The important role of 3-Bromo-6-chloropicolinonitrile

The chemical industry reduces the impact on the environment during synthesis 1053659-39-4, I believe this compound will play a more active role in future production and life.

Synthetic Route of 1053659-39-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1053659-39-4, name is 3-Bromo-6-chloropicolinonitrile, molecular formula is C6H2BrClN2, molecular weight is 217.4505, as common compound, the synthetic route is as follows.

In a dry 100 ml three-necked flask, 5 g of 3-bromo-6-chloro-pyridine-2-cyanide and 50 ml of 90 wt% sulfuric acid were added, and the temperature was raised to 170 C with stirring, the reaction was carried out for 3.0 h, and the reaction solution was poured into 150 ml of ice water. The solid precipitated under stirring, filtered with suction, washed with a small amount of water, and dried to obtain 3-bromo-6-chloro-pyridine-2carboxylic acid. Yield: 89%

The chemical industry reduces the impact on the environment during synthesis 1053659-39-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hebei University; Li Wan; Feng Ke; Li Meilin; Zhang Yi; Jiang Ruonan; Yang Kaiyue; Zhu Huajie; (4 pag.)CN110432274; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem