate that the device has a good stability and quick response properties. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

Interested yet? Read on for other articles about 102625-64-9, you can contact me at any time and look forward to more communication. COA of Formula: C16H15F2N3O3S.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Li, Fei-Fei, once mentioned the application of 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, molecular weight is 367.37, MDL number is MFCD07368273, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

H-1 NMR determination of 1,3-dicyclohexylurea, glutaric acid and triethylamine in medical four-arm poly(ethylene glycol)-N-hydroxysuccinimide-glutarate for better quality control

Absorbable vascular sealing medical glue, which belongs to Class III medical devices, is a special new material for preventing the leakage of cerebrospinal fluid. Medical four-arm poly(ethylene glycol)-N-hydroxysuccinimide-glutarate (4-arm-PEG-SG) with a molecular weight of 20 000 is the main component of the absorbable medical glue. According to its quality standard, the quality control of residues 1,3-dicyclohexylurea (DCU), glutaric acid (GA) and triethylamine (TEA) is required. A rapid analytical method of quantitative H-1 nuclear magnetic resonance (H-1 NMR) for the determination of residues DCU, GA and TEA in medical 4-arm-PEG-SG was established in the present study. The peaks at delta 1.56 (4H, m), delta 2.71 (4H, t, J = 6.7 Hz), and delta 2.42 (6H, q, J = 7.2 Hz) were selected for quantifying DCU, GA and TEA, respectively, with deuterated pyridine as the solvent and tetramethylsilane as the internal standard. The H-1 NMR assay was validated by several experimental parameters including specificity, linearity, accuracy, precision, robustness, limit of detection (LOD), limit of quantification (LOQ) and stability. The average recoveries obtained were in the range of 99.48-102.02% for all three residues. Compared with the HPLC and GC approaches, the proposed H-1 NMR method proved to be a powerful tool for quantification due to its unique advantages of simplicity, rapidity and high robustness, especially not requiring standard compounds for calibration curve preparation.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 102625-64-9, Recommanded Product: 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Kumari, Shweta, once mentioned the new application about 102625-64-9, HPLC of Formula: C16H15F2N3O3S.

Graphene oxide-TiO2 composite: an efficient heterogeneous catalyst for the green synthesis of pyrazoles and pyridines (vol 40, pg 5053, 2016)

Correction for ‘Graphene oxide-TiO2 composite: an efficient heterogeneous catalyst for the green synthesis of pyrazoles and pyridines’ by Shweta Kumari et al., New J. Chem., 2016, 40, 5053-5060.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 102625-64-9. The above is the message from the blog manager. HPLC of Formula: C16H15F2N3O3S.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, 102625-64-9, Name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, belongs to pyridine-derivatives compound. In a document, author is Hu, Lingjuan, introduce the new discover.

The in situ grafting from approach for the synthesis of polymer brushes on upconversion nanoparticles via NIR-mediated RAFT polymerization

We report the first example of in situ polymer brush growth on the surface of upconversion nanoparticles (UCNPs) in a one-pot near-infrared (NIR) light mediated reversible addition-fragmentation chain transfer (RAFT) polymerization. In the process of polymerization, the surface growth of polymer brushes was realized through an efficient in situ ligand exchange between a photo-activated chain transfer agent (CTA) and the ligand groups on the surface of UCNPs. BF4- was found to be the most efficient ligand in comparison with oleic acid and pyridine. The 980 nm NIR-mediated RAFT polymerization exhibits good temporal control with a low dispersity (M-w/M-n < 1.30), and the thickness of the polymer brushes can be easily adjusted by changing the polymer molecular weight and light exposure time. Moreover, the growth of polymer brushes can proceed even if there is a barrier (e.g. chicken skin) outside the reactor due to the excellent penetration ability of the NIR light. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 102625-64-9. Application In Synthesis of 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem