Category: 103-74-2

In 2019,Organic Letters included an article by Bettoni, Leo; Gaillard, Sylvain; Renaud, Jean-Luc. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Iron-Catalyzed β-Alkylation of Alcohols》. The information in the text is summarized as follows:

β-Branched alkylated alcs. have been prepared in good yields using a double-hydrogen auto-transfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcs. and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcs. (2-arylethanol and either methanol or benzyl alc.) served as hydrogen donors in this cascade process.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Iron-Catalyzed Borrowing Hydrogen β-C(sp3)-Methylation of Alcohols》 were Polidano, Kurt; Williams, Jonathan M. J.; Morrill, Louis C.. And the article was published in ACS Catalysis in 2019. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine The author mentioned the following in the article:

Herein we report the iron-catalyzed β-C(sp3)-methylation of primary alcs. using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield). In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A unique nickel-base nitrogen-oxygen bidentate ligand catalyst for carbonylation of acetylene to acrylic acid》 were Cui, Long; Yang, Xiangui; Zeng, Yi; Chen, Yuntang; Wang, Gongying. And the article was published in Molecular Catalysis in 2019. Electric Literature of C7H9NO The author mentioned the following in the article:

A nickel-base nitrogen-oxygen bidentate ligand catalyst was prepared in-situ via the complexation method. Our results show that the ligand with nickel can form a chelate catalyst possessing a ring structure, which exhibits good catalytic performance in the carbonylation reaction of acetylene to acrylic acid (AA). Furthermore, we discovered that, under our optimized conditions, when 8-hydroxyquinoline (HQ) is used as the ligand [c(Ni(OAc)2·4H2O) = 15 X 10-6 mol L-1, n(HQ):n(Ni(OAc)2·4H2O) = 1:1, V(H2O) = 7 mL], 70.1% conversion of acetylene and 92.4% the selectivity of AA is achieved at 200 °C with 8.0 MPa pressure for 30 min. Compared to traditional acetylene carbonylation catalysts and nickel-base phosphine ligand homogeneous complex catalysts, our catalytic system has unique advantages, including no copper, no halogen and no carbon deposition generated during the reaction process. It displays high selectivity and no corrosion of equipment, suggesting that this catalytic system possesses future industrial applications. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Electric Literature of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ynamide-Mediated Thionoester and Dithioester Synthesesã€?was written by Yao, Chaochao; Yang, Jinhua; Lu, Xiaobiao; Zhang, Shuyu; Zhao, Junfeng. Reference of 2-(2-Hydroxyethyl)pyridineThis research focused onynamide mediated thionoester dithioester synthesis. The article conveys some information:

A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish α-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, resp. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Nanjo, Takeshi; Kato, Natsuki; Takemoto, Yoshiji published 《Oxidative Decarboxylation Enables Chemoselective, Racemization-Free Esterification: Coupling of α-Ketoacids and Alcohols Mediated by Hypervalent Iodine(III)ã€?Organic Letters published the findings.Reference of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

An α-ketoacid could be converted into a reactive acylating agent by treatment with hypervalent iodine(III) species, and in so doing, a novel decarboxylative acylation of alcs. is discovered that affords a variety of esters in excellent yields. The esterification has been applied to a sterol bearing a free carboxylic acid and shows unique chemoselectivity. The procedure is racemization-free and operates under mild conditions.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cmâˆ?1 (ν19b mode) does not overlap with any of the other bands.Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Ibrahim, Adel Ehab; El Deeb, Sami; Abdellatef, Hisham Ezzat; Hendawy, Hassan A. M.; El-Abassy, Omar M.; Ibrahim, Hany published an article in Separations. The title of the article was 《Eco-Friendly and Sensitive HPLC and TLC Methods Validated for the Determination of Betahistine in the Presence of Its Process-Related Impurityã€?Name: 2-(2-Hydroxyethyl)pyridine The author mentioned the following in the article:

Reducing the amounts consumed of organic solvents while keeping good chromatog. performance has been a significant step towards the greening of anal. methodologies. When sodium dodecyl sulfate (SDS) and Brij-35 surfactants are combined in a mobile phase, they can be used as a green alternative to organic modifiers. Surfactants have numerous advantages, including low cost and toxicity, safe environmental disposal, and unique selectivity, in addition to high solubilization capabilities. In this research, two highly selective chromatog. methods were adopted for the determination of betahistine (BHS) in the presence of its pharmacopeial impurity 2-(2-hydroxyethyl)pyridine (HEP). A solvent-free HPLC method was validated, in which the mixture was separated using a C18 column (3.5μm, 75.0 x 4.6 mm) and a mobile phase composed of 0.01 M Brij-35, 0.12 M SDS, and 0.02 M disodium hydrogen phosphate adjusted to a pH of 5.5 using phosphoric acid. The flow rate was 1.5 mL min-1 and the resolved peaks were detected at 260 nm. Another HPTLC-densitometric method was validated using HPTLC aluminum plates coated with silica gel 60 F254 as the stationary phase and a developing system consisting of methylene chloride/methanol/ethyl acetate/ammonia (at a ratio of 5:2:2:0.2 by volume); the separated bands were scanned at 260 nm.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2021 ,《Titanium Complexes with Functional Alkoxido Ligands for Selective Ethylene Dimerization – A High Throughput Experimentation Approachã€?appeared in ChemCatChem. The author of the article were Grasset, Fabien L.; Welter, Richard; Braunstein, Pierre; Olivier-Bourbigou, Helene; Magna, Lionel. The article conveys some information:

New titanium complexes of general formula [Ti(OR)2(OiPr)2], containing functionalized alkoxido ligands, were developed for the selective catalytic dimerization of ethylene to 1-butene using a combined High Throughput Screening (HTS) / Design of Experiment (DoE) approach. First, a library of 19 ligands was elaborated and a primary screening spotted the phosphorus-functionalized alkoxido ligands as most promising. A second, more focused library containing 8 alkoxidophosphine ligands was then developed. A longer linear spacer between the alkoxido and the phosphorus functions, as in [Ti(19)2(OiPr)2], was found beneficial for this catalytic reaction. After identification of the best co-catalyst (AlEt3) and co-ligand (OBu), final optimization of the reaction conditions was performed using a design of experiments (DoE) approach. The complex [Ti(19)2(OBu)2] was shown to selectively dimerize ethylene in 1-butene (C4(α)=93% (99+%)) at 30 bar C2H4 and 55° with AlEt3 as co-catalyst, resulting in very high activity and selectivity for a mol. titanium catalyst (13000 g gTi-1 h-1, 93% 1-butene). In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mohammad, Akbar; Ansari, Shagufi Naz; Chaudhary, Archana; Ahmad, Khursheed; Rajak, Richa; Tauqeer, Mohd.; Mobin, Shaikh M. published 《Enthralling Adsorption of Different Dye and Metal Contaminants from Aqueous Systems by Cobalt/Cobalt Oxide Nanocomposites Derived from Single-Source Molecular Precursorsã€?ChemistrySelect published the findings.SDS of cas: 103-74-2 The information in the text is summarized as follows:

The cobalt/cobalt oxide nanocomposites (Co/CoO NCs), NC-1 and NC-2 were synthesized from our recently reported single-source mol. precursors (SSMPs) [Co(hep-H)(H2O)4]SO4, (1) and [Co(hep-H)2(H2O)2](NO3)2, (2), [hep-H= 2-(2-hydroxylethyl) pyridine], resp., via wet-chem. reduction method. Our purpose was to study the effect of different counter anions (i. e. SO42- and NO3-) of precursors on the surface properties of synthesized materials. Both the nanocomposites were characterized by Powder X-ray diffraction (PXRD), SEM (SEM), energy-dispersive X-ray anal. (EDAX), transmission electron microscopy (TEM), Fourier transform IR (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) anal. Two distinct morphol. as well as surface features have been obtained using 1 and 2 viz. variable spheres (NC-1) with low surface area and flakes (NC-2) with high surface area. The adsorption behavior of these nanocomposites on industrial dyes and heavy metals showed excellent dye adsorption (99.6% to 97.2%) and good to moderate metal adsorption efficiency of NC-1. The NC-1 could be recycled up to five times for dyes and three times for metals, advocating its practical applications in industry. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mohammad, Akbar; Ansari, Shagufi Naz; Chaudhary, Archana; Ahmad, Khursheed; Rajak, Richa; Tauqeer, Mohd.; Mobin, Shaikh M. published 《Enthralling Adsorption of Different Dye and Metal Contaminants from Aqueous Systems by Cobalt/Cobalt Oxide Nanocomposites Derived from Single-Source Molecular Precursors》.ChemistrySelect published the findings.SDS of cas: 103-74-2 The information in the text is summarized as follows:

The cobalt/cobalt oxide nanocomposites (Co/CoO NCs), NC-1 and NC-2 were synthesized from our recently reported single-source mol. precursors (SSMPs) [Co(hep-H)(H2O)4]SO4, (1) and [Co(hep-H)2(H2O)2](NO3)2, (2), [hep-H= 2-(2-hydroxylethyl) pyridine], resp., via wet-chem. reduction method. Our purpose was to study the effect of different counter anions (i. e. SO42- and NO3-) of precursors on the surface properties of synthesized materials. Both the nanocomposites were characterized by Powder X-ray diffraction (PXRD), SEM (SEM), energy-dispersive X-ray anal. (EDAX), transmission electron microscopy (TEM), Fourier transform IR (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) anal. Two distinct morphol. as well as surface features have been obtained using 1 and 2 viz. variable spheres (NC-1) with low surface area and flakes (NC-2) with high surface area. The adsorption behavior of these nanocomposites on industrial dyes and heavy metals showed excellent dye adsorption (99.6% to 97.2%) and good to moderate metal adsorption efficiency of NC-1. The NC-1 could be recycled up to five times for dyes and three times for metals, advocating its practical applications in industry. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iron-catalyzed remote functionalization of inert C(sp3)-H bonds of alkenes via 1,n-hydrogen-atom-transfer by C-centered radical relay》 was published in Chemical Science in 2020. These research results belong to Bian, Kang-Jie; Li, Yan; Zhang, Kai-Fan; He, Yan; Wu, Tian-Rui; Wang, Cheng-Yu; Wang, Xi-Sheng. Recommanded Product: 2-(2-Hydroxyethyl)pyridine The article mentions the following:

Enabled by 1,n (n = 5, 6)-hydrogen atom transfer (HAT), a most prevalent moiety, alkene, as the precursor to an sp3 C-centered radical to promote selective cleavage of inert C(sp3)-H bonds for the generation of azidotrifluoromethylated mols. I [R1 = Me, n-Bu, Ph, etc.; R2 = H, Me, Et, n-octyl; R1R2 = (CH2)3, (CH2)4, (CH2)2O(CH2)2, etc.; X = C(CO2Et)2, C(CH2OBz)2, NTs] was used. Mild conditions, broad scope and excellent regioselective control (>20 : 1) were observed in the reactions. Deuterium labeling studies disclosed the kinetic characteristics of the transformations and verify a direct 1,n-HAT pathway. The key to this C-centered radical relay was that iron played a dual role as a radical initiator and terminator to incorporate the azide functionality through radical oxidation via azido-ligand-transfer. The methods and the later derivatization promised expeditious synthesis of CF3-containing organic azides, γ-lactam and triazoles that were widely used in designing new fluorescent tags and functional materials. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem