Category: 1034467-80-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1034467-80-5, name is 5-Cyclopropyl-2-fluoropyridine. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

A mixture of 5-cyclopropyl-2-fluoropyridine (543 mg, 2.92 mmol), (R)-tert-butyl 3- aminopyrrolidine-l-carboxylate (400 mg, 2.92 mmol) and Cs2C03 (1904 mg, 5.84 mmol) in DMSO (2 mL) was stirred at 160 C for 24 hours. The mixture was cooled to RT diluted with water (20 mL) and extracted with EtOAc (20 mL*3). The combined organic phase was concentrated and the residue was purified by flash chromatography on silica gel (PE/EtOAc = 2/1) to afford (R)-tert- butyl 3-((5-cyclopropylpyridin-2-yl)amino)pyrrolidine-l-carboxylate (35 mg, 4%) as a yellow solid. [M+H] Calc?d for CI7H25N302, 304.1; Found, 304.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1034467-80-5, 5-Cyclopropyl-2-fluoropyridine.

Reference:
Patent; KINNATE BIOPHARMA INC.; KANOUNI, Toufike; ARNOLD, Lee D.; KALDOR, Stephen W.; MURPHY, Eric A.; TYHONAS, John; (0 pag.)WO2020/6497; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1034467-80-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1034467-80-5, name is 5-Cyclopropyl-2-fluoropyridine, molecular formula is C8H8FN, molecular weight is 137.15, as common compound, the synthetic route is as follows.

Preparation 155-Cyclopropyl-2-fluoro-3-iodo-pyridineCool a solution of 5-cyclopropyl-2-fluoro-pyridine (1.3 g, 9.5 mmol) in THF (20 mL) to -75 0C in a dry ice-acetone bath under nitrogen. Add lithium diisopropylamide (2 M in THF, 6 mL, 12 mmol) during a period of 30 min. Stir the mixture for another 3 h before adding iodine (2.9 g, 11.4 mmol, dissolved in 50 mL of THF). Keep stirring for 2 more hours before adding water (100 mL) to the mixture. Then allow to warm to RT during 1 h under stirring. Treat the mixture with a saturated sodium thiosulfate solution (50 mL). Extract the solution with ether. Concentrate the solution in vacuo. Purify by column chromatography (hexane-^ 20% ethyl acetate in hexane) to afford the title compound as a yellow oil (1.7 g, 68 %). 1H NMR (400 MHz- CDCl3) delta 7.99 (d, J= 3 Hz, IH), 7.39 (td, J= 3, 5 Hz, IH), 6.79 (dd, J= 3, 8 Hz, IH), 0.96-1.02 (m, 2H), 0.63-0.69 (m, 2H).

Statistics shows that 1034467-80-5 is playing an increasingly important role. we look forward to future research findings about 5-Cyclopropyl-2-fluoropyridine.

Reference:
Patent; ELI LILLY AND COMPANY; WO2008/144222; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1034467-80-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1034467-80-5, name is 5-Cyclopropyl-2-fluoropyridine, molecular formula is C8H8FN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a reaction vial designed for microwave heating, 3-cyclopropyl-4-phenoxy-l H- pyrazole (0.16 g, 0.799 mmol), 5-cyclopropyl-2-fluoropyridine (intermediate 50) (0.11 g, 0.799 mmol) and cesium carbonate (0.28 g, 0.878 mmol) were heated in dry acetonitrile (4 mL, dried over 4A molecular sieves) at 160 C for one hour. The resulting was adsorbed over silica and purified by chromatography over silica gel (cyclohexane – ethyl acetate 95/5) to yield the expected compound as an oil (0.2 g, 78 %). 5H (CDCI3): 0.72 (m, 2H); 0.85 (m, 2H); 1.03 (m, 4H); 1.93 (m, 2H); 7.09 (m, 3H); 7.31 (m, 2H); 7.40 (dd, 1H, J = 2.4 and 8.5); 7.80 (d, 1 H, J – 8.5); 8.15 (d, 1H, J – 2.4); 8.27 (s, 1H). 13C (CDC13): 7.0; 7.3; 8.7; 12.6; 11 1 .0; 1 16.2; 1 17.6; 122.5; 129.6; 135.4; 136.3 ; 140.1 ; 146.0; 148.5; 149.7; 158.7. HRMS: Calc. for C20H19N3O + H: 318.1606; Found: 318.1562.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1034467-80-5, 5-Cyclopropyl-2-fluoropyridine.

Reference:
Patent; INSTITUT PASTEUR; JANIN, Yves-Louis; GUILLOU, Sandrine; LUCAS-HOURANI, Marianne; MUNIER-LEHMANN, Helene; NOEL, Anne; SALANOUVE, Elise; TANGY, Frederic; VIDALAIN, Pierre-Olivier; WO2015/155680; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem