Category: 1028-86-0

Flouzat, Christine; Guillaumet, Gerald published an article on January 31 ,1990. The article was titled 《A new convenient synthesis of 2-aryl- and 2-heteroaryloxazolo[5,4-b]pyridinesã€? and you may find the article in Synthesis.COA of Formula: C12H8ClN3O3 The information in the text is summarized as follows:

Aminochloropyridines I (R = H, Cl) were treated with R1COCl (R1 = Ph, 2-FC6H4, 4-ClC6H4, 2-ClC6H4, 4-MeOC6H4, 2-O2NC6H4, 4-MeC6H4, 4-NCC6H4, 2-furyl, 2-thienyl) to give 95-98% amides II. Heating II in the presence of trimethylsilyl polyphosphate ester with or without a solvent (1,2-dichlorobenzene) gave 75-98% oxazolopyridines III. In the experiment, the researchers used many compounds, for example, N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0COA of Formula: C12H8ClN3O3)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C12H8ClN3O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina published an article in Tetrahedron. The title of the article was 《Palladium-mediated approach to dibenzo[b,e][1,4]diazepines and benzopyrido-analogues. An efficient synthesis of tarpaneã€?Recommanded Product: 1028-86-0 The author mentioned the following in the article:

An original synthetic route toward dibenzo[b,e][1,4]diazepin-11-ones, e.g., I, and analogs pyridobenzodiazepinones has been developed. The method relied upon an intramol. amination process between an (hetero)aryl halide and the appropriate aniline moiety. In the experimental materials used by the author, we found N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Recommanded Product: 1028-86-0)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blockingâ€?substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 1028-86-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte published their research in Journal of Medicinal Chemistry on August 12 ,2004. The article was titled 《Fluorescent Pirenzepine Derivatives as Potential Bitopic Ligands of the Human M1 Muscarinic Receptor》.Application of 1028-86-0 The article contains the following contents:

Following a recent description of fluorescence resonance energy transfer between enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and Bodipy-labeled pirenzepine, the authors synthesized seven fluorescent derivatives of this antagonist in order to further characterize ligand-receptor interactions. These compounds carry Bodipy [558/568], Rhodamine Red-X [560/580], or Fluorolink Cy3 [550/570] fluorophores connected to pirenzepine through various linkers. All mols. reversibly bind with high affinity to M1 receptors (radioligand and energy transfer binding experiments) provided that the linker contains more than six atoms. The energy transfer efficiency exhibits modest variations among ligands, indicating that the distance separating EGFP from the fluorophores remains almost constant This also supports the notion that the fluorophores may bind to the receptor protein. Kinetic analyses reveal that the dissociation of two Bodipy derivatives (10 or 12 atom long linkers) is sensitive to the presence of the allosteric modulator brucine, while that of all other mols. (15-24 atom long linkers) is not. The data favor the idea that these analogs might interact with both the acetylcholine and the brucine binding domains. The experimental part of the paper was very detailed, including the reaction process of N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Application of 1028-86-0)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 1028-86-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cellier, Marie; Gignoux, Amandine; James, Arthur L.; Orenga, Sylvain; Perry, John D.; Robinson, Shaun N.; Stanforth, Stephen P.; Turnbull, Graeme published their research in Bioorganic & Medicinal Chemistry Letters on December 15 ,2015. The article was titled 《2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms》.Name: N-(2-Chloropyridin-3-yl)-2-nitrobenzamide The article contains the following contents:

A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clin. important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-neg. bacteria and also with two of a panel of 8 Gram-pos. bacteria. In the experimental materials used by the author, we found N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Name: N-(2-Chloropyridin-3-yl)-2-nitrobenzamide)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: N-(2-Chloropyridin-3-yl)-2-nitrobenzamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liegeois, Jean Francois F.; Bruhwyler, Jacques; Damas, Jacques; Nguyen, Thuy Phuong; Chleide, Eric M. G.; Mercier, Michel G. A.; Rogister, Francoise A.; Delarge, Jacques E. published an article in Journal of Medicinal Chemistry. The title of the article was 《New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study》.Synthetic Route of C12H8ClN3O3 The author mentioned the following in the article:

The discovery of a new, safe, atypical antipsychotic remains an important challenge. To achieve this goal, a series of N-methylpiperazinopyrido[2,3-b][1,4]- and -[1,5]- and -pyrido[4,3-b][1,4]- and -[1,5]-benzodiazepines I (A = Y = N, B = CH, R1 = H, 8-, 9-Cl, 8-F, 8-Me, R2 = H, 3-Me, R3 = H, Me, CHO, X = C-NMP, NMP = N-methylpiperazino; A = X = N, B = CH, R1 = R2 = H, R3 = H, CHO, Y = C-NMP; A = CH, B = Y = N, R1 = R2 = R3 = H, X = C-NMP; A = CH, B = X = N, R1 = R2 = H, R3 = H, CHO) were synthesized. Thus, (chloropyridinyl)aminobenzamides II (R1 = H, 8-, 9-Cl, 8-F, 8-Me, R2 = H, Me) cyclized and were condensed with N-methylpiperazine to give I. The dopaminergic (D1, D2), serotonergic (5-HT2), and cholinergic (M) affinities, frequently remarked in the action mechanisms of antipsychotic drugs, were determined using their resp. in vitro receptor binding assays. All affinities were reduced for each compound Optimal substituents were found to be in the 2- or 8-position for the retention of affinities, while substitution at the 5-position by acyl or alkyl groups dramatically diminished binding affinities. Pyridobenzodiazepine derivatives, such as clozapine, were found to be inactive or only weakly effective against apomorphine-mediated stereotypes in rats. In an original and complex behavioral model developed in dogs and successfully used to differentiate distinct classes of psychotropic drugs and to discriminate between typical and atypical neuroleptic drugs, I (A = N, B = CH, R1 = 8-Cl, 8-Me, R2 = R3 = H, X = C-NMP, Y = N; A = N, B = CH, R1 = R2 = R3 = H, X = N, Y = C-NMP) showed most of the behavioral characteristics previously described for neuroleptics. Their neurochem. profiles, particularly their 5-HT2/D2 pKi ratios, were compatible with an atypical antipsychotic effect. In the experiment, the researchers used N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Synthetic Route of C12H8ClN3O3)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C12H8ClN3O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem