Category: 103577-66-8

Adding a certain compound to certain chemical reactions, such as: 103577-66-8, (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H10F3NO2, blongs to pyridine-derivatives compound. COA of Formula: C9H10F3NO2

Ph3PO (43.78 g, 157.5 mmol) was dissolved in toluene (100 mL) in a 500 mL three-necked flask and BTC(14.84 g, 50 mmol) was dissolved in toluene (60 mL) and placed in a 150 mL constant pressure dropping funnel,BTC was added dropwise at room temperature, and the temperature was raised to 60 ° C after completion of the dropwise addition.After incubation for 4 hours, 2-hydroxymethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine(33.15 g, 150 mmol) was dissolved in 75 mL of toluene and added at 40 ° C to precipitate a white solid. After the reaction was carried out for 2 hours, the reaction was stopped and the white solid was obtained by filtration to dryness 2-chloromethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine hydrochloride 40.01 g, product yield 97percent

The synthetic route of 103577-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Hainan Weikang Pharmaceutical (Qianshan) Co., Ltd.; Weng Yiyi; Su Weike; Wang Jincan; Wang Ningqing; Zhong Da; Zhu Zhixin; (27 pag.)CN107011252; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103577-66-8, name is (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H10F3NO2

f) 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride 160 ml of toluene were added to 14.9 g (0.067 mole) of 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine in methylene chloride followed by distillation of methylene chloride. The solution was purified with 2.7 g of acivated charcoal, filtered and washed with 36 ml of toluene. To this solution 5.4 ml (0.075 mole) of thionyl chloride in 27 ml of toluene were added dropwise and maintained for 3 hours. The gas was removed under vacuum at room temperature, then the resulting mixture was cooled to a temperature of from 0 to 5°C and stirred for one hour. The product was filtered, washed with 3 ml of toluene and dried in a vacuum dryer at 35-40°C. The yield was 15.65 g (84 percent).

With the rapid development of chemical substances, we look forward to future research findings about 103577-66-8.

Reference:
Patent; Krka Tovarna Zdravil, D.D., Novo Mesto; EP1681056; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem