Category: 103041-38-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103041-38-9, name is Ethyl 3-(pyridin-2-ylamino)propanoate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C10H14N2O2

obtained in Step 1 19.3g (0.098mol) of Compound 2 was added to the reaction flask was added 100ml of ethyl acetate, taking 22.8g (0.12mol) N-2 -B- alanine ethyl ester pyridine i.e. compound 3, was dissolved in 50ml of ethyl acetate was added to the reaction solution, 25 stirred for 12h, the solvent was distilled off under reduced pressure (vacuum degree: 0.075Mpa; temperature: 50 ) to give a solid, 65 deg.] C, and dried under vacuum 0.08Mpa 2h, was 28.9g3- [4-methoxy-3-methyl -N- (2- pyridyl) – benzamido] – acrylic acid ethyl ester, compound 4 in a yield of 80.7%

With the rapid development of chemical substances, we look forward to future research findings about 103041-38-9.

Reference:
Patent; Kaifeng Baiyun Pharmacy Limited Company; Lin, hengbiao; zhu, zanmei; mao, ying; liu, zhiqing; li, yunduo; (8 pag.)CN105481831; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103041-38-9, name is Ethyl 3-(pyridin-2-ylamino)propanoate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C10H14N2O2

EXAMPLE 1 Preparation of Ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]-propanoate (II) 100 g of compound I was dissolved in 1 L of dichloromethane under nitrogen atmosphere and cooled to 0-5 C. Thionyl chloride was added to the reaction mixture for 1 h and the reaction mixture was boiled to reflux. Maintained the reaction mass under the same temperature for 5-6 h. After completion of the reaction, excess thionyl chloride was removed by co-distillation with dichloromethane and finally the solvent was completely removed under vacuum. The acid chloride was then dissolved in dichloromethane under an inert atmosphere and triethyl amine was added to the reaction mixture. To the reaction mixture was added slowly a solution of ethyl-3-(pyridine-2-ylamino) propanoate in dichloromethane. The reaction mixture was maintained at the same temperature for another 6-12 h. After completion of the reaction, the reaction mass was diluted water and extracted the product with dichloromethane. The combined organic layers were separated and dried over anhydrous sodium sulphate. The solvent was distilled off under vacuum and the product was purified by hexane. Yield: 80%, HPLC: >98%

With the rapid development of chemical substances, we look forward to future research findings about 103041-38-9.

Reference:
Patent; Biophore India Pharmeuticals PVT. Ltd.; Pullagurla, Manik Reddy; Rangisetty, Jagadeesh Babu; Nandakumar, Mecheril Valsan; (8 pag.)US2015/246900; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103041-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103041-38-9, name is Ethyl 3-(pyridin-2-ylamino)propanoate. This compound has unique chemical properties. The synthetic route is as follows.

c) Ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)aminolpropanoate hydrochloride [Show Image] 50 g (0.25 mol) of 4-(methylamino)-3-nitrobenzoic acid as obtained in step (a) were suspended in a mixture of 459.2 g of thionyl chloride and 3 mL of N,N-dimethylformamide. The mixture was stirred at reflux temperature for 45 minutes. Excess thionyl chloride was removed by vacuum distillation. The residue was dissolved in 300 mL of toluene, which was subsequently removed by vacuum distillation to remove completely any residual thionyl chloride. The brownish crystalline residue obtained was dissolved in 280 mL of tetrahydrofuran at 60C. At this point, 35.1 g of triethylamine were added to the solution. Then, a solution of 45 g (0.23 mol) of ethyl 3-(2-pyridylamino)propanoate as obtained in step (b) in 95 mL of tetrahydrofuran was added dropwise over the reaction mixture, keeping the temperature at about 30C. The resulting mixture was stirred overnight at room temperature. Solvent was removed by vacuum distillation, and the residue was dissolved in 1 L of dichloromethane. The resulting solution was washed with 500 mL of water, 500 mL of 2M hydrochloric acid, 500 mL of saturated sodium bicarbonate and 500 mL of water. The organic phase was dried with anhydrous sodium sulfate and concentrated under vacuum. The residue was dissolved with 600 mL of ethyl acetate, and dry hydrogen chloride was bubbled into the solution until precipitation was completed. The solid was isolated by filtration and dried to obtain 63 g of the title compound, which was recrystallized in a mixture of 450 mL of ethanol and 50 mL of acetonitrile at reflux temperature. After cooling to 10C, solid was isolated by filtration and dried to yield 44.7 g of ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate hydrochloride as a yellow solid. Yield: 47.2 %. Purity (HPLC, method 1): 97.6 %.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 103041-38-9, Ethyl 3-(pyridin-2-ylamino)propanoate.

Reference:
Patent; Medichem, S.A.; EP2522662; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.103041-38-9, name is Ethyl 3-(pyridin-2-ylamino)propanoate, molecular formula is C10H14N2O2, molecular weight is 194.23, as common compound, the synthetic route is as follows.COA of Formula: C10H14N2O2

The embodiment of the 6 products obtained 10g, adding tetrahydrofuran 100 ml dissolved, adding 3.2gDBU, 4 . 5g3 – (pyridin-2-yl amino) propionic acid ethyl ester, the temperature is increased to 50 C reaction 7 hours, TLC (developing solvent: ethyl acetate: petroleum ether = 4:1) determine the end point of the reaction. After the completion of reaction, concentrating under reduced pressure to dry. Residue using ethyl acetate 150 ml dissolved, water 100 ml washing secondary, after drying with anhydrous sodium sulfate concentrated under reduced pressure to dry. Residue plus isopropanol refining to obtain a target compound product, yield 82.6%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,103041-38-9, Ethyl 3-(pyridin-2-ylamino)propanoate, and friends who are interested can also refer to it.

Reference:
Patent; Chongqing Institute of Pharmaceutical Industry Co., Ltd.; Xing, Naiguo; Wang, Li; Cai, Pengfei; Zheng, Deping; (14 pag.)CN105523999; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem