Category: 103-74-2

Adding a certain compound to certain chemical reactions, such as: 103-74-2, 2-(2-Hydroxyethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 103-74-2, blongs to pyridine-derivatives compound. Recommanded Product: 103-74-2

To a solution of 2-(2-hydroxyethyl)pyridine (3 ml, 26.6 mmol) was added 30 ml of 33% HBr in acetic acid. The yellow solution was heated in the capped vial at 78 C. for 2 days. The reaction was evaporated under high vacuum to produce a brown solid. The solid was re-crystallized from hot isopropanol to produce a light tan solid (73%). 1H NMR (500 MHz, dMSO): delta 3.62-3.65 (t, 2H), 3.95-3.98 (t, 2H), 7.95 (t, 1H), 8.09-8.10 (d, 1H), 8.58 (t, 1H), 8.90 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,103-74-2, its application will become more common.

Reference:
Patent; Tachdjian, Catherine; Lebl-Rinnova, Marketa; Wallace, David; US2006/263411; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 103-74-2, Adding some certain compound to certain chemical reactions, such as: 103-74-2, name is 2-(2-Hydroxyethyl)pyridine,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103-74-2.

A mixture of 107.5 mg (0.2 mmol) of acid, 45.8 mg (0.22 mmol) of DCC and 6.9 mg (0.05 mmol) of HOBt in 50 ml of DCM is cooled in a bath of ice-cold water. 75.4 mg (0.6 mmol) of the required alcohol are added thereto. The mixture is allowed to warm to room temperature and is stirred for 20 hours. After washing with water, drying (NagSC^) and evaporating, a pasty product is obtained, which is purified by chromatography (SiOa, 1/1 EtOAc/heptane) to give 60 mg (46%) of a pasty product.

According to the analysis of related databases, 103-74-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; WO2006/10423; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 103-74-2, Adding some certain compound to certain chemical reactions, such as: 103-74-2, name is 2-(2-Hydroxyethyl)pyridine,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103-74-2.

A mixture of 107.5 mg (0.2 mmol) of acid, 45.8 mg (0.22 mmol) of DCC and 6.9 mg (0.05 mmol) of HOBt in 50 ml of DCM is cooled in a bath of ice-cold water. 75.4 mg (0.6 mmol) of the required alcohol are added thereto. The mixture is allowed to warm to room temperature and is stirred for 20 hours. After washing with water, drying (NagSC^) and evaporating, a pasty product is obtained, which is purified by chromatography (SiOa, 1/1 EtOAc/heptane) to give 60 mg (46%) of a pasty product.

According to the analysis of related databases, 103-74-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; WO2006/10423; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 103-74-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103-74-2, name is 2-(2-Hydroxyethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

The 250 ml flask is added in three 12.3g (0.1mol) 2-pyridine ethanol, 150 ml ethyl acetate, salt bath under the conditions of the above prepared dropping under stirring 13.1g (0.1mol) mountain ash acid radical chlorine with 50 ml ethyl acetate solution, completion of the dropping, stirring the mixture at room temperature for reaction 2h; filtering, the filter cake is washed with proper amount of ethyl acetate the washing, drying, to obtain light yellow solid 23.6g, yield 92.9%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 103-74-2, 2-(2-Hydroxyethyl)pyridine.

Reference:
Patent; Qingdao University of Science and Technology; Xu, liangzhong; ju, guangxiu; wang, minghui; chen, gexin; xu, shenshen; (7 pag.)CN105503704; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 103-74-2, 2-(2-Hydroxyethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H9NO, blongs to pyridine-derivatives compound. Computed Properties of C7H9NO

Example 15l-(2-Chlorophenyl)-4-methyl-8-(2-pyridin-2-ylethoxy)[l,2,4]triazolo[4,3- a]quinoxaline (B-15)A mixture of compound B-13 (1.5 g, 4.83 mmol), 2-(2-hydroxyethyl)pyridine (0.654 mL, 5.79 mmol), di-tert-butylazadicarboxylate (1.33 g, 5.79 mmol) andtriphenylphosphine (1.52 g, 5.79 mmol), in THF (36 mL) was heated in a microwave oven for 20 min at 120 C (the reaction mixture was divided in three batches). Then 1 equiv. more of di-tert-butylazadicarboxylate and triphenylphosphine were added and the r.m. was heated again at the same conditions as before. Then the solvent was evaporated, the crude compound taken up in aq. sat. NaHC03 and then extracted with DCM. The organic layer was separated, dried (Na2S04), filtered and the solvent concentrated in vacuo. The crude mixture was purified by chromatography (silica, MeOH in EtOAc 0: 100 to 15:85) to give an oil that was made solid by addition of diethylether to yield final product B-15 as white solid (1.32 g, 65.7%). 1H NMR (500 MHz, CDCls) delta ppm 3.04 (s, 3 H), 3.14 (t, J=6.8 Hz, 2 H), 3.91 – 4.05 (m, 2 H), 6.67 (d, J=2.6 Hz, 1 H), 7.11 (dd, J=9.2, 2.6 Hz, 1 H), 7.17 (d, J=8.4 Hz, 1 H), 7.18 – 7.24 (m, 1 H), 7.48 – 7.54 (m, 2 H), 7.56 – 7.61 (m, 1 H), 7.64 (td, J=7.7, 1.9 Hz, 1 H), 7.68 (dd, J=5.9, 3.3 Hz, 1 H), 7.92 (d, J=9.0 Hz, 1 H), 8.57 (d, J=4.3 Hz, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,103-74-2, 2-(2-Hydroxyethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANDRES-GIL, Jose, Ignacio; ROMBOUTS, Frederik, Jan, Rita; TRABANCO-SUAREZ, Andres, Avelino; VANHOOF, Greta, Constantia, Peter; DE ANGELIS, Meri; BUIJNSTERS, Peter, Jacobus, Johannes, Antonius; GUILLEMONT, Jerome, Emile, Georges; BORMANS, Guy, Maurits R.; CELEN, Sofie, Jeanne, Leopoldine; VLIEGEN, Maarten; WO2013/924; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 103-74-2, 2-(2-Hydroxyethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H9NO, blongs to pyridine-derivatives compound. HPLC of Formula: C7H9NO

General procedure: To a solution of A1B1 (1.0mmol) and triphenylphosphine (1.5mmol) in anhydrous tetrahydrofuran (3mL), added C1 or C2 (2.0mmol) and dropwise added diethyl azodicarboxylate (DEAD, 1.5mmol) in anhydrous and anoxybiotic conditions. The reaction mixture was stirred at-2C for 30min, and then stirred at room temperature for 24h. After completion of reaction was monitored through TLC, the reaction mixture was filtered and washed with ether and saturated salt water to get products because there would be a solid precipitate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,103-74-2, 2-(2-Hydroxyethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Article; Wang, Fang; Sun, Jun-Rong; Huang, Mei-Yan; Wang, Hui-Ying; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min; European Journal of Medicinal Chemistry; vol. 72; (2014); p. 35 – 45;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem