Category: 106047-17-0

Application of 106047-17-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 106047-17-0 as follows.

REFERENTIAL EXAMPLE 239 4-[4-(Methoxycarbonyl)phenyl]pyridine N-oxide: The compound (1.49 g) obtained in Referential Example 238 was dissolved in methylene chloride (30 ml), 70% m-chloroperbenzoic acid (3.46 g) was added, and the mixture was stirred at room temperature for 1 hour. An aqueous solution of sodium sulfite was added to conduct liquid separation. The resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain the title compound (1.33 g). 1H-NMR (DMSO) delta: 3.88(3H,s), 7.86(2H,d,J=7.2 Hz), 7.94(2H,d,J=8.3 Hz), 8.05(2H,d,J=8.3 Hz), 8.30(2H,d,J=7.2 Hz). MS (FAB) m/z: 230(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106047-17-0, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; US2005/20645; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 106047-17-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106047-17-0, name is Methyl 4-(pyridin-4-yl)benzoate, molecular formula is C13H11NO2, molecular weight is 213.23, as common compound, the synthetic route is as follows.

Reference Example 18 Methyl 4-[pyridine-N-oxide-4-yl]-benzoate. To a cooled (0 C.) solution of methyl 4-[pyridin-4-yl]-benzoate (2.1 g, 10 mmol) (reference example 19a) in CH2Cl2 (41 mL) is added m-CPBA (3.4 g, 50-60% technical grade, 10 mmol). The resulting solution is stirred for 1 hour then a further portion of m-CPBA added (1.7 g, 5 mmol). This solution is stirred for 1 hour (temperature held between 5-10 C.) then the reaction mixture poured directly onto a silica gel column. Elution with 10% MeOH/40% EtOAc/50% CH2Cl2 gave 2.0 g of the title compound as a tan solid. 1H NMR (CDC3OD) d 3.94 (s, 3H), 7.90 (m, 4H), 8.14 (d, J=8.5 Hz, 2H), 8.39 (d, J=7 Hz, 2H). MS (EI) m/z 230 (M)+.

Statistics shows that 106047-17-0 is playing an increasingly important role. we look forward to future research findings about Methyl 4-(pyridin-4-yl)benzoate.

Reference:
Patent; Aventis Pharmaceuticals Inc.; US6541505; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem