Category: 105250-16-6

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105250-16-6, name is (2-Methylpyridin-4-yl)methanol, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.category: pyridine-derivatives

Example S4: Preparation of 4- (2-Methyl-pyridin-4-yl)-2H-pyrazol-3-ylamine; a) To a stirred mixture of 4-hydroxymethyl-2-methyl-pyridine [CAS No. 105250-16-6] (3.37 g, 27.4 mmol), potassium cyanide (3.56 g, 54.7 mmol) and 18-crown-6 (0.72 g, 2.74 mmol) in acetonitrile (75 ml) was added dropwise at 15-20C a solution of tributylphosphine (7.16 g, 30.1 mmol) in acetonitrile (25 ml). The reaction mixture was stirred at room temperature for 25 h, poured into water (100 ml) and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were washed with water (3 x 100 ml), brine (100 ml) dried (MgSO4) and evaporated. The crude product was further purified by column chromatography on silica gel (ethyl acetate) to yield 4-cyanomethyl- 2-methyl-pyridine (2.26 g, 62%) as a brown oil

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105250-16-6, (2-Methylpyridin-4-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-ROCHE AG; WO2005/40171; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 105250-16-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105250-16-6, name is (2-Methylpyridin-4-yl)methanol, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.

To a stirred, ice-cooled solution of compound 66 (3.68 g, 16.4 mmol), prepared as described in US 6,720,328, in CH2CI2 (50 ml) was added ice-cold TFA (6.07 ml, 9.38 g, 82.1 mmol) via syringe over a period of ~1 min. The resultant clear yellow solution was stirred at 0 0C for 10 min, then at RT for 25h. Volatiles were removed under reduced pressure, and the residue was redissolved in CH2CI2 (35 ml). To this solution was added portionwise (exothermic) 7N methanolic ammonia (5 ml, 35 mmol), making the solution basic to pH paper and resulting in the formation of a precipitate. Solvent was removed under reduced pressure, and the residue was triturated with EtOAc (30 ml). The mixture was filtered, the filtrate was stripped of solvent under reduced pressure, and the residue was purified via flash chromatography on silica gel, eluting with CH2CI2-MeOH -NH3 (90:9:0.25), to obtain compound 67 as an off-white powder (1.43 g; 70percent).

The chemical industry reduces the impact on the environment during synthesis 105250-16-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SCHERING CORPORATION; WO2007/1975; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem