Synthetic Route of 104408-23-3 ,Some common heterocyclic compound, 104408-23-3, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
STR93 (Process (a) 16.9 g (0.1 mole) of ethyl ethoxymethylenecyanoacetate and 17.8 g (0.1 mole) of 3,5-dichloro-pyrid-2-ylhydrazine in 150 ml of ethoxyethanol are stirred at 80 C. for 5 hours and then at 120 C. for a further 2 hours. For working up, the solvent is removed in vacuo. 29.6 g (98% of theory) of 5-amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole of melting point 98-101 C. are obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,104408-23-3, its application will become more common.
Reference:
Patent; Bayer Aktiengesellschaft; US4772312; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem