Category: 103-74-2

Ma, Cui-Cui; Zhu, Xing-Xing; Liu, Li; Dai, Jian-Jun; Xu, Jun; Xu, Hua-Jian published their research in Tetrahedron Letters in 2021. The article was titled 《Synthesis of polyfluorinated aromatic ethers and thioethers by synergistic cleavage of C-B bond and C-F bond of B(C6F5)3》.Category: pyridine-derivatives The article contains the following contents:

A concise and efficient method for the synthesis of polyfluorinated aromatic ethers 2,3,5,6-F4C6HOR (R = 3-nitrophenyl, 1-naphthyl, quinolin-5-yl, etc.) and thioethers 2,3,5,6-F4C6HSR1 (R1 = benzyl, cyclohexyl, naphth-2-yl, etc.) by synergistic cleavage of C-B bond and C-F bond of B(C6F5)3 is reported. The reaction could proceed smoothly with excellent functional-group compatibility. In addition, the transformation represents the first general application of B(C6F5)3 as reaction partners in cross-coupling reaction. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mihai, Madalina T.; Davis, Holly J.; Genov, Georgi R.; Phipps, Robert J. published 《Ion Pair-Directed C-H Activation on Flexible Ammonium Salts: meta-Selective Borylation of Quaternized Phenethylamines and Phenylpropylamines》.ACS Catalysis published the findings.Formula: C7H9NO The information in the text is summarized as follows:

Ion pairing has unexplored potential as a key catalyst-substrate interaction for controlling regioselectivity and site-selectivity in transition-metal catalysis, particularly in the area of C-H activation. However, there is a significant perceived challenge that has meant that few have investigated this approach to date-that of the low directionality, which could present an unsurmountable challenge if seeking positional selectivity on flexible substrates. Herein, we demonstrate that even flexible substrates with several freely rotatable bonds undergo ion pair-directed C-H borylation with good to excellent levels of regiocontrol for the arene meta-position. Furthermore, we demonstrate that in specially designed competition substrates, ion pair direction prevails over competing hydrogen bond direction. We anticipate that these findings will inspire the greater incorporation of ion-pairing into site-selective catalytic strategies. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2In 2017 ,《Mechanism and Stereocontrol in Isotactic rac-Lactide Polymerization with Copper(II) Complexes》 appeared in ACS Catalysis. The author of the article were Daneshmand, Pargol; van der Est, Art; Schaper, Frank. The article conveys some information:

Reaction of N-R,N’-R’-2,5-diiminopyrroles (R = R’ = S-CH(Me)Ph; R = R’ = CH2Ph; R = S-CH(Me)Ph, R’ = H) with Cu(OMe)2 in the presence of chelating alcs., ROH (R1 = C2H4NMe2, R2 = C2H4Py, R3 = CH2Py, R4 = CMe2Py) yielded the dinuclear, alkoxide-bridged complexes L2Cu2(OR)2. The complexes catalyze the polymerization of rac-lactide at room temperature with catalyst concentrations of 1-3 mM in 4-24 h (v = k[cat][monomer] with k = [2.3(5)] × 102 – [6.5(6)] × 102 M-1 h-1). EPR and mechanistic studies indicate that the complexes remain dinuclear during the polymerization reaction. In complexes with OR1, both alkoxides of the dimer initiate polymerization, with OR2 or OR3 only one alkoxide initiates polymerization, and OR4 is inactive in polymerization The nature of the bridging ligand in the dinuclear complex determines stereocontrol. Independent of the spectator ligand L, complexes which retain an OR3 or OR4 bridging ligand in the active species show preference for isotactic polymerizations (Pm = 0.60-0.75), while those with only polymeryloxo bridges or OR2 as the bridging ligand provide atactic polymer. Stereocontrol follows a chain-end control mechanism, with the catalytic site likely adapting to the configuration of the chain end. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Preparation of the Ru3(CO)8-pyridine-alcohol cluster and its use for the selective catalytic transformation of primary to secondary amines》 appeared in Dalton Transactions. The author of the article were Singh, Ajeet; Mobin, Shaikh M.; Mathur, Pradeep. The article conveys some information:

The synthesis of pyridine alc. based ruthenium carbonyl clusters Ru3(hep)2(CO)8 , Ru3(hpp)2(CO)8 , and Ru3(bhmp-H)2(CO)8 {hep-H = 2-(2-hydroxyethyl)pyridine, hpp-H = 2-(3-hydroxypropyl)pyridine and bhmp-H2 = 2,6-bis(hydroxymethyl)pyridine} was carried out by the reaction of the corresponding pyridine-alc. ligands with Ru3(CO)12. Clusters Ru3(hep)2(CO)8 , Ru3(hpp)2(CO)8 , and Ru3(bhmp-H)2(CO)8 were characterized using elemental anal., NMR, FTIR, mass spectrometry and single-crystal x-ray structures. The clusters were explored for the selective catalytic transformation of primary amines into secondary amines using alcs. as the mono-alkylating agents via hydrogen transfer reactions. All three display efficient catalytic activity with 1 being the most effective.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages》 were Lucy, Daniel; Purvis, Gareth S. D.; Zeboudj, Lynda; Chatzopoulou, Maria; Recio, Carlota; Bataille, Carole J. R.; Wynne, Graham M.; Greaves, David R.; Russell, Angela J.. And the article was published in ACS Chemical Biology in 2019. Related Products of 103-74-2 The author mentioned the following in the article:

GPR84 is an orphan G-protein-coupled receptor that is expressed on immune cells and implicated in several inflammatory diseases. The validation of GPR84 as a therapeutic target is hindered by the narrow range of available chem. tools and consequent poor understanding of GPR84 pathophysiol. Here we describe the discovery and characterization of DL-175, a potent, selective, and structurally novel GPR84 agonist and the first to display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells. By comparing DL-175 with reported GPR84 ligands, we show for the first time that biased GPR84 agonists have markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement. This work demonstrates that biased agonism at GPR84 enables the selective activation of functional responses in immune cells and delivers a high-quality chem. probe for further investigation. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2022 ,《Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives》 was published in Organic Letters. The article was written by Monteith, John J.; Scotchburn, Katerina; Mills, L. Reginald; Rousseaux, Sophie A. L.. The article contains the following contents:

A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of thiocarboxylic acid derivatives has been developed. This method benefits from a fast reaction time, mild reaction conditions and ease of starting material synthesis. The use of transition metal catalysis to access a diverse range of thiocarbonyl containing compounds provides a useful complementary approach when compared to previously established methodologies. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Mohammad, Akbar; Chandra, Prakash; Ghosh, Topi; Carraro, Mauro; Mobin, Shaikh M. published 《Facile Access to Amides from Oxygenated or Unsaturated Organic Compounds by Metal Oxide Nanocatalysts Derived from Single-Source Molecular Precursors》.Inorganic Chemistry published the findings.SDS of cas: 103-74-2 The information in the text is summarized as follows:

Oxidative amidation is a valuable process for the transformation of oxygenated organic compounds to valuable amides. However, the reaction is severely limited using an expensive catalyst and limited substrate scope. To circumvent these limitations, designing a transition-metal-based nanocatalyst via more straightforward and economical methodol. with superior catalytic performances with broad substrate scope is desirable. To resolve the aforementioned issues, the authors report a facile method for the synthesis of nanocatalysts NiO and CuO by the sol-gel-assisted thermal decomposition of [Ni(hep-H)(H2O)4]SO4 (SSMP-1) and [Cu(μ-hep)(BA)]2 (SSMP-2) [hep-H = 2-(2-hydroxylethyl)pyridine; BA = HOBz] as single-source mol. precursors (SSMPs) for the oxidative amidation of benzyl alc., benzaldehyde, and BA by using DMF as the solvent and as an amine source, in the presence of tert-butylhydroperoxide (TBHP) as the oxidant, at T = 80°. In addition to nanocatalysts NiO and CuO, the authors’ previously reported Co/CoO nanocatalyst (CoNC), derived from [CoII(hep-H)(H2O)4]SO4 (A) as an SSMP, was also explored for the aforementioned reaction. Also, the authors have carefully studied the difference in the catalytic performance of Co-, Ni-, and Cu-based nanoparticles synthesized from the SSMP for the conversion of various oxygenated and unsaturated organic compounds to their resp. amides. CuO showed an optimum catalytic performance for the oxidative amidation of various oxygenated and unsaturated organic compounds with a broad reaction scope. Finally, CuO can be recovered unaltered and reused for several (six times) recycles without any loss in catalytic activity. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Green Chemistry included an article by Chakrabarti, Kaushik; Mishra, Anju; Panja, Dibyajyoti; Paul, Bhaskar; Kundu, Sabuj. Reference of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources》. The information in the text is summarized as follows:

A Ru(II) complex mediated synthesis of various N,N-di-Me and N-monomethyl amines from organic azides using methanol as a methylating agent was reported. This methodol. was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 103-74-2In 2019 ,《Novel silver(I) complexes bearing mefenamic acid and pyridine derivatives: Synthesis, chemical characterization and in vitro anticancer evaluation》 was published in Inorganica Chimica Acta. The article was written by Altay, Ahmet; Caglar, Sema; Caglar, Bulent; Sahin, Zarife Sibel. The article contains the following contents:

Two Ag(I) complexes [Ag2(μ-mef)2(2-pymet)2] (1), [Ag2(μ-mef)2(2-pyet)2] (2) containing mefenamic acid, 2-pyridinemethanol and 2-pyridineethanol were synthesized and characterized by using SCXRD, FTIR, elemental and thermal anal. techniques. 1 Was synthesized as a single crystal whereas 2 was obtained as a microcrystalline powder. 1 Consists of binuclear structure. The argentophilic interaction occurs among silver(I) ions due to the short Ag···Ag distance (2.8710(10) Å). Two Ag(I) centers are connected by carboxylato oxygen-bridge to form the binuclear metal core. The FTIR spectra and thermal anal. studies confirmed that both complexes exhibited similar structures. In vitro antiproliferative activity of both complexes were evaluated against MCF-7, HT-29 and HepG2 cancer cell lines. The apoptotic effects and intracellular ROS generation from both complexes were investigated in MCF-7 cell line by flow cytometry anal. The XTT and LDH assays revealed that both complexes showed strong antiproliferative activity with higher selectivity towards cancer cells compared to the normal cells. Annexin V/propidium iodide assay exhibited that apoptotic cell number was increased in MCF-7 cells with increasing concentrations of Ag(I) complexes. Also, both complexes induced the ROS generation considerably in MCF-7 cells suggesting the possible pro-oxidant activity of the novel synthesized Ag(I) complexes. Taken together, these findings provide a notable support for potential utility of Ag(I) complexes as novel anticancer agents against numerous kind of carcinogenesis. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2HPLC of Formula: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. HPLC of Formula: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Bhatt, V. P.; Samant, S. D.; Pednekar, Suhas published 《Nucleophilic addition of arylmethylzinc reagents (ArCH2ZnCl) to formaldehyde: An easy access to 2-(hetero)arylethyl alcohols》.Synthetic Communications published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

The nucleophilic addition of benzyl zinc reagents derived from inexpensive and abundant benzyl chlorides to paraformaldehyde was reported. The reaction investigated herein is hitherto unknown and was found to be selective, operationally simple, atom- and step-economical and high yielding to deliver phenethyl alcs. utilized as key perfumery ingredients in 60-83% yields. After successful establishment of the reaction condition, the reaction was also scaled up successfully to deliver a large-scale preparation of the phenethyl alc.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem