Category: 103-74-2

The author of 《Electrochemical Deoxygenation of N-Heteroaromatic N-Oxides》 were Xu, P.; Xu, H.-C.. And the article was published in Synlett in 2019. Computed Properties of C7H9NO The author mentioned the following in the article:

An electrochem. method for the deoxygenation of N-heteroaromatic N-oxide, e.g., I to give the corresponding N-heteroaromatics, e.g., II has been developed. Several classes of N-heterocycles such as pyridine, quinoline, isoquinoline, and phenanthridine are tolerated. The electrochem. reactions proceed efficiently in aqueous solution without the need for transition-metal catalysts and waste-generating reducing reagents. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,He, Peipei; Chen, Bo; Huang, Liang; Liu, Xixi; Qin, Jingzhong; Zhang, Zehui; Dai, Wen published an article in Chem. The title of the article was 《Heterogeneous manganese-oxide-catalyzed successive cleavage and functionalization of alcohols to access amides and nitriles》.Recommanded Product: 103-74-2 The author mentioned the following in the article:

Herein, a novel and efficient protocol that enables the direct synthesis of amides via heterogeneous manganese-oxide-catalyzed successive cleavage and amidation of C-C bonds in alcs was reported. A wide range of primary and secondary alcs., 1,2-diols, and even β-O-4 and β-1 lignin model compounds can undergo C-C bond cleavage smoothly to deliver one- or multiple-carbon shorter amides. Moreover, a slight modification of reaction conditions allows for the cleavage and cyanation of alcs. to access sterically hindered nitriles. Detailed characterizations and d. functional theory (DFT) calculations indicate that high sp. surface area, abundant oxygen vacancies, and moderate acid sites contribute to the high catalytic performance of the manganese oxides. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iron-Catalyzed Direct Cross-Coupling of Ethers and Thioether with Alcohols for the Synthesis of Mixed Acetals》 was written by Han, Wei; Cheng, Lu; Zhao, Hongyuan. COA of Formula: C7H9NO And the article was included in Synlett in 2020. The article conveys some information:

An iron-catalyzed direct O-alkylation of alcs. via α-C(sp 3)-H activation of ethers and a thioether was established that tolerates cyclic and acyclic ethers and alcs. containing aromatic N-heterocyclic moieties, providing an efficient and green method for the synthesis of mixed acetals with good to excellent yields. The robustness of this protocol is demonstrated by the late-stage oxidation of a structurally complex natural product. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Molecules included an article by Hong, Ki Bum; Kim, Darong; Kim, Bo-Kyung; Woo, Seo Yeon; Lee, Ji Hoon; Han, Seung-Hee; Bae, Gyu-Un; Kang, Soosung. Safety of 2-(2-Hydroxyethyl)pyridine. The article was titled 《CF3-substituted mollugin 2-(4-morpholinyl)-ethyl ester as a potential anti-inflammatory agent with improved aqueous solubility and metabolic stability》. The information in the text is summarized as follows:

Although mollugin, the main ingredient of the oriental medicinal herb Rubia cordifolia, has considerable anti-inflammatory effects, it has poor aqueous solubility as well as poor metabolic and plasma stability. To overcome these shortfalls, various mollugin derivatives have been synthesized and evaluated for their ability to inhibit U937 monocyte cell adhesion to HT-29 colonic epithelial cells in TNF-α or IL-6-induced models of colon inflammation. The 2-(4-morpholinyl)-Et ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-α and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H9NOIn 2022 ,《Continuous Flow Microreactor Promoted the Catalytic N -Oxidation Reaction of Pyridine Derivatives》 appeared in Synthesis. The author of the article were Chen, Siyuan; Yang, Shanxiu; Wang, Hao; Niu, Yanning; Zhang, Zhang; Qian, Bo. The article conveys some information:

A simple continuous flow microreactor was successfully constructed for the N-oxidation of pyridine. The continuous flow microreactor used titanium silicalite (TS-1) in a packed-bed microreactor and H2O2 (in methanol as solvent) as the catalytic oxidation system for the formation of various pyridine N-oxides in up to 99% yields. This process is a safer, greener, and more highly efficiency process than using a batch reactor. The device was used for over 800 h of continuous operation with the catalyst maintaining great activity thus providing great potential for large-scale production The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Zhou, Pei; Wang, Lei; Wu, Guangyu; Zhou, Yuting; Hegazy, Mohammad; Huang, Xin published 《In Situ Generation of Core-Shell Protein-Based Microcapsules with Regulated Ion Absorbance Capacity》.ChemistrySelect published the findings.COA of Formula: C7H9NO The information in the text is summarized as follows:

In this study, we presented a way to generate organic/protein hybrid core-shell micro-compartment structure by in situ generating poly(o-phenylenediamine) (POPD) nanoparticles inside a robust and flexible protein-based shell. Both the size and number of the generated POPD core inside the protein microcapsules could be well varied by using different oxidants including, H2O2, tert-Bu hydroperoxide (TBHP) and glucose oxidase (GO)/ glucose (Glu). Significantly, via operating the membrane permeability by either the cleavage of the conjugated polymer or addnl. formation of tannic acid/Fe3+ complex outer shell, the adsorption capacity towards Cu2+ of the constructed multiple cores in single shell model could be well modulated. In general, our studies contribute to the establishment of an improved model with its potential applications in catalysis system, biotechnol. and biomedicine. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aboonajmi, Jasem; Panahi, Farhad; Sharghi, Hashem published their research in ACS Omega in 2021. The article was titled 《One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles》.Reference of 2-(2-Hydroxyethyl)pyridine The article contains the following contents:

The multicomponent coupling reaction of catechol, ammonium acetate, and benzyl alc./benzyl Me ether in the presence of a Fe(III) catalyst precursor afforded benzoxazole derivatives in good to excellent yields. The notable features of this protocol are abundant availability of the catalyst system, large-scale synthesis, high diversity, and high yields of products.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wang, Shi-yin; Chen, Guo; Chen, Ji-feng; Wang, Jin; Deng, Shao-hui; Cheng, Du published an article in RSC Advances. The title of the article was 《Glutathione-depleting polymer delivering chlorin e6 for enhancing photodynamic therapy》.Reference of 2-(2-Hydroxyethyl)pyridine The author mentioned the following in the article:

The therapeutic effect of photodynamic therapy (PDT) is highly dependent on the intracellular production of reactive oxygen species (ROS). However, the ROS generated by photosensitizers can be consumed by the highly concentrated glutathione (GSH) in tumor cells, severely impairing the therapeutic effect of PDT. Herein, we synthesized a GSH-scavenging copolymer to deliver photosensitizer chlorin e6 (Ce6). The pyridyl disulfide groups, which have faster reactivity with the thiol groups of GSH than other disulfide groups, were grafted onto a hydrophobic block to encapsulate the Ce6. Under NIR irradiation, the Ce6 generated ROS to kill tumor cells, and the pyridyl disulfide groups depleted the GSH to prevent ROS consumption, which synergistically enhanced the therapeutic effect of PDT. In vitro and in vivo experiments confirmed the combinatory antitumor effect of Ce6-induced ROS generation and the pyridyl disulfide group-induced GSH depletion. Therefore, the pyridyl disulfide group-grafted amphiphilic copolymer provides a more efficient strategy for enhancing PDT and has promising potential for clin. application. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Su, Fangyao; Zhao, Qianrui; Wang, Mengzhuo; Zhao, Mingzhang; Ren, Yihe; Zhu, Binghan; Chen, Haoran; Lai, Miao; Zhao, Mingqin published an article in ChemistrySelect. The title of the article was 《A Convenient Esterification of N-Heteroarene Methanols via C-CN Bond Cleavage of Benzoyl Cyanides as Acylating Sources》.Formula: C7H9NO The author mentioned the following in the article:

An efficient and straightforward methodol. for the esterification of various N-heteroarene methanols using benzoyl cyanides as acylating sources through a simply mixing conditions has been reported. The acyl groups were in-situ generated via chemoselective C-CN bond cleavage to give the N-heteroarenemethyl esters. This process features in readily accessible starting materials and offers an easy operational procedure, and broad substrate scope with excellent selectivity. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H9NOIn 2018 ,《Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols》 appeared in Organic Letters. The author of the article were Zhang, Hong; Ruiz-Castillo, Paula; Buchwald, Stephen L.. The article conveys some information:

Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcs. For activated substrates, such as electron-deficient aryl halides, the com. available ligand I [R = R’ = Bu-t] promotes efficient coupling for a variety of alc. nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand I [R = adamantyl, R’ = cyclohexyl] was developed to improve these challenging C-O bond-forming reactions. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem