Category: 103-74-2

Related Products of 103-74-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.103-74-2, name is 2-(2-Hydroxyethyl)pyridine, molecular formula is C7H9NO, molecular weight is 123.1525, as common compound, the synthetic route is as follows.

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (300mg, 1.019mmol) obtained in Preparation Example 2 was dissolved in THFlbenzene (30mL/10mL). 2-Pyridine ethanol (308mg, 2.039mmol) and triphenyl phosphine (534mg, 2.039mmol) were added thereto, and cooled to 0C. Subsequently, diisopropyl azodicarboxilate (412mg, 2.039mmol) was slowly dropped thereto and stirred for lhr at RT. The resulting mixture was washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgS04 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 388g of 6-[2-(pyridine-2-yl)-ethoxy]-l-oxo-3-phenyl-lH-indene-2-carboxylic acid ethyl ester (yield: 89%) as a red solid. Then, 1-oxo-3-phenyl-6-(2-pyridine-2-yl-ethoxy)-lH-indene-2-carboxylic acid ethyl ester (60mg, 0.15mmol) thus obtained was dissolved in THF and phenylmagnesium chloride (0.15mL, 0.3mmol) was added thereto. The mixture was stirred for 5 minutes at RT, washed with sodium chloride solution and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgS04 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 44mg of the titled compound (yield: 61%)

Statistics shows that 103-74-2 is playing an increasingly important role. we look forward to future research findings about 2-(2-Hydroxyethyl)pyridine.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JEIL PHARM. CO., LTD.; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; CJ CORP.; WO2005/100297; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 103-74-2, name is 2-(2-Hydroxyethyl)pyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Aqueous HBr (2.5 L) was charged into a clean and dry round bottom flask followed by compound (9) (250 g, 2.03 mol) and heated to 120 C with azeotropical removal of water (-24 h). The residual water was removed by co-distillation with toluene (2 x 2 L), thesolid was stined in MTBE: IPA (1:1) for 1 h and filtered, washed with MTBE (200 ml) and dried in vacuum, yielding 360 g (66%) of light pink solid (compound (10)).

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Reference:
Patent; MAPI PHARMA LTD.; MAROM, Ehud; RUBNOV, Shai; (44 pag.)WO2016/132343; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem