Category: 1033203-41-6

Application of 1033203-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine, molecular formula is C5H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 6-bromopyridine-3,4-diamine 7 (2 g, 10.6 mmol) in NaNO. (2M, 25 mL) was added Acetic acid (20 mL) and stirred at 0C for 15 min and heated the contents of the reaction at 70C for 1.5 h. The reaction was cooled, poured in crushed ice the precipitated solid was filtered, dried and washed with diethyl ether to get e-bromo-SH-n^.Sltriazolo^S-clpyridine (1.0 g, 47%) as off-white solid. LC-MS (method 23): Rt = 1.26 min; m/z = 201.00 (M+H++2).

According to the analysis of related databases, 1033203-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1033203-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine, molecular formula is C5H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 6-bromopyridine-3,4-diamine 7 (2 g, 10.6 mmol) in NaNO. (2M, 25 mL) was added Acetic acid (20 mL) and stirred at 0C for 15 min and heated the contents of the reaction at 70C for 1.5 h. The reaction was cooled, poured in crushed ice the precipitated solid was filtered, dried and washed with diethyl ether to get e-bromo-SH-n^.Sltriazolo^S-clpyridine (1.0 g, 47%) as off-white solid. LC-MS (method 23): Rt = 1.26 min; m/z = 201.00 (M+H++2).

According to the analysis of related databases, 1033203-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1033203-41-6 ,Some common heterocyclic compound, 1033203-41-6, molecular formula is C5H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0287] Reference V -bromo-2,3-dichloropyrido[3,4-b]pyrazine [0290] Step 1 : 7-bromopyrido[3,4-b]pyrazine-2,3(lH,4H)-dione hydrochloride [0291] To a solution of 6-bromopyridine-3,4-diamine (467 mg, 2.484 mmol) in HC1 (3726 mu, 14.90 mmol, 4 M aq) was added oxalic acid (257 mg, 2.86 mmol). The mixture was heated at 120 C for 14 h then filtered, washed with cold water and dried under vacuum to yield the title compound as a tan solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1033203-41-6, its application will become more common.

Reference:
Patent; ENVOY THERAPEUTICS, INC.; HITCHCOCK, Stephen; MONENSCHEIN, Holger; REICHARD, Holly; SUN, Huikai; KIKUCHI, Shota; MACKLIN, Todd; HOPKINS, Maria; WO2014/28479; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine. A new synthetic method of this compound is introduced below., COA of Formula: C5H6BrN3

6-Bromopyridine-3,4-diamine (200.0 mg, 1.06 mmol) was added to diethyl oxalate (3.0 mL). The mixture was stirred at 130 C. for 12 hours and then cooled to room temperature. Et2O was added thereto to form a solid. The formed solid was filtered and dried under reduced pressure to obtain brown solid compound of 7-bromopyrido[3,4-b]pyrazine-2,3-diol (195.0 mg, 76%). [1236] 1H-NMR (400 MHz, DMSO-d6); delta: 12.23 (brs, 1H), 12.11 (brs, 1H), 8.09 (s, 1H), 7.05 (s, 1H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1033203-41-6, 6-Bromopyridine-3,4-diamine.

Reference:
Patent; C&C RESEARCH LABORATORIES; Ho, Pil Su; Yoon, Dong Oh; Han, Sun Young; Lee, Won Il; Kim, Jung Sook; Park, Woul Seong; Ahn, Sung Oh; Kim, Hye Jung; US2014/315888; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine. A new synthetic method of this compound is introduced below., COA of Formula: C5H6BrN3

6-Bromopyridine-3,4-diamine (200.0 mg, 1.06 mmol) was added to diethyl oxalate (3.0 mL). The mixture was stirred at 130 C. for 12 hours and then cooled to room temperature. Et2O was added thereto to form a solid. The formed solid was filtered and dried under reduced pressure to obtain brown solid compound of 7-bromopyrido[3,4-b]pyrazine-2,3-diol (195.0 mg, 76%). [1236] 1H-NMR (400 MHz, DMSO-d6); delta: 12.23 (brs, 1H), 12.11 (brs, 1H), 8.09 (s, 1H), 7.05 (s, 1H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1033203-41-6, 6-Bromopyridine-3,4-diamine.

Reference:
Patent; C&C RESEARCH LABORATORIES; Ho, Pil Su; Yoon, Dong Oh; Han, Sun Young; Lee, Won Il; Kim, Jung Sook; Park, Woul Seong; Ahn, Sung Oh; Kim, Hye Jung; US2014/315888; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1033203-41-6 ,Some common heterocyclic compound, 1033203-41-6, molecular formula is C5H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 6-bromopyridine-3,4-diamine (100 mg, 0.53 mmol) and lH-pyrazole-4-carboxylic acid (60 mg, 0.53 mmol) in polyphosphoric acid (1 g) was heated in a sealed vial at 200 C for 18 h. The reaction mixture was diluted with water and made basic by addition of NaOH (50% aq.) and a white precipitate formed. The solid thus formed was collected by filtration and washed with water to afford the title compound (150mg, quant.). LCMS (ESI): [M+H]+ 264.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1033203-41-6, 6-Bromopyridine-3,4-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1033203-41-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1033203-41-6, name is 6-Bromopyridine-3,4-diamine, molecular formula is C5H6BrN3, molecular weight is 188.0252, as common compound, the synthetic route is as follows.

0.85 g (4.5 mmol) of Compound 22-1 and 0.34 g (4 mmol) of Compound 22-2 were added to 15 mL of ethanol solution in an N2 atmosphere and heated to undergo a reaction for 5 hours. After the reaction was completed, a residue obtained therefrom was separated and purified by column chromatography (petroleum ether:ethyl acetate=12:1) to obtain 0.71 g (yield: 75%) of Compound 22-3.

Statistics shows that 1033203-41-6 is playing an increasingly important role. we look forward to future research findings about 6-Bromopyridine-3,4-diamine.

Reference:
Patent; Samsung Display Co., Ltd.; YOO, Byeongwook; KIM, Myeongsuk; YE, Jimyoung; KIM, Hyoyeon; YOON, Jihwan; HWANG, Jaehoon; (72 pag.)US2019/218240; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1033203-41-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1033203-41-6, name is 6-Bromopyridine-3,4-diamine, molecular formula is C5H6BrN3, molecular weight is 188.0252, as common compound, the synthetic route is as follows.

0.85 g (4.5 mmol) of Compound 22-1 and 0.34 g (4 mmol) of Compound 22-2 were added to 15 mL of ethanol solution in an N2 atmosphere and heated to undergo a reaction for 5 hours. After the reaction was completed, a residue obtained therefrom was separated and purified by column chromatography (petroleum ether:ethyl acetate=12:1) to obtain 0.71 g (yield: 75%) of Compound 22-3.

Statistics shows that 1033203-41-6 is playing an increasingly important role. we look forward to future research findings about 6-Bromopyridine-3,4-diamine.

Reference:
Patent; Samsung Display Co., Ltd.; YOO, Byeongwook; KIM, Myeongsuk; YE, Jimyoung; KIM, Hyoyeon; YOON, Jihwan; HWANG, Jaehoon; (72 pag.)US2019/218240; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine, the common compound, a new synthetic route is introduced below. Recommanded Product: 6-Bromopyridine-3,4-diamine

To a stirred solution of 6-bromopyridine-3,4-diamine (1.5 g, 8 mmol) in triethylorthoformate (7.11 g, 48 mmol) was added acetic anhydride (7.35 g, 72 mmol)) and stirred at 90C for 6h. The reaction mixture was cooled and evaporated to dryness, then 10 mL 10N NaOH solution was added and heated the contents at 60 C for 50 min. After reaction mixture was cooled acidified with AcOH to a pH 6, then added crushed ice stirred for 15 minutes precipitated solid was filtered. The precipitated solid was washed with n-pentane to get 6-bromo-3H- imidazo[4,5-c]pyridine (1.5 g, 94%) as pale brown solid. LC-MS (method 32): Rt = 0.26 min; m/z = 198.0 (M+H+).

The synthetic route of 1033203-41-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine, the common compound, a new synthetic route is introduced below. Recommanded Product: 6-Bromopyridine-3,4-diamine

To a stirred solution of 6-bromopyridine-3,4-diamine (1.5 g, 8 mmol) in triethylorthoformate (7.11 g, 48 mmol) was added acetic anhydride (7.35 g, 72 mmol)) and stirred at 90C for 6h. The reaction mixture was cooled and evaporated to dryness, then 10 mL 10N NaOH solution was added and heated the contents at 60 C for 50 min. After reaction mixture was cooled acidified with AcOH to a pH 6, then added crushed ice stirred for 15 minutes precipitated solid was filtered. The precipitated solid was washed with n-pentane to get 6-bromo-3H- imidazo[4,5-c]pyridine (1.5 g, 94%) as pale brown solid. LC-MS (method 32): Rt = 0.26 min; m/z = 198.0 (M+H+).

The synthetic route of 1033203-41-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem