Category: 105252-99-1

Electric Literature of 105252-99-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105252-99-1, name is 4-Amino-6-fluoropyridin-2(1H)-one, molecular formula is C5H5FN2O, molecular weight is 128.1, as common compound, the synthetic route is as follows.

Step a: To a 0 C solution of 4-amino-6-fluoropyridin-2(1H)-one (490 mg, 3.83 mmol) in AcOH (19 mL) was added NIS (818 mg, 3.63 mmol). The reaction mixture solidated, was allowed to warm to RT, and stirred for 1 h. The volatiles were removed under reduced pressure. The residue was transferred to a separation funnel containing sat. aq. Na25203 (15 mL), sat. aq. NH4C1 (15 mL), and water (15 mL). The mixture was extracted with Et20 (4 x 50 mL) and the combined organic extracts were dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 5% gradient of MeOH/DCM) to give 4-amino-6-fluoro-3-iodopyridin-2(1H)-one (54 mg, 0.2 13 mmol) as a white solid. MS m/z 255.0 (M+H).

The chemical industry reduces the impact on the environment during synthesis 105252-99-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 105252-99-1, Adding some certain compound to certain chemical reactions, such as: 105252-99-1, name is 4-Amino-6-fluoropyridin-2(1H)-one,molecular formula is C5H5FN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 105252-99-1.

Step a: A suspension of 4-ammno-6-fluoropyridin-2(1H)-one (570 mg, 4.45 mmol), K2C03 (922 mg, 6.67 mmol), and Mel (278 jiL, 4.45 mmol) in EtOH (15 mL) was stirred for 15 h at 70 C. After cooling to RT, the reaction mixture was filtered and rinsed with EtOH. The filtrate was suspended in water (40 mL) and extracted with EtOAc (2 x 40 mL) and trifluoroethanol (10% in DCM, 8 x 40 mL). The combined organic extracts were dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 10% gradient of MeOH/DCM) to give 4-amino-6-fluoro- 1-methylpyridin-2(1H)-one (356 mg, 2.51 mmol) as a white solid. MS m/z 142.8 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105252-99-1, 4-Amino-6-fluoropyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 105252-99-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105252-99-1, name is 4-Amino-6-fluoropyridin-2(1H)-one, molecular formula is C5H5FN2O, molecular weight is 128.1, as common compound, the synthetic route is as follows.

Step a: To a 0 C solution of 4-amino-6-fluoropyridin-2(1H)-one (490 mg, 3.83 mmol) in AcOH (19 mL) was added NIS (818 mg, 3.63 mmol). The reaction mixture solidated, was allowed to warm to RT, and stirred for 1 h. The volatiles were removed under reduced pressure. The residue was transferred to a separation funnel containing sat. aq. Na25203 (15 mL), sat. aq. NH4C1 (15 mL), and water (15 mL). The mixture was extracted with Et20 (4 x 50 mL) and the combined organic extracts were dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 5% gradient of MeOH/DCM) to give 4-amino-6-fluoro-3-iodopyridin-2(1H)-one (54 mg, 0.2 13 mmol) as a white solid. MS m/z 255.0 (M+H).

The chemical industry reduces the impact on the environment during synthesis 105252-99-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 105252-99-1, Adding some certain compound to certain chemical reactions, such as: 105252-99-1, name is 4-Amino-6-fluoropyridin-2(1H)-one,molecular formula is C5H5FN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 105252-99-1.

Step a: A suspension of 4-ammno-6-fluoropyridin-2(1H)-one (570 mg, 4.45 mmol), K2C03 (922 mg, 6.67 mmol), and Mel (278 jiL, 4.45 mmol) in EtOH (15 mL) was stirred for 15 h at 70 C. After cooling to RT, the reaction mixture was filtered and rinsed with EtOH. The filtrate was suspended in water (40 mL) and extracted with EtOAc (2 x 40 mL) and trifluoroethanol (10% in DCM, 8 x 40 mL). The combined organic extracts were dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 10% gradient of MeOH/DCM) to give 4-amino-6-fluoro- 1-methylpyridin-2(1H)-one (356 mg, 2.51 mmol) as a white solid. MS m/z 142.8 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105252-99-1, 4-Amino-6-fluoropyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem