Synthetic Route of 1037223-35-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1037223-35-0, name is 2-Bromo-6-isopropylpyridine, molecular formula is C8H10BrN, molecular weight is 200.08, as common compound, the synthetic route is as follows.
Compd. 1B (5. 0g, 9. 50mmol), 2-bromo-6-Isopropylcyclohexanecarboxylic polypyridine (3. 0g, 19. 0mmol), sodium carbonate (7. 5g, 19. 0mmol) of dimethyl ether (100 ml)/ water solution (20 ml), tetrakis (triphenylphosphine) palladium (1. 0g, 0. 95mmol) in addition to 10 C, reflux in 12 hours. Ice water (100 ml) is added, the extracted with ethyl acetate (100 ml × 3 times) the reaction liquid. After cleaning the saturated solution, dried with sodium sulfate, filtration, concentrating, column chromatography (ethyl acetate/aminopentanenitrile = 10/1) by purification, yellow oilies compd. 2A is obtained. Yield 4. 0g yield at 83%.
Statistics shows that 1037223-35-0 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-6-isopropylpyridine.
Reference:
Patent; JAPAN POLYPROPYLENE CORP; JAPAN POLYETHYLENE CORP; KOBAYASHI, MINORU; UCHINO, HIDEFUMI; (40 pag.)JP2015/155397; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem