Category: 103-74-2

Harnying, Wacharee; Sudkaow, Panyapon; Biswas, Animesh; Berkessel, Albrecht published an article in 2021. The article was titled 《N-Heterocyclic Carbene/Carboxylic Acid Co-Catalysis Enables Oxidative Esterification of Demanding Aldehydes/Enals, at Low Catalyst Loading》, and you may find the article in Angewandte Chemie, International Edition.SDS of cas: 103-74-2 The information in the text is summarized as follows:

The discovery that simple carboxylic acids, such as benzoic acid, boost the activity of N-heterocyclic carbene (NHC) catalysts in the oxidative esterification of aldehydes RCHO (R = heptan-3-yl, Ph, 1-[4-(propan-2-yl)phenyl]propan-2-yl, 6-methylhept-5-en-2-yl, etc.) was reported. A simple and efficient protocol for the transformation of a wide range of sterically hindered α- and β-substituted aliphatic aldehydes/enals, catalyzed by a novel and readily accessible N-Mes-/N-2,4,6-trichlorophenyl 1,2,4-triazolium salt, and benzoic acid as co-catalyst, was developed. A whole series of α/β-substituted aliphatic aldehydes/enals hitherto not amenable to NHC-catalyzed esterification could be reacted at typical catalyst loadings of 0.02-1.0 mol%. For benzaldehyde, even 0.005 mol% of NHC catalyst proved sufficient: the lowest value ever achieved in NHC catalysis. Preliminary studies point to carboxylic acid-induced acceleration of acyl transfer from azolium enolate intermediates as the mechanistic basis of the observed effect.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Shu, Bing; Cao, Jiaojiao; Kuang, Guotao; Qiu, Jun; Zhang, Meiling; Zhang, Yan; Wang, Mingxue; Li, Xiaoya; Kang, Shuangshuang; Ou, Tian-Miao; Tan, Jia-Heng; Huang, Zhi-Shu; Li, Ding published 《Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C7H9NO The information in the text is summarized as follows:

We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 (I) could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Journal of the American Chemical Society included an article by MacQueen, Preston M.; Tassone, Joseph P.; Diaz, Carlos; Stradiotto, Mark. Synthetic Route of C7H9NO. The article was titled 《Exploiting Ancillary Ligation To Enable Nickel-Catalyzed C-O Cross-Couplings of Aryl Electrophiles with Aliphatic Alcohols》. The information in the text is summarized as follows:

The use of (L)Ni(o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos, I or II, resp.) enables the C(sp2)-O cross-coupling of primary, secondary, or tertiary aliphatic alcs. with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C(sp2)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Synthetic Route of C7H9NO) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the Brazilian Chemical Society included an article by de Mello, Murilo B. M.; de Oliveira, Antonio A. F.; de Oliveira, Caroline L.; Ultramari, Mariah A.; Gama, Fernando H. S.; Mascarello, Alessandra; Guimaraes, Cristiano R. W.; de Freitas, Miller N.; Cunha, Carlos E.; Lourenco, Tiago C.; Ferreira, Fernanda P.; Lopesa, Joao L. C.; Clososki, Giuliano C.. Category: pyridine-derivatives. The article was titled 《Characterization and in silico mutagenic assessment of a new betahistine degradation impurity》. The information in the text is summarized as follows:

Currently, the pharmaceutical industry devotes great attention to drug degradation products because these compounds can offer risks to patients. A previous degradation study of betahistine (N-α-methyl-2-pyridylethylamine) conducted under different stress conditions detected three main impurities named A, B and C. Degradation products were analyzed by high-resolution mass spectrometry in electrospray source and time of flight analyzer (ESI-TOF) and NMR (NMR). Impurity mutagenicity was evaluated by Derek Nexus and Sarah Nexus softwares. Liquid chromatog. hyphenate with tandem mass spectrometry (LC-MS/MS) anal. of the betahistine forced degradation sample indicated the presence of a new impurity, which was named impurity C1. 2D NMR experiments allowed the complete structural characterization of the new entity. The active pharmaceutical ingredient and degradation impurities were classified as inactive in the in silico mutagenic studies. Systematic investigation of a forced degradation sample led to the characterization of a new betahistine impurity. The in silico mutagenicity study of the betahistine degradation impurities may be useful in the risk assessment of the drug products. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mou, Xue-Qing; Chen, Xiang-Yu; Chen, Gong; He, Gang published 《Radical-mediated intramolecular β-C(sp3)-H amidation of alkylimidates: facile synthesis of 1,2-amino alcohols》.Chemical Communications (Cambridge, United Kingdom) published the findings.Product Details of 103-74-2 The information in the text is summarized as follows:

A new radical-mediated intramol. β-C(sp3)-H amidation reaction of O-alkyl trichloro- or arylimidates is reported. Various oxazolines were efficiently prepared from easily accessible alc. starting materials. The trichloro-oxazoline products can be hydrolyzed under mild conditions to give valuable 1,2-amino alcs. This amidation reaction exhibits a broad substrate scope and good functional group tolerance, and offers a powerful means for the C(sp3)-H functionalization of alcs. Mechanistic studies suggest that a sequence of 1,5-HAT of an imidate radical, iodination and cyclization might be operative. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Product Details of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Polydentate 4-Pyridyl-terpyridine Containing Discrete Cobalt Phosphonate and Polymeric Cobalt Phosphate as Catalysts for Alcohol Oxidation》 appeared in Zeitschrift fuer Anorganische und Allgemeine Chemie. The author of the article were Bhat, Gulzar A.; Rajendran, Antony; Murugavel, Ramaswamy. The article conveys some information:

Mononuclear discrete cobalt phosphonate [Co(pytpy)(tBuPO3H)2(H2O)]·H2O (1) and 1D zigzag polymeric cobalt phosphate [Co(pytpy)2(dipp)(MeOH)·2MeOH]n (2) were prepared from the reactions of tert-Bu phosphonic acid (tBuPO3H2) and organic-soluble 2,6-diisopropylphenyl phosphate (dippH2) ligands with Co(OAc)2·4H2O in the presence of 4-pyridyl 2,2:6,2-terpyridine in MeOH/CHCl3(1:1 volume/volume) solvent mixture at 25 °C. The new compounds were characterized by anal., thermo-anal., and spectroscopic techniques. Further, the mol. structures were established by single-crystal X-ray diffraction studies. Mass spectrometry anal. reveal that both the compounds exist in the solution phase as dimers. Compound 1 was employed as homogeneous catalysts for alc. oxidation reactions using tert-Bu hydroperoxide (TBHP) as the oxidant. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Xin; Lv, Huichao; Yang, Liguo; Dai, Yuqiang published 《Crystal structure of bis(μ2-azido-κ2N:N)-dichlorido-bis(μ2-2-(pyridin-2-yl)ethan-1-ol-κ2O,N)dicopper(II), C14H18Cl2Cu2N8O2》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

C14H18Cl2Cu2N8O2, monoclinic, P21/n (number 14), a = 6.0166(6) Å, b = 15.2792(14) Å, c = 11.5833(12) Å, β = 100.295(1)°, V = 1047.70(18) Å3, Z = 2, Rgt(F) = 0.0412, wRref(F2) = 0.0884, T = 298 K. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Fieser, Megan E.; Schimler, Sydonie D.; Mitchell, Lauren A.; Wilborn, Emily G.; John, Alex; Hogan, Levi T.; Benson, Brooke; LaPointe, Anne M.; Tolman, William B.. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Dual-catalytic decarbonylation of fatty acid methyl esters to form olefins》. The information in the text is summarized as follows:

The homogeneous dehydrative decarbonylation of fatty acid Me esters (FAMEs) to form olefins was reported. In order to facilitate cleavage of the unactivated acyl C-O bond of the alkyl ester, a one pot dual-catalytic directing group strategy was developed through optimization of the individual transesterification and decarbonylation reaction steps. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2020 ,《Synthesis and antimicrobial activities of Schiff base from nitrogen containing heterocycles》 was published in Journal of Applicable Chemistry (Lumami, India). The article was written by Maisuriya, Pratik K.; Soni, Hetal I.; Patel, Jaydeep A.; Patel, Navin B.. The article contains the following contents:

This article dealt with microwave assisted synthesis of Schiff bases N-(aryl)(((pyridinyl)ethoxy)phenyl)methanimines I [R = Ph, 4-MeC6H4, 4-ClC6H4, etc.] from (2-(pyridinyl)ethoxy)benzaldehyde using catalytically amount of concentrateH2SO4 at room temperature MW stimulated synthetic route provided diverse advantages such as reaction rate acceleration, less byproduct, higher yield and reproducibility of final product. The structure of final compounds was established by elemental anal. such as IR, 1H NMR, 13C NMR, mass spectroscopy and also evaluated for their antibacterial, antifungal potency. The biol. potent Schiff base I [R = benzothiazol-2-yl] was found most active against S. aureus (MIC=25μg mL-1) with subjected to reference drug chloramphenicol and ciprofloxacin. The final compounds I [R = 3-ClC6H4, 4-ClC6H4, benzothiazol-2-yl] displayed good antibacterial activity (MIC=50μg mL-1) with reference drug. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Colak, Alper Tolga; Gunay, Handan; Temel, Ersin; Buyukgungor, Orhan; Colak, Ferdag published 《Synthesis, crystal structures, characterization and antimicrobial activities of 5-hydroxyisophthalate complexes》.Transition Metal Chemistry (Dordrecht, Netherlands) published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

Two 5-hydroxyisophthalate complexes of nickel(II), formulated as [Ni(μ-Hhip)(2-hepy)2]n (1) and [Ni2(μ-Hhip)2(dap)4]n (2) (H3hip = 5-hydroxyisophthalic acid, 2-hepy = 2-(2-hydroxyethyl)pyridine, dap = 1,3-diaminopropane), have been synthesized and characterized by chem. and spectroscopic methods. The mol. structures of the complexes have been determined by single-crystal x-ray diffraction anal. The Ni(II) centers have distorted octahedral geometries in both crystals. Furthermore, both complexes have 1D chain structures in which the individual chains are linked together via hydrogen bonds to give 3D frameworks. Evaluation of the complexes by the agar diffusion method showed that they have weak antibiotic activities against the tested microorganisms. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem