Category: 1060805-03-9

New learning discoveries about Synthetic Route of 1060805-03-9

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060805-03-9, 3-Fluoro-4-methoxypyridine.

Synthetic Route of 1060805-03-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060805-03-9, name is 3-Fluoro-4-methoxypyridine, molecular formula is C6H6FNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 3-fluoro-4-methoxypyridine (2 mmol) in THF (10ml) was cooled to-780C. To this solution was added a solution of lithium diisopropylamide (LDA; 4.2 mmol) in hexane slowly at same temperature. After 2Oh at -780C, to the mixture was added trimethoxyborane (0.48ml) and stirred for 2h, followed by an addition of peracetic acid (0.72 ml; 32% in dilute acetic acid). The mixture was allowed to warm to O0C under stirring for Ih, then cooled to -2O0C, sodium dithionite (0.8g in 2ml water) was added dropwise. The mixture was extracted with DCM and the extract was dried and concentrated. The residue was purified by chromatography, eluting with 1:8 MeOH:DCM to give the expected product as a white solid (52%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060805-03-9, 3-Fluoro-4-methoxypyridine.

Reference:
Patent; BTG INTERNATIONAL LIMITED; WO2009/103950; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem