Category: 1033610-45-5

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1033610-45-5, name is 4-Bromo-3,5-dimethoxypyridine, molecular formula is C7H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1033610-45-5

4-bromo-3,5-dimethoxypyridine of structural formula 2 (440 mg, 2.0 mmol, 1.0 equiv.) was dissolved in 2 mL of an acetic acid solution of 33% by mass of hydrogen bromide. Heat to 130 C and react for 24 hours. After the reaction was completed, a 10% aqueous sodium hydrogencarbonate solution was added. After the workup, 335 mg of the crude product was obtained. Since the structural formula 3 is easily decomposed in the air, the crude product was used directly in the next reaction.

With the rapid development of chemical substances, we look forward to future research findings about 1033610-45-5.

Reference:
Patent; Chongqing University; Li Yang; Chen Di; (11 pag.)CN109836446; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1033610-45-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1033610-45-5, name is 4-Bromo-3,5-dimethoxypyridine. A new synthetic method of this compound is introduced below.

To an ice-cooled suspension of sodium hydride (60% dispersion in mineral oil, 650 mg, 16.3 mmol) in dry DMF (10 ml) was added 4-methoxybenzyl alcohol (2.24 g, 16.3 mmol) drop-wise via syringe. Vigorous evolution of hydrogen was observed and the reaction was allowed to warm to room temperature and stirred for 15 minutes. 4-Bromo-3,5-dimethoxypyridine (1.17 g, 5.41 mmol) was added and the reaction heated to 900C overnight. After cooling, only trace starting material could be detected by TLC analysis and the reaction was quenched with water and extracted with EtOAc. The organic layer was washed with water 3 times then brine, dried over MgSO4 and concentrated onto silica-gel under reduced pressure. The solid residue was purified by flash chromatography (silica-gel, eluted sequentially with EtOAc : hexanes, 2:1, 1:0) to give the product as a tan solid (865 mg, 58%). 1H-NMR (300 MHz, CDCl3) delta 7.96 (s, 2H), 7.33 (d, J= 8.5 Hz, 2H), 6.84 (d, J= 8.5 Hz, 2H), 5.11 (s, 2H), 3.89 (s, 6H), 3.78 (s, 3H). MS (ES+) m/z 276.1 (M + H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1033610-45-5, 4-Bromo-3,5-dimethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; BIONOMICS LIMITED; WO2008/70908; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem