Category: 103-74-2

In 2018,ACS Catalysis included an article by Siddiki, S. M. A. Hakim; Touchy, Abeda S.; Jamil, A. R. Md.; Toyao, Takashi; Shimizu, Ken-ichi. Safety of 2-(2-Hydroxyethyl)pyridine. The article was titled 《C-Methylation of Alcohols, Ketones, and Indoles with Methanol Using Heterogeneous Platinum Catalysts》. The information in the text is summarized as follows:

A versatile, selective, and recyclable heterogeneous catalytic method for the methylation of C-H bonds in alcs., ketones, and indoles with methanol under oxidant-free conditions using a Pt-loaded carbon (Pt/C) catalyst in the presence of NaOH is reported. This catalytic system is effective for various methylation reactions: (1) the β-methylation of primary alcs., including aryl, aliphatic, and heterocyclic alcs., (2) the α-methylation of ketones, and (3) the selective C3-methylation of indoles. The reactions are driven by a borrowing-hydrogen mechanism. The reaction begins with the dehydrogenation of the alc.(s) to afford aldehydes, which subsequently undergo a condensation reaction with the nucleophile (aldehyde, ketone, or indole), followed by hydrogenation of the condensation product by Pt-H species to yield the desired product. In all of the methylation reactions explored in this study, the Pt/C catalyst exhibits a significantly higher turnover number than other previously reported homogeneous catalytic systems. Moreover, it is demonstrated that the high catalytic activity of Pt can be rationalized in terms of the adsorption energy of hydrogen on the metal surface, as revealed by d. functional theory calculations on different metal surfaces. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Scalable and Phosphine-Free Conversion of Alcohols to Carbon-Heteroatom Bonds through Blue-Light Promoted Iodination Reaction》 was published in Journal of Organic Chemistry in 2020. These research results belong to Liu, Bin; Elder, W. Zachary; Miyake, Garret M.. Recommanded Product: 2-(2-Hydroxyethyl)pyridine The article mentions the following:

A simple route toward the diverse conversion of alcs. via an SN2 pathway, in which blue light promoted iodination is used to form alkyl iodide intermediates from simple unreactive alcs. ROH [R = hex-5-yn-1-yl, 2-(1H-indol-3-yl)ethyl, cyclopentyl, etc.] was reported. The scope of the process tolerates a range of nucleophiles R1H [R1 = CN, (4-bromophenyl)carbonyloxidanyl, quinolin-6-yloxidanyl, (furan-2-yl)carbonyloxy, etc.] to construct C-N, C-O, C-S, and C-C bonds. Furthermore, this method can be used for the preparation and late stage functionalization of pharmaceuticals, as highlighted by the synthesis of thiocarlide, butoxycaine, and pramoxine. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Hong; Wang, Guanghui; Li, Pengfei published 《Iridium-catalyzed intermolecular directed dehydrogenative ortho C-H silylation》.Organic Chemistry Frontiers published the findings.Computed Properties of C7H9NO The information in the text is summarized as follows:

An efficient method for iridium-catalyzed direct silylation of C(sp2)-H and C(sp3)-H bonds using HSiMe(OSiMe3)2 as the silylating reagent is described. The reaction is amenable to various directing groups under simple and mild conditions leading to the mono- and regioselective synthesis of versatile organosilane compounds2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yuan, Lei; Gao, Hongshuai; Jiang, Haiyan; Zeng, Shaojuan; Li, Tao; Ren, Baozeng; Zhang, Xiangping published their research in Journal of Molecular Liquids in 2021. The article was titled 《Experimental and thermodynamic analysis of NH3 absorption in dual-functionalized pyridinium-based ionic liquids》.Related Products of 103-74-2 The article contains the following contents:

A novel type of dual-functionalized pyridinium-based ionic liquids (ILs) with acidic protons and hydroxyl groups, were designed and synthesized for ammonia (NH3) absorption. The NH3 absorption isotherms in dualfunctionalized pyridinium-based ILs at temperatures from 303.15 to 343.15 K and pressures up to 600 kPa were computed using gas-liquid equilibrium method. It revealed that 4-pyridinemethanol bis (trifluoromethane)sulfonamide [4-MeOHPy][NTf2] showed the maximum NH3 solubility of 3.43 mol NH3/mol IL at 313.15 K and atm. pressure, surpassing any nonmetallic ILs previously reported. Furthermore, the characteristics of isotherms under low pressures behaved an obvious chem. reaction between ILs and NH3, and all exptl. solubilities were regulated by a reaction equilibrium thermodn. model (RETM). The thermodn. properties were further obtained to better understand the NH3 absorption process. The results indicated that this model endorses the 1:1 (NH3-IL) mole ratio of chem. reaction mechanism and the reaction enthalpy is main driving force of NH3 absorption in ILs. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2017 ,《Magneto-structural correlations in a family of di-alkoxo bridged chromium dimers》 appeared in Dalton Transactions. The author of the article were Fraser, Hector W. L.; Nichol, Gary S.; Velmurugan, Gunasekaran; Rajaraman, Gopalan; Brechin, Euan K.. The article conveys some information:

A series of di-alkoxo bridged Cr(III) dimers were synthesized using pyridine alc. ligands. The structures fall into four general categories and are of formula: [Cr2(OMe)2(pic)4]·0.5MeOH·0.5Et2O (1), [Cr2(hmp)2(pic)2X2] (X = Cl (2), Br (3)), [Cr2(L)2Cl4(A)2]·2S (L = hmp, A = H2O and S = Et2O (4); L = hmp, A = pyridine and S = pyridine (5); L = hmp, A = 4-picoline and no S (6); L = hep, A = H2O and S = MeCN (7)), and [Cr(hmp)(hmpH)Cl2]·MeCN (8). D.c. (d.c.) magnetic susceptibility measurements show relatively weak antiferromagnetic exchange interactions between the Cr(III) centers with J values <|15| cm-1 in all of the complexes measured. DFT calculations performed on complexes 1-8 reproduce both the sign and strength of the exchange interactions found exptl., and confirm that the magnitude and sign of the J value is strongly dependent upon the orientation of the dihedral angle formed between the bridging Cr2O2 plane and the O-R vector of the bridging group (θ), and the Cr-O-Cr-O dihedral angle (ψ). After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Huang, Pan; Le, Xiangyang; Huang, Fei; Yang, Jie; Yang, Haofeng; Ma, Junlong; Hu, Gaoyun; Li, Qianbin; Chen, Zhuo. Category: pyridine-derivatives The article mentions the following:

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biol. evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f(I) was much more efficient than the pos. compound apcin in inhibiting cancer cell growth, but it had approx. the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ynamide-Mediated Intermolecular Esterification》 was written by Wang, Xuewei; Yang, Yang; Zhao, Yongli; Wang, Sheng; Hu, Wenchang; Li, Jinmei; Wang, Zihao; Yang, Fengling; Zhao, Junfeng. Quality Control of 2-(2-Hydroxyethyl)pyridine And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An ynamide-mediated one-pot, two-step intermol. esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species is reported. A broad substrate scope with respect to carboxylic acids, alcs., and phenols is observed The α-acyloxyenamide intermediates formed by the addition of carboxylic acids to ynamides proved to be effective acylating reagents for the esterification of alc. and phenol derivatives with the assistance of base catalysis. Notably, the racemization of the α-chiral center of carboxylic acids can be avoided. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2In 2017 ,《Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication》 was published in Journal of Natural Products. The article was written by Lin, Yongsheng; Wang, Qian; Gu, Qiong; Zhang, Hongao; Jiang, Cheng; Hu, Jiayuan; Wang, Yan; Yan, Yuan; Xu, Jun. The article contains the following contents:

(+)-Rutamarin inhibits EBV lytic DNA replication with an IC50 of 7.0 μM. (-)-Chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of Ruta graveolens and used as a precursor of (-)-rutamarin. Altogether, 28 (-)-rutamarin derivatives were synthesized starting from (-)-chalepin. Of these, 16 compounds were found to be more potent against EBV lytic DNA replication than (-)-chalepin. Three compounds exhibited IC50 values of 1.5, 0.32, and 0.83 μM and showed selectivity index values (SI) of 801, 211, and >120, resp. Thus, these 3 compounds are considered promising leads for further laboratory investigation. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Zhang, Wen-Man; Dai, Jian-Jun; Xu, Jun; Xu, Hua-Jian published 《Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides》.Journal of Organic Chemistry published the findings.Related Products of 103-74-2 The information in the text is summarized as follows:

A photoredox catalytic method has been developed for the direct C2 alkylation of pyridine N-oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2-alkylated pyridine N-oxides under mild conditions. Mechanistic studies are consistent with the generation of a radical intermediate along the reaction pathway. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chen, Long; Zhu, Yueyue; Chen, Tieqiao; Liu, Long; Zhang, Ji-Shu; Han, Li-Biao published 《Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides》.Organic & Biomolecular Chemistry published the findings.Reference of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcs. and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem