Electric Literature of 1027785-19-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1027785-19-8 as follows.
B) To a suspension of compound A of Example 5 (1.9 g, 9.36 mmol) in toluene (20 mL) was added activated Mntheta2 (2.2 g, 25.6 mmol) and the mixture was heated to 80 0C with vigorous stirring. After 2 h, the mixture was cooled to RT and filtered. The filtrate was concentrated in vacuo to obtain 6-amino-5- bromonicotinaldehyde as a solid (1.8 g, 96%). LC/MS; (M+H)+ = 203, 201 (1: 1 ratio). 1H NMR (CD3OD, 300 MHz) delta 9.59 (s, IH), 8.34 (s, IH), 8.03 (s, IH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1027785-19-8, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/60907; (2008); A2;,
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