Category: 1049744-89-9

Electric Literature of 1049744-89-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1049744-89-9, name is 2-Hydrazino-5-(trifluoromethyl)pyridine, HCl. A new synthetic method of this compound is introduced below.

(2) Subsequently, Journal of Chemical Society Perkin Trans I (J. Chem. Soc. Perkin trans. I), p. 1875 (in 1988), it gave way to Ethoxy methylene ethyl acetoacetate (6.1g) and the above-described 5- (2-trifluoromethyl synthesized as described in the methyl) pyridin-2-yl hydrazine hydrochloride (7.0g ) water (40), ethanol (40) was added to a solvent mixture, and addition of sodium hydroxide (2.6g), the reaction mixture was stirred for 3 hours at reflux temperature and further stirred for one hour. The reaction solution was treated with a 1N aqueous hydrochloric acid solution, and by purifying the precipitated solid with ethyl acetate-hexane mixed solvent -n- 5-methyl-1- [5- (trifluoromethyl) pyridin-2-yl] -1H- pyrazol to give the 4-carboxylic acid (6.5g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1049744-89-9, its application will become more common.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015/2661; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1049744-89-9, name is 2-Hydrazino-5-(trifluoromethyl)pyridine, HCl, molecular formula is C6H7ClF3N3, molecular weight is 213.59, as common compound, the synthetic route is as follows.Computed Properties of C6H7ClF3N3

A solution of 2-chloro-6- [3 -(diethoxymethyl)- 1,2,4-oxadiazol-5-yl]pyridine (750 mg, 2.58 mmol) in MeCN(10 mL) was treated with 10% HC1 (3 mL, 9 mmol) andstirred at 85 C for 3 h. The resulting solution was thencooled to RT and treated with 2-hydrazino-5-(trifluoromethyl)pyridine hydrochloride (943 mg, 2.71 mmol). After stirring for 1.5 h at RT the finesuspension was diluted with water (15 mL) and filtered. The filtercake was washed with water (10 mL) and dried at room temperature to give the title compound as a brown solid (790 mg, 92% purity, 1.97 mmol, 76%, >95:5 mixture of stereoisomers).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1049744-89-9, 2-Hydrazino-5-(trifluoromethyl)pyridine, HCl, and friends who are interested can also refer to it.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; KENNEDY, Jason W. J.; VON MORGENSTERN, Sascha; (37 pag.)WO2016/135062; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1049744-89-9 ,Some common heterocyclic compound, 1049744-89-9, molecular formula is C6H7ClF3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 5-(4-methoxyphenyl)-1,2,4-oxadiazole-3-carbaldehyde (500 mg, 2.40 mmol) and2-hydrazino-5-(trifluoromethyl)pyridine hydrochloride(877 mg, 2.52 mmol) in MeCN (10 n) was stirred atRT for 3 h. The resulting suspension was diluted with water (10 mL) and filtered. The filter cake was washed with water (10 mL) and dried overnight invacuum oven (50 C, 20 mbar) to give the title compound as a brown solid (630 mg, 1.73 mmol, 72%,Ca. 90:10 mixture of stereoisomers).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1049744-89-9, its application will become more common.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; KENNEDY, Jason W. J.; VON MORGENSTERN, Sascha; (37 pag.)WO2016/135062; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem