Category: 1060805-95-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1060805-95-9, name is 4-Chloro-6-methylnicotinic acid, the common compound, a new synthetic route is introduced below. Formula: C7H6ClNO2

To a solution of 4-chloro-6-methylnicotinic acid(0.1 g, 0.58 mmol) in ethanol (10.0 mL) was added SOCl2 (0.25 mL,3.49 mmol) at 0 C and the reaction mixture was stirred at 85 C for 12 h. Thereaction mixture was concentrated and the crude product was dissolved in EtOAc,washed with water, brine, dried over anhydrous Na2SO4,filtered and concentrated. The crude residue was purified by Combiflashpurifier with 5% MeOH in DCM to afford the title compound as off-white solid(0.1 g, 82 %). 1H NMR (DMSO-d6,400 MHz) delta 1.26 (t, J = 6.8 Hz, 3H), 1.32 (t, J = 7.2 Hz, 3H), 2.44 (s, 3H), 4.12-4.17(m, 2H), 4.20-4.26 (m, 2H), 7.03 (s, 1H), 8.56 (s, 1H); MS (ESI) m/z 210.1 (M+H)+.

The synthetic route of 1060805-95-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ruf, Sven; Hallur, Mahanandeesha Siddappa; Anchan, Nisha K.; Swamy, Indu N.; Murugesan, Karthikai Raj; Sarkar, Sayantani; Narasimhulu, Lokesh Kananti; Putta, V.P. Rama Kishore; Shaik, Shama; Chandrasekar, Devaraj Venkatapura; Mane, Vishal Subhash; Kadnur, Sanjay Venkatachalapathi; Suresh, Juluri; Bhamidipati, Ravi Kanth; Singh, Manvi; Burri, Raghunadha Reddy; Kristam, Rajendra; Schreuder, Herman; Czech, Joerg; Rudolph, Christine; Marker, Alexander; Langer, Thomas; Mullangi, Ramesh; Yura, Takeshi; Gosu, Ramachandraiah; Kannt, Aimo; Dhakshinamoorthy, Saravanakumar; Rajagopal, Sridharan; Bioorganic and Medicinal Chemistry Letters; vol. 28; 5; (2018); p. 922 – 925;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1060805-95-9, name is 4-Chloro-6-methylnicotinic acid, the common compound, a new synthetic route is introduced below. Formula: C7H6ClNO2

To a solution of 4-chloro-6-methylnicotinic acid(0.1 g, 0.58 mmol) in ethanol (10.0 mL) was added SOCl2 (0.25 mL,3.49 mmol) at 0 C and the reaction mixture was stirred at 85 C for 12 h. Thereaction mixture was concentrated and the crude product was dissolved in EtOAc,washed with water, brine, dried over anhydrous Na2SO4,filtered and concentrated. The crude residue was purified by Combiflashpurifier with 5% MeOH in DCM to afford the title compound as off-white solid(0.1 g, 82 %). 1H NMR (DMSO-d6,400 MHz) delta 1.26 (t, J = 6.8 Hz, 3H), 1.32 (t, J = 7.2 Hz, 3H), 2.44 (s, 3H), 4.12-4.17(m, 2H), 4.20-4.26 (m, 2H), 7.03 (s, 1H), 8.56 (s, 1H); MS (ESI) m/z 210.1 (M+H)+.

The synthetic route of 1060805-95-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ruf, Sven; Hallur, Mahanandeesha Siddappa; Anchan, Nisha K.; Swamy, Indu N.; Murugesan, Karthikai Raj; Sarkar, Sayantani; Narasimhulu, Lokesh Kananti; Putta, V.P. Rama Kishore; Shaik, Shama; Chandrasekar, Devaraj Venkatapura; Mane, Vishal Subhash; Kadnur, Sanjay Venkatachalapathi; Suresh, Juluri; Bhamidipati, Ravi Kanth; Singh, Manvi; Burri, Raghunadha Reddy; Kristam, Rajendra; Schreuder, Herman; Czech, Joerg; Rudolph, Christine; Marker, Alexander; Langer, Thomas; Mullangi, Ramesh; Yura, Takeshi; Gosu, Ramachandraiah; Kannt, Aimo; Dhakshinamoorthy, Saravanakumar; Rajagopal, Sridharan; Bioorganic and Medicinal Chemistry Letters; vol. 28; 5; (2018); p. 922 – 925;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1060805-95-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060805-95-9, name is 4-Chloro-6-methylnicotinic acid, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: A mixture of 4-chloro-6-methyl-3-pyridinecarboxylic acid (10 g, 58.4mmol) and KMnO4 (27.7 g, 175.4 mmol) in H2O was reflux with stirring for 24 h. The mixture was cooled to temperature and filtrated. EtOH was added to the filtrate and filtrated again. The filtrate was concentrated by vacuo to give the crude product 17 g which was used directly to the next reaction without further purification.

According to the analysis of related databases, 1060805-95-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE LLC; WANG, Yonghui; YU, Hongyi; WO2010/59552; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem