Category: 10592-27-5

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10592-27-5, name is 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H8N2, molecular weight is 120.15, as common compound, the synthetic route is as follows.Recommanded Product: 10592-27-5

Step 2; A solution of Br2 (2.78 ml, 8.64 g, 54 mmole) in dry dichloromethane (40 ml) was added dropwise over a period of 1 h 45 min to a stirred and cooled (-10C) solution of 2.3-dihydro-1H-pyrrolo[2,3-b]pyridine (6.5 g,54 mmole) in a mixture of dry dichloromethane (60 ml) and pyridine (6 ml). The suspension was stirred at 0C for 2 hrs, poured into a mixture of NaHCO3 (120 ml) and saturated aqueous Na2S2O3 (15 ml) and extracted with a solution of ethyl acetate/methanol (3X200 ml). The organic layers were concentrated to afford 3.7 g of 5-bromo- 2,3-dihydro- 1H-pyrrolo[2,3-b]pyridine (2) after purification by flash chromatography using dichloromethane as eluent (35% yield). 1H NMR (400 MHz, DMSO-D6) delta ppm 2.98 ( t, J = 8.54 Hz, 2H ) 3.48 (t, J=8.55 Hz, 2H) 6.58 (bs, 1 H) 7.37(s,1 H) 7.71 (s,1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10592-27-5, 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; EP2070928; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10592-27-5, name is 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. name: 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine

l,3-Dibromo-5,5-dimethylhydantoin (9.64 g) was added to a mixture of 2,3-dihydro- lH-pyrrolo[2,3-6]pyridine (8.1 g), 4-toluenesulphonic acid monohydrate (1.03 g) and methylene chloride (550 ml) and the resultant mixture was stirred at ambient temperature for 1 hour. The reaction solution was decanted from a black tar. The organic solution was washed with an 0.2M aqueous sodium thiosulphate solution (2 x 250 ml) and with brine, dried over magnesium sulphate and evaporated. There was thus obtained 5-bromo-2,3-dihydro- lH-pyrrolo[2,3-6]pyridine (4.05 g); 1H NMR Spectrum: (DMSOd6) 2.99 (t, 2H), 3.47-3.52 (m, 2H), 6.58 (s, IH), 7.38-7.39 (m, IH), 7.72 (t, IH). Mass Spectrum; M+H+ 199 and 201.

The synthetic route of 10592-27-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/135398; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem