Category: 10366-35-5

Reference of 10366-35-5 ,Some common heterocyclic compound, 10366-35-5, molecular formula is C6H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 3 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinamide Operation was carried out in a manner similar to the one described in Example 2, using 1.6 g of 2-chloronicotinamide, 3.2 g of 1-(2,3-dihydroxypropyl)piperazine and 30 ml ethanol and refluxing overnight. Column purification of the residue gave 1 g of 2-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinamide, which, recrystallized from acetone, melted at 140-142C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10366-35-5, 2-Chloronicotinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOMPE’ FARMACEUTICI S.p.A.; EP230402; (1993); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 10366-35-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10366-35-5, name is 2-Chloronicotinamide, molecular formula is C6H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A microwave reaction tube was charged with an amide (1 equiv.), PdCl2(MeCN)2 (5 mol%) and BINAP (5 mol%), The tube was evacuated and backfilled with argon (3 times), and then dry DMF (4 mL/1 mmol of starting material), phenylacetylene (1.5 equiv.), and DBU (2 equiv.) were added. The mixture was sparged with argon for 5 min and then irradiated under microwaves at 120 C for 30 minutes. After cooling to room temperature, the solvent was partially removed in vacuo, then the mixture was diluted in EtOAc (10 mL), washed with water (5 mL) and brine (5 mL). The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated. The crude product was purified by chromatography on silica gel to give the desired product.

According to the analysis of related databases, 10366-35-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hellal, Malik; Cuny, Gregory D.; Tetrahedron Letters; vol. 52; 42; (2011); p. 5508 – 5511;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 10366-35-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10366-35-5, name is 2-Chloronicotinamide, molecular formula is C6H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To an aqueous solution of Na2Se2 (prepared from selenium metal (1.00 g, 12.66 mmol) and NaBH4 (434 mg, 11.47 mmol) in 60 ml distilled water) was added a solution of 2-chloro-3-nicotinamide (2.00 g, 12.77 mmol) with stirring under a nitrogen atmosphere. The reaction mixture was refluxed for 2 h with stirring. After cooling to room temperature, product was extracted with a chloroform-methanol (3:1 ratio) mixture. The organic phase was separated, washed with sodium bicarbonate solution followed by water, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under vacuum and the residue was column chromatographed with chloroform-methanol (90:10) mixture. The solution on evaporation afforded yellow powder (yield 216 mg, 8%; due to degradation during column purification product yield was significantly reduced), m.p. 126-128 C. Anal. for C12H10N4O2Se2; Calcd: C, 36.02; H, 2.52; N, 14.00%. Found C, 34.64; H, 2.73; N, 13.47%. UV-vis (in MeOH) (lambdamax in nm): 326, 402. IR in KBr (upsilon cm-1): 3250 (NH2), 1671 (CO). 1H NMR (dmso-d6) delta: 7.28 (d, d, 6 Hz, CH-5, py); 8.35, 7.84 (NH2); 8.16 (d, 7.5 Hz, py); 8.49 (d, 5 Hz, py); 13C{1H} NMR (dmso-d6) delta: 119.7, 128.1 (C-Se),135.5, 151.5, 160.5 (C-3, py); 168.2 (CO). 77Se{1H} NMR (dmso-d6) delta: 525 ppm. Mass (m/z): 400 (M+).

According to the analysis of related databases, 10366-35-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Parashiva Prabhu; Phadnis, Prasad P.; Wadawale, Amey P.; Indira Priyadarsini; Jain, Vimal K.; Journal of Organometallic Chemistry; vol. 713; (2012); p. 42 – 50;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 10366-35-5, 2-Chloronicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H5ClN2O, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5ClN2O

General procedure: To a solution of the corresponding amide (2 mmol) in THF (10 mL) was added chlorocarbonylsulfenyl chloride (350 muL, 4 mmol). The mixture was stirred at ambient temperature for 16 h. The solvent was removed in vacuo and the crude products were puried by silica-gel column chromatography using ethyl acetate/hexane as eluent solvent system.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10366-35-5, 2-Chloronicotinamide, and friends who are interested can also refer to it.

Reference:
Article; Yang, Jianzhong; Pi, Weiyi; Xiong, Li; Ang, Wei; Yang, Tao; He, Jun; Liu, Yuanyuan; Chang, Ying; Ye, Weiwei; Wang, Zhenling; Luo, Youfu; Wei, Yuquan; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1424 – 1427;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem